International Scientific Societies (European Society of Cardiology, American Heart Association, American College of Chest Physician) recommend stratification for the risk of short-term death to drive acute clinical care in patients with acute pulmonary embolism (PE) [1–3]. However, no consensus exists on the optimal strategy for risk stratification beyond the classification in hemodynamically stable and unstable patients. The European Society of Cardiology (ESC) proposed a comprehensive strategy for risk stratification that includes both clinical and instrumental criteria [1].