Published: 1 February 2021
Author(s): M. Schils, A. Betrains, S. Vanderschueren, X. Bossuyt, D. Blockmans
Issue: May 2021
Section: Letter to the Editor

IgG4-Related Disease (IgG4-RD) is a systemic inflammatory disorder with potential to affect almost every organ [1]. The diagnosis of IgG4-RD is primarily based upon characteristic histological findings combined with clinical and biochemical results. Elevated serum IgG4 levels (sIgG4) can be seen in up to 5% of the normal population [2]. IgG4 elevation is not regarded as an exclusive feature of IgG4-RD but is seen in many other disorders, mostly of a chronic inflammatory nature [3–6]. Our retrospective study aims to determine the diverse diagnostic entities associated with elevated sIgG4.

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