Published: 31 May 2025
Author(s): Marco Vincenzo Lenti, Giovanni Santacroce, Antonio Di Sabatino
Issue: June 2025
Section: Commentary

Coeliac disease (CD) is a common, lifelong, immune-mediated condition characterised by villous atrophy resulting from the ingestion of dietary gluten [1], which leads to malabsorption and various clinical consequences [2,3]. Particularly in a primary care setting [3], early recognition of CD is crucial. In fact, undiagnosed -and therefore untreated- CD can lead to adverse outcomes [4], such as anaemia, osteoporosis, and, possibly, the development of refractory CD or certain types of cancer. Therefore, early diagnosis and treatment with a gluten-free diet are essential to prevent these complications.

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