Published: 14 June 2025
Author(s): Roser Solans-Laqué, Begoña de Escalante-Yanguela, Eva Fonseca, Guadalupe Fraile, Ferran Martínez-Valle, Luis Caminal, Manuel Monteagudo, Mercedes Pérez-Conesa, Borja Gracia-Tello, Monica Abdilla, Sergio Prieto-González, Aleida Martínez-Zapico, Borja de Miguel-Campo, Jaume Mestre-Torres, REVAS-Registry, from the Systemic Autoimmune Diseases Study Group (GEAS) of the Spanish Society of Internal Medicine (SEMI)
Issue: June 2025
Section: Original Article

Giant cell arteritis (GCA) is the most common systemic vasculitis affecting older people in Western countries, being more prevalent in females [1–4]. Vascular inflammation predominantly affects the aorta and its main branches (especially carotid, vertebral, and temporal arteries), leading to vascular stenosis, occlusions, and aneurysms. Patients typically complain of recent-onset headache, and blood tests show raised biological inflammatory markers [1–4]. However, GCA may present with highly variable symptoms and three overlapping phenotypes have been described: the cranial phenotype, the systemic phenotype, and the isolated polymyalgia rheumatica phenotype [5].

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