This study by Shibata et al. [1] investigated the risk of major adverse cardiac events (MACE) in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and employed a classification and regression tree (CART) model for risk stratification based on age and the number of risk factors. The research underscores the importance of considering both age and the cumulative burden of risk factors in predicting MACE risk among individuals with MASLD. While the findings are insightful, some aspects warrant further clarification to enhance their impact and guide future investigations.
