March 2025

Clinical Insights

Aspirin-free strategies after percutaneous coronary intervention: Old habits, consolidated evidence and future perspectives

18 January 2025
Author(s): Antonio Landi, Stefano De Servi, Leonardo De Luca

Antithrombotic therapy represents the mainstay of the pharmacological treatment in patients with coronary artery disease undergoing percutaneous coronary intervention (PCI) [1]. Dual antiplatelet... more

Redefining giant cell arteritis: From current practices to future paradigms

9 December 2024
Author(s): Alessandro Tomelleri, Nicola Farina, Lorenzo Dagna

The management of patients with giant cell arteritis (GCA), the most common vasculitis in adults, has undergone significant transformation over the past decade [1]. This shift has been primarily... more

Commentary

Sodium bicarbonate in metabolic acidosis: A never-ending story?

24 December 2024
Author(s): Giovanna Guiotto

Is it useful to treat metabolic acidosis with bicarbonate or not? This question is still one of the hot topics that doctors deal with in their daily clinical practice, mainly due to the lack of clear... more

Pulmonary metastases and bleeding in the anticoagulated oncology patient with thrombosis: is the risk solely influenced by the location of distant disease?

20 December 2024
Author(s): Manuel Sánchez Cánovas, Javier López Robles

The article by García-García V et al. [1], published in this issue of the European Journal of Internal Medicine,provides a valuable exploration of hemorrhagic complications in cancer-associated... more

Primordial prevention of hypertension

8 December 2024
Author(s): Claudio Ferri

Periculum in mora

Internal Medicine Flashcard

An uncommon and unexpected cause of chest pain: When stockings become trauma

9 January 2025
Author(s): Janneke JC Bastings, Renée Brüggemann, Bart Spaetgens

An 80-year-old woman presented to the emergency department (ED) with acute sternal pain that began after removing her compression stockings. Three days earlier, she experienced a similar episode... more

Female patient with telangiectasia, epistaxis and pulmonary arteriovenous malformation

9 December 2024
Author(s): Fırat Akagunduz, Feride Yagmur Akagunduz, Fergun Yılmaz, Haner Direskeneli

A 55-years-old female patient was admitted to our clinic with a long-standing complaint of epistaxis. She had no medical history and was not taking any medications. Both her children had nosebleeds.... more

Generalized bullous fixed drug eruption

3 December 2024
Author(s): Li Chen, Junfeng Zhou, Lei Yao

A 73-year-old female presented with a diffuse rash accompanied by itching for 3 days. She had taken levofloxacin orally for a cough one day before the rash developed. She had a 16-year history of... more

Esophagitis in an immunocompetent patient: A diagnostic challenge

3 December 2024
Author(s): Shiori Kitaya, Takahiro Yoshinobu, Hajime Kanamori

A 65-year-old man with Parkinson's disease was admitted to hospital for continuous subcutaneous infusion of levodopa/carbidopa. On day 6 of hospitalization, he developed pharyngalgia, sensation of... more

Man with red eyes

1 December 2024
Author(s): Naoya Ishibashi, Tomotaka Takanosu

A 71-year-old male presented to our hospital with vertigo. The supine roll test induced vertigo, leading to a diagnosis of left horizontal semicircular canal benign paroxysmal positional vertigo (... more

Invited Review Article

Treat the patient, not the disease: The embolic stroke of undetermined source as an opportunity to optimize cardiovascular prevention in a holistic approach

23 October 2024
Author(s): George Ntaios, Mayank Dalakoti

“It is much more important to know what sort of patient has a disease than what sort of disease a patient has.”“The good physician treats the disease; the great physician treats the patient who has... more

Letter to the Editor

Disease activity and disability influence CV risk estimation and management of rheumatoid arthritis patients

30 January 2025
Author(s): Elena Bartoloni, Fabio Cacciapaglia, Gian Luca Erre, Elisa Gremese, Andreina Manfredi, Matteo Piga, Garifallia Sakellariou, Francesca Romana Spinelli, Ombretta Viapiana, Fabiola Atzeni, Cardiovascular Obesity and Rheumatic DISeases (CORDIS) Study Group of the Italian Society for Rheumatology (SIR)

We sincerely appreciate Shoulin Dou et al.'s interest in our article, and we are grateful for their constructive comments, which have certainly contributed to raising awareness of the significant... more

Extra-articular manifestations in rheumatoid arthritis: Incidence and predisposing factors. Author's reply

28 January 2025
Author(s): Lotta Ljung, Solbritt Rantapää-Dahlqvist

We appreciate that Wang, Wu and Li [1] have taken an interest in our publication on patients with early rheumatoid arthritis (RA) developing extra articular (ExRA) disease [2]. ExRA manifestations... more

Optimal BMI cutoff for lean MASLD/MetALD and adverse hepatic outcomes in East-Asian populations

13 January 2025
Author(s): Byungyoon Yun, Juyeon Oh, Heejoo Park, Beom Kyung Kim, Jin-Ha Yoon

Nonalcoholic fatty liver disease (NAFLD) is a primary contributor to hepatocellular carcinoma (HCC)/liver cirrhosis (LC), affecting ∼30 % of the global population. Its incidence is rising parallel to... more

Internists at the frontline of epidemic viral illnesses: From tiredness to preparedness

9 January 2025
Author(s): Fabian Patauner, Raffaella Gallo, Emanuele Durante-Mangoni, Lorenzo Bertolino

In the wake of the coronavirus disease 2019 (COVID-19) pandemic, who would reasonably declare that a time will ever come «to close the book on infectious diseases»? Indeed, new viral threats are... more

The evolving role of head up tilt test: New protocol and indications for optimizing the care of syncope patients

3 January 2025
Author(s): Vincenzo Russo, Erika Parente, Angelo Comune, Gerardo Nigro, Michele Brignole

Dear Editor, we read with great interest the metanalysis by Guida et al. [1] about the diagnostic held of head up tilt test (HUTT) in patients with suspected vasovagal (VVS) syncope. The authors... more

Associations of cardiovascular health and exercise capacity with moderate-to-vigorous physical activity prior to enrolment to cardiac rehabilitation in coronary artery disease patients

30 December 2024
Author(s): Tim Kambič, Esmée A. Bakker, Thijs M.H. Eijsvogels, Vedran Hadžić, Mitja Lainscak

Exercise training is a core component of cardiac rehabilitation (CR) and is associated with improvement in (sub)maximal exercise capacity, quality of life, and a reduction in the risk of re-... more

The potential impact of educational attainment on NAFLD risk. Author's reply

14 December 2024
Author(s): Florian Koutny, Elmar Aigner, Bernhard Wernly

We thank Ke-qian Chen et al. and the European Journal of Internal Medicine for the opportunity to engage in a constructive discussion about the relationship between educational attainment and non-... more

Revisiting the association between air pollution and peripheral artery disease: Evidence from mendelian randomization analysis

14 December 2024
Author(s): Zhen Deng, Lincheng Duan, Kai Wang

We read with great interest the article by Di Blasi et al., published in the European Journal of Internal Medicine [1]. This well-designed study provides significant evidence on the association... more

Prognostic impact of different triggers in patients with Takotsubo syndrome and chronic obstructive pulmonary disease. Author's reply

9 December 2024
Author(s): Luca Arcari, Giacomo Tini, Beatrice Musumeci, Emanuele Barbato, Luca Cacciotti

We thank the authors for the interest in our study recently published in the journal [1]. In that, we focused specifically on patients with takotsubo syndrome (TTS) and chronic obstructive pulmonary... more

Measuring the risk of clinical adverse events (RISK ACE) by quantifying liver function: A patient-centric model

4 December 2024
Author(s): John Kittelson, Michael P. McRae, Gregory T. Everson

Identifying the patients with compensated advanced chronic liver disease (cACLD) who are at risk for clinical decompensation is a goal of clinical management [1]. Early detection of those at risk for... more

Clarifications and enhancements for cardiovascular risk study in metabolic dysfunction-associated steatotic liver disease

3 December 2024
Author(s): Yinfang Wu, Weixing Xu

This study by Shibata et al. [1] investigated the risk of major adverse cardiac events (MACE) in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and employed a... more

Extra-articular manifestations in rheumatoid arthritis: Incidence and predisposing factors

2 December 2024
Author(s): Jiaxu Wang, Jigong Wu, Liqi Li

The research by Lotta Ljung et al. [1] offers valuable insights into extra-articular manifestations (ExRA) in rheumatoid arthritis (RA) yet has room for improvement. The questionnaire-based approach... more

Prognostic impact of different triggers in patients with Takotsubo syndrome and chronic obstructive pulmonary disease

28 November 2024
Author(s): Anna Litwińska-Kmiecik, Agnieszka Zalewska, Alicja Wiśniewska

We read with great interest a recently published study by Luca Arcari, Giacomo Tini, Michela Zuccanti, et al. regarding clinical characteristics and outcomes of Takotsubo syndrome (TTS) in patients... more

Diagnostic yield of head-up tilt testing in suspected vasovagal syncope

28 November 2024
Author(s): Pietro Guida, Federica Troisi, Antonio Di Monaco, Massimo Iacoviello, Massimo Grimaldi

Vasovagal syncope (VVS) is the most frequent form of syncopal spells characterized by a reflex causing hypotension and often bradycardia, usually elicited by prolonged standing or exposure to... more

Enhancing cardiovascular risk management in rheumatoid arthritis: From medication adherence to multidisciplinary interventions

26 November 2024
Author(s): Shulin Dou, Wei Fang, Wei Wang, Hailiang Wang

We carefully read the article by Cacciapaglia et al. published in the European Journal of Internal Medicine [1]. This study reveals the suboptimal adherence to lipid-lowering therapy prescriptions in... more

Enhancing hypertension prevention research: Insights and opportunities for social work interventions

25 November 2024
Author(s): Ruyi Zhou, Senlin Ye, Jinli Liu, Lincheng Duan

We read with great interest the recent article by Hamaya et al. published in the European Journal of Internal Medicine [1]. The Authors conducted a comprehensive analysis of the impact of lifestyle... more

GLP-1 receptor agonists for the treatment of obstructive sleep apnea and obesity

15 November 2024
Author(s): Livia Romariz, Beatriz Araújo, Lucas M. Barbosa, Riddhi Jain, Carolina C. Porto Silva Janovsky, Obesity Study Group

Obstructive sleep apnea (OSA) syndrome is a common disorder of repeated upper airway collapse during sleep, leading to recurrent hypoxia and hypercapnia [1]. Continuous positive airway pressure (CPAP... more

Switching from hospital centered to community based, person centered and integrated social health and care systems; Mission impossible or key objective?

14 November 2024
Author(s): Lavinia Gentile, Giuseppe Liotta, Edoardo Carnevale, Stefano Orlando, Leonardo Palombi

Length of Stay (LOS) is a widely recorded metric used in hospital management and considered an important indicator of healthcare efficiency [1]. Despite its strategic value and one of the longest... more

The potential impact of educational attainment on NAFLD risk

11 November 2024
Author(s): Ke-qian Chen, Shu-zhi Wang, Zong-bao Wang, Hai-bo Lei, Xiang Liu

We read with great interest the article by Florian Koutny and his colleagues, recently published in the European Journal of Internal Medicine [1]. In this article, Florian Koutny and his colleagues... more

Characteristics of familial Mediterranean fever after 65 years of age

29 October 2024
Author(s): François Rodrigues, Léa Savey, Marion Delplanque, Laurence Cuisset, Sophie Georgin-Lavialle

Dear Editor,

Co-management hospitalist services for neurosurgery. Where are we?

27 September 2024
Author(s): Ombretta Para, Joel Byju Valuparampil, Alberto Parenti, Carlo Nozzoli, Alessandro Della Puppa

Dear Editor, the increase in the average age of the population and in the prevalence of chronic comorbidities has made healthcare extremely difficult and sometimes with difficult home management [1,2... more

Factors associated to multiple chronic conditions in internal medicine patients

20 September 2024
Author(s): Marco Vincenzo Lenti, Carmine Frenna, Alice Silvia Brera, Catherine Klersy, Gino Roberto Corazza, SMAC Study group

Dealing with patients with multiple chronic conditions (MCC) is certainly one of the most compelling healthcare challenges [1]. Most of the available data about MCC derive from large administrative... more

FIB-4 score association with operative outcomes, truth or fibs?

12 September 2024
Author(s): Brandon Stretton, Joshua Kovoor, Edmund Tse, Guy Maddern, Stephen Bacchi, Study group investigators

In recent years, liver disease has become established as a significant predictor of poor perioperative outcomes [1]. Despite declining rates of hepatitis B and hepatitis C-related morbidity and... more

Diagnostic value of pleural calprotectin in differentiating complex parapneumonic effusions

6 September 2024
Author(s): Ourania S. Kotsiou, Nikolaos D. Karakousis, Dimitrios Papagiannnis, Garyfallia Perlepe, Konstantinos I. Gourgoulianis

Dear Editor,

Oh no, all we needed was monkeypox!

3 September 2024
Author(s): Giuseppe Lippi

Four years after the spread of the coronavirus disease 2019 (COVID-19) pandemic, with a worldwide epidemiology largely under control thanks to widespread immunity against severe acute respiratory... more

Original Article

Opt-In versus opt-out for the secondary use of routinely recorded health data: A randomized controlled trial

29 January 2025
Author(s): Merel Hermus, Celinde H. Scharloo-Karels, M. Arfan Ikram, Eleni-Rosalina Andrinopoulou, Dimitris Rizopoulos, Dennis H. Marck, Michelle Michels, Folkert van Kemenade

Optimal data availability is crucial for continuous improvement and innovation in healthcare. In moving toward learning health systems, data need to be constantly generated, reused and learned from.... more

Prediction of mortality in heart failure by machine learning. Comparison with statistical modeling

28 January 2025
Author(s): Domenico Scrutinio, Federica Amitrano, Pietro Guida, Armando Coccia, Gaetano Pagano, Gianni D'addio, Andrea Passantino

Heart failure (HF) is a complex, increasingly prevalent syndrome burdened by poor quality of life, compromised capability to accomplish activities of daily living, high healthcare costs, and still... more

Comparative effectiveness of bictegravir versus dolutegravir, raltegravir, and efavirenz-based antiretroviral therapy among treatment-naïve individuals with HIV

21 January 2025
Author(s): Isaac Núñez, Yanink Caro-Vega, Conor MacDonald, Juan Luis Mosqueda, Alicia Piñeirúa-Menéndez, Anthony A. Matthews

Bictegravir or dolutegravir (two integrase strand inhibitors) in combination with two nucleoside reverse transcriptase inhibitors are recommended as first-line antiretroviral therapy [1,2].Both have... more

The impact of hypoalbuminemia on the long-term prognosis of patients with acute heart failure: The modifying role of carbohydrate antigen 125

3 January 2025
Author(s): Pau Llàcer, François Croset, Rafael de la Espriella, Marina García, Gema Miñana, Jorge Campos, Enrique Santas, Carlos Pérez, Miguel Lorenzo, Alberto Pérez, Gonzalo Núñez, Esteban Pérez, Luis Manzano, Julio Núñez

The main novelty of the present study is:

Prevalence and impact of multidrug resistance in a cohort of patients admitted to emergency department for urinary tract-infections: The UTILY study, a prospective multicentre study

30 December 2024
Author(s): Lorenzo Onorato, Enrico Allegorico, Margherita Macera, Caterina Monari, Biagio Migliaccio, Carmine Nasta, Maria Teresa Florio, Roberta Sciorio, Fabio Giuliano Numis, Giovanna Guiotto, Mauro Giordano, Rosa Raucci, Ferdinando Dello Vicario, Rodolfo Nasti, Antonio Voza, Nicola Coppola, for UTILY study group

Urinary tract infections (UTIs) are among the most frequent bacterial infections both in community and healthcare settings [1]. The Global Burden of Diseases (GBD) has estimated an incidence of 0.4... more

The effect of a new thinking guidance of OPACCUS for shock on the 30-day mortality: A multicenter, prospective, observational, cohort study

26 December 2024
Author(s): Yi Li, Tongjuan Zou, Xueying Zeng, Yao Qin, Ran Zhou, Lianghai Cao, Jian Hu, Xianying Lei, Qionglan Dong, Yiwei Qin, Ge Zhang, Yan Kang, Bo Wang, Zhongwei Zhang, Xiaoting Wang, Yangong Chao, Wanhong Yin, Critical Care Ultrasound Study Group (CCUSG); Committee on Critical Care Ultrasound and Hemodynamics (CCUSH, SCIMEA)

Shock is the final common pathway before death and a constant focus of ICU physicians due to its high morbidity and mortality [1] (ranging from 27 % to 60 %) in critically ill patients. Recent... more

Effects of valsartan vs amlodipine and achieved lower blood pressure on the incidence of end-stage kidney disease: The VALUE Trial

18 December 2024
Author(s): Eirik Olsen, Kenneth Jamerson, Roland E. Schmieder, Camilla L. Søraas, Julian E. Mariampillai, Giuseppe Mancia, Sverre E. Kjeldsen, Sondre Heimark, Maria H. Mehlum, Knut Liestøl, Anne C.K. Larstorp, Lene V. Halvorsen, Aud Høieggen, Michel Burnier, Morten Rostrup, Stevo Julius, Michael A. Weber

There is a strong relationship between high blood pressure (BP) and the risk of developing chronic kidney disease (CKD) [1–8]. In people with CKD, a high BP is associated with a faster decline of... more

Length of hospital stay, delayed pneumonia diagnosis and post-discharge mortality. The Pneumonia in Italian Acute Care for Elderly units (PIACE)-SIGOT study

18 December 2024
Author(s): Filippo Luca Fimognari, Paolo Fabbietti, Francesco Baffa Bellucci, Andrea Corsonello, Roberto Ricchio, Massimo Rizzo, Olga Cuccurullo, Alberto Ferrari, Lorenzo Palleschi, PIACE-SIGOT Investigators

The ageing of populations in high-income countries has increased the number of vulnerable older persons requesting medical care, including care for acute and complex illnesses that warrant medical... more

Effect of continuous positive airway pressure on non-fatal stroke and paroxysmal atrial fibrillation recurrence in obstructive sleep apnoea elderly patients

16 December 2024
Author(s): Valentino Condoleo, Giandomenico Severini, Giuseppe Armentaro, Mattea Francica, Giulia Crudo, Mario De Marco, Francesco Maruca, Guglielmo Ciaccio, Carlo Fuoco, Carlo Alberto Pastura, Marcello Divino, Corrado Pelaia, Egidio Imbalzano, Mario Bo, Andrea Ungar, Angela Sciacqua

Obstructive sleep apnoea (OSA) is a respiratory disorder characterised by repeated events of upper airway collapse leading to airflow limitation [1]. OSA is often under-recognised, and if untreated,... more

Exploring phenotypes to improve long-term mortality risk stratification in obstructive sleep apnea through a machine learning approach: an observational cohort study

16 December 2024
Author(s): Pasquale Tondo, Giulia Scioscia, Sebastien Bailly, Roberto Sabato, Terence Campanino, Piera Soccio, Maria Pia Foschino Barbaro, Crescenzio Gallo, Jean-Louis Pépin, Donato Lacedonia

Obstructive sleep apnea (OSA) is a highly prevalent [1] and heterogeneous sleep disorder [2], characterized by frequent collapses of the upper airway that induce intermittent hypoxia and sleep... more

Evaluations of metabolic and innate immunity profiles in subjects with familial hypercholesterolemia with or without subclinical atherosclerosis

13 December 2024
Author(s): Giosiana Bosco, Francesco Di Giacomo Barbagallo, Maurizio Di Marco, Sabrina Scilletta, Nicoletta Miano, Stefania Capuccio, Marco Musmeci, Stefania Di Mauro, Agnese Filippello, Alessandra Scamporrino, Antonino Di Pino, Luis Masana, Francesco Purrello, Salvatore Piro, Roberto Scicali

Atherosclerosis is a chronic and progressive process promoted by several environmental and genetic factors [1,2]; among these, low-density lipoprotein cholesterol (LDL-C) has been recognized to have... more

Long-term follow-up of hereditary hemorrhagic telangiectasia patients without significant pulmonary right-to-left shunt at screening

11 December 2024
Author(s): Bernat Villanueva, Miguel Ángel Sánchez-Corral, Esther Alba, Queralt Ordi, Yolanda Ruiz, Raquel Torres-Iglesias, Alejandro Portillo, Adriana Iriarte, Cristina Monforte, Enric Gamundí, Xavier Pintó, Jesús Ribas, Antoni Riera-Mestre

Hereditary hemorrhagic telangiectasia (HHT) is a vascular genetic rare disease (ORPHA: 774) characterized by systemic telangiectases and larger vascular malformations [1]. HHT can be diagnosed using... more

Different impact of chronic kidney disease in older patients with heart failure according to frailty

7 December 2024
Author(s): Pablo Díez-Villanueva, César Jiménez-Méndez, Ángel Pérez-Rivera, Eduardo Barge Caballero, Javier López, Carolina Ortiz, Clara Bonanad, Josebe Goirigolzarri, Alberto Esteban Fernández, Marta Cobo, Nuria Montes, Albert Ariza-Solé, Manuel Martínez-Sellés, Fernando Alfonso

Chronic kidney disease (CKD) affects up to 10 % of the general population, being one-third of these individuals over 65 years old [1]. A bidirectional interaction, has been described between CKD and... more

Association between long-term exposure to air pollution and incidence of peripheral artery disease: Evidence from a longitudinal study

5 December 2024
Author(s): Chiara Di Blasi, Federica Nobile, Alberto Maria Settembrini, Massimo Stafoggia, Marina Davoli, Paola Michelozzi, Matteo Renzi, Pier Mannuccio Mannucci

Cardiovascular disease (CVD) is one the most frequent cause of death and disability globally, including Europe. CVD causes 3.9 million annual deaths in the European Union and the loss of 26 million... more

Comorbidity patterns and the risk of injurious falls in older people with atrial fibrillation: Findings from a Swedish nation-wide population-based study

30 November 2024
Author(s): Caterina Trevisan, Cecilia Damiano, Lu Dai, Amaia Calderón-Larrañaga, Jonas W. Wastesson, Kristina Johnell, Cheïma Amrouch, Graziano Onder, Alessandra Marengoni, Riccardo Proietti, Gregory Y H Lip, Søren P Johnsen, Mirko Petrovic, Davide Liborio Vetrano, on behalf of the AFFIRMO Consortium

Atrial fibrillation (AF) is the most common arrhythmia in the general population, increasing by 30 % over the last 20 years primarily as a result of the better diagnostics and ageing population [1],... more

Clinical characteristics and outcomes of Takotsubo syndrome in patients with chronic obstructive pulmonary disease

7 November 2024
Author(s): Luca Arcari, Giacomo Tini, Michela Zuccanti, Giovanni Camastra, Alessandro Cianca, Emanuela Belmonte, Giulio Montefusco, Riccardo Scirpa, Claudia Malerba, Fabrizio Lupparelli, Matteo Sclafani, Viviana Maestrini, Beatrice Musumeci, Emanuele Barbato, Luca Cacciotti

Takotsubo syndrome (TTS) is an acute heart failure syndrome characterized by a transient impairment of systolic function [1]. Adverse outcomes have been described both in the acute phase and, despite... more

Modifiable lifestyle factors in the primordial prevention of hypertension in three US cohorts

6 November 2024
Author(s): Rikuta Hamaya, Molin Wang, Ellen Hertzmark, Nancy R Cook, JoAnn E Manson, Qi Sun, Meir J Stampfer, Kenneth J. Mukamal, Gary Curhan, Eric B Rimm

Hypertension is a leading cause of cardiovascular diseases (CVD). The prevalence has doubled from 1990 to 2019 [1] and now impacts almost half of the US adult population [2], and the condition... more

Clinically relevant bleeding according to location of metastases in cancer-associated thrombosis

28 October 2024
Author(s): Victor Garcia-Garcia, Maria Barca-Hernando, Sergio Lopez-Ruz, Carmen Rosa-Linares, Teresa Elias-Hernandez, Remedios Otero-Candelera, Henry Andrade-Ruiz, Luis Jara-Palomares

Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT) and pulmonary embolism (PE), is a frequent complication in patients with cancer [1]. It is estimated that 20–30 % of VTE cases are... more

External validation of a prognostic score to identify low-risk outpatients with acute deep venous thrombosis in the lower limbs

14 October 2024
Author(s): Francisco Galeano-Valle, Rubén Alonso-Beato, Sergio Moragón-Ledesma, Tatiana Pire-García, Olaya Huergo-Fernández, Lucía Ordieres-Ortega, Crhistian-Mario Oblitas, Luis Antonio Alvarez-Sala Walther, Pablo Demelo-Rodríguez

Deep vein thrombosis (DVT) and pulmonary embolism (PE) stand as the primary manifestations of venous thromboembolism (VTE) [1-3]. Nonetheless, the absence of national surveillance systems for VTE... more

Hyperchloremic metabolic acidosis potentially benefiting sodium bicarbonate therapy: A multi-center cohort study

11 October 2024
Author(s): Lingfei Tong, Shuiyan Wu, Deping Li, Yanmei Cao, Huaqing Liu

Metabolic acidosis is a type of acid-base imbalance that significantly impacts prognosis. It can be caused by poisoning, infections, surgeries, acute and chronic renal failure, diabetic ketosis, and... more

Practice Guidelines

Treatment of hospitalized patient with hyperglycemia: An EFIM critically appraised and adapted guideline

9 December 2024
Author(s): Oğuz Abdullah Uyaroğlu, Ieva Ruza, Jan Skrha, Dimitrios Patoulias, Sebastjan Bevc, Biljana Ivanovska Bojadjiev, Ricardo Gómez-Huelgas, Jörg Bojunga, Wiktoria Lesniak, Juana Carretero-Gómez, Julio Wacker, Luis M. Pérez-Belmonte, Dror Dicker, Tadej Petreski, Ignacio Marín-León

Over the past decade, diabetes mellitus (DM) has emerged as a growing epidemic with an estimated global prevalence of 10.5 % (537 million people) in 2021, according to the International Diabetes... more

Review Article

Chronic obstructive pulmonary disease: A narrative synthesis of its hallmarks for palliative care clinicians

9 January 2025
Author(s): Jacopo D'Andria Ursoleo, Alice Bottussi, Donald R. Sullivan, Corrado D'Andria, Natalia Smirnova, William E. Rosa, Stefano Nava, Fabrizio Monaco

Chronic obstructive pulmonary disease (COPD) accounts for approximately 55 % of cases of respiratory diseases and is now the third cause of both death and morbidity worldwide [1]. Its prevalence is... more

Practical management of severe acute pancreatitis

29 November 2024
Author(s): Karim Hamesch, Marcus Hollenbach, Lucía Guilabert, Tobias Lahmer, Alexander Koch

Diagnosis of acute pancreatitis (AP) is based on the Revised Atlanta Classification[1] (Table 1) requiring at least two of three criteria: i) typical epigastric pain radiating to the back, ii) serum... more

Transforming organ donation and transplantation: Strategies for increasing donor participation and system efficiency

20 November 2024
Author(s): David B. Olawade, Sheila Marinze, Nabeel Qureshi, Kusal Weerasinghe, Jennifer Teke

Organ transplantation stands as one of the most significant advancements in modern medicine, providing life-saving solutions for patients with end-stage organ failure [1]. From the first successful... more

New strategies for the treatment of hyperkalemia

2 November 2024
Author(s): Stefano Masi, Herman Dalpiaz, Sara Piludu, Federica Piani, Giulia Fiorini, Claudio Borghi

Potassium (K+) is the most abundant cation in the body (50–75 mEq/L/kg body weight). Under physiological conditions, approximately 98 % of total body K+ is located in the intracellular space and only... more

Gliflozines use in heart failure patients. Focus on renal actions and overview of clinical experience

21 September 2024
Author(s): Edoardo Gronda, Massimo Iacoviello, Arduino Arduini, Manuela Benvenuto, Domenico Gabrielli, Mario Bonomini, Luigi Tavazzi

In the past decades impressive progress in heart failure (HF) treatment has been achieved by adoption of therapeutic tools ranging from renin angiotensin system antagonists to beta blocking agents,... more

Newsletters

Stay informed on our latest news!

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

randomness