Published: 1 February 2025
Author(s): Mohamed G Shiha, David S Sanders
Issue: March 2025
Section: Invited Review Article

Coeliac disease is a chronic immune-mediated disorder triggered by gluten ingestion in genetically predisposed individuals [1]. It is characterised by immune-mediated inflammation and damage to the small intestinal mucosa, which leads to impairment of nutrient absorption and a wide range of gastrointestinal and systemic symptoms [2]. Historically, coeliac disease was primarily suspected in Caucasian children with malabsorptive symptoms such as diarrhoea, weight loss and failure to thrive. However, it is now recognised to affect all ages, ethnicities and with subtle gastrointestinal symptoms or non-typical clinical presentations, including fatigue, anaemia, and neurological symptoms [3].

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