Published: 21 June 2025
Author(s): Rui Zhu, Yaoyao Wang, Lili Liu, Xuejiao Liu, Zhanyuan Chen, Yu Wei, Weifeng Lin, Lihua Zhang, Guangda He, Jianfang Cai
Issue: July 2025
Section: Original Article

Heart failure (HF), as the final phase of various cardiovascular disorders, imposes a formidable global healthcare challenge due to its diverse morbidity and high rate of mortality [1]. HF and kidney disease are closely bidirectionally related and frequently coexist [2]. Approximately 50 % of individuals with HF present with concurrent chronic kidney disease (CKD), irrespective of the levels of ejection fraction [3]. Conversely, a substantial proportion of CKD patients, ranging from 17 % to 21 %, will eventually develop HF[4].

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