A 42-year-old female patient presented to the Emergency Department (ED) for unilateral edema involving the entire left lower limb that had been rapidly progressing in the last 24 h. It was associated with blueish skin discolouration and moderate pain (Fig. 1A). The rest of the clinical examination was normal. Regarding medical history, the patient was previously healthy, used oral oestroprogestative contraception, and was an active smoker. In the ED, laboratory findings revealed an hyperleukocytosis of 15.38 G/L and an elevated C-Reactive Protein (CRP) leveling at 134.2 mg/L.
