The ongoing Zika virus (ZIKV) outbreak in South and Central America has rapidly focused global attention due to its association with clusters of congenital malformations such as microcephaly, and neurological disorders and impending 2016 Olympic Games in Rio, Brazil [1]. It was declared a global emergency by the World Health Organization and the ensuing flurry of research is defining the complexity of the epidemiology and pathogenesis of ZIKV. The main mode of transmission to humans is through the bite of an infected Aedes spp.