Pulmonary embolism (PE) is the third leading cause of cardiovascular death after myocardial infarction and stroke [1]. As already described, patients with cardiovascular disease (CVD) have a higher prevalence of PE [2,3]. However, limited data regard the short-term survival of subjects with history of significant coronary artery disease (CAD) after acute PE is available. For this reason, we sought to evaluate the prevalence and the impact of significant CAD on an 8-month mortality after acute PE.