Shock is the final common pathway before death and a constant focus of ICU physicians due to its high morbidity and mortality [1] (ranging from 27 % to 60 %) in critically ill patients. Recent studies [2] have shown that inciting illness event induces an unregulated host response, which aggravates microcirculatory injury and therefore shock, prolongs the course of illness, and has an adverse effect on prognosis. Inciting illness event [3] and unregulated host response [4,5] has been emphasized in various syndromes including shock.
