Published: 25 June 2025
Author(s): Henrik Falhammar, Mikael Andersson Franko, Jonatan D. Lindh, Jakob Skov, Buster Mannheimer
Issue: July 2025
Section: Original Article

Hyponatremia, defined as a serum sodium concentration <135 mmol/L, is the most common electrolyte imbalance, seen in 15–20 % of all acute hospital admissions [1]. Women, elderly, and individuals with comorbidities are at the highest risk. Symptoms and complications of hyponatremia can be severe, including seizures, coma, and death (due to cerebral edema), but it more commonly presents with mild, nonspecific symptoms such as lethargy, falls, unsteadiness and confusion [2–5]. Newly prescribed medications are a common cause of hyponatremia including, but not limited, to thiazide diuretics, antidepressants and antiepileptics [6–10].

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