May 2021

105 Articles

No Section

Very low lipoprotein(a) and increased mortality risk after myocardial infarction

7 May 2021
Author(s): Peter Wohlfahrt, Dominik Jenča, Vojtěch Melenovský, Janka Franeková, Antonín Jabor, Marek Šramko, Vladimír Staněk, Michael Želízko, Rudolf Poledne, Jan Piťha, Věra Adámková, Josef Kautzner

Lipoprotein(a) (Lp[a]) consists of a lipoprotein moiety identical to low density lipoprotein (LDL) cholesterol, as well as a plasminogen-similar glycoprotein apo(a). About 90% of a person's Lp(a)... more

Integrated approach to bronchoalveolar lavage cytology to distinguish interstitial lung diseases

28 April 2021
Author(s): Laura Bergantini, Miriana d'Alessandro, Paolo Cameli, Anna Perrone, Behar Cekorja, Bianca Boncompagni, Maria Antonietta Mazzei, Piersante Sestini, Elena Bargagli

Broncho-alveolar lavage (BAL) is a safe diagnostic procedure, useful for differentiating fibrotic lung disorders and for excluding malignancy and infection [1–5]. Together with chest high resolution... more

Midregional proadrenomedullin safely reduces hospitalization in a low severity cohort with infections in the ED: a randomized controlled multi-centre interventional pilot study

24 April 2021
Author(s): Juan Gonzalez del Castillo, Carlota Clemente-Callejo, Ferran Llopis, Andreea Irimia, Fernando Oltra-Hostalet, Cindy Rechner, Andrej Schwabe, Verónica Fernandez-Rodriguez, Catalina Sánchez-Mora, Jordi Giol-Amich, Belén Prieto-García, Ignasi Bardés-Robles, Maria Dolores Ortega-de Heredia, Eric Jorge García-Lamberechts, Carmen Navarro-Bustos, INFURG-SEMES investigators

Patients with suspected infections presenting to the emergency department (ED) can potentially develop life-threatening conditions [1]. An early assessment of disease severity and the risk of disease... more

A case of suprapubic pain

20 April 2021
Author(s): Ankita Aggarwal, Anubhav Jain

A 71-year-old male with a past medical history of prostate cancer s/p radiation treatment seven years ago. He presented to the emergency department with acute onset pain in the suprapubic region. He... more

Weight-adjusted versus fixed dose heparin thromboprophylaxis in hospitalized obese patients: A systematic review and meta-analysis

19 April 2021
Author(s): Davide Ceccato, Angelo Di Vincenzo, Claudio Pagano, Raffaele Pesavento, Paolo Prandoni, Roberto Vettor

Venous thromboembolism (VTE) is a multi-factorial disease with high morbidity and mortality rates. As it has been reported to occur in about 100–200 cases/100,000 inhabitants per year [1], VTE... more

Safety of treatment with chloroquine and hydroxychloroquine: A ten-year systematic review and meta-analysis

5 April 2021
Author(s): Fernando Luiz Barros Edington, Sandra Rocha Gadellha, Mittermayer Barreto Santiago

Previously known as SN7618, chloroquine has been used since the early 1940s for the treatment of malaria [1]. In 1946 Loeb F. et al., in a statement approved by the board for coordination of malarial... more

The efficacies of entecavir and tenofovir in terms of enhancing prognosis after curative treatment of hepatitis B virus–related hepatocellular carcinoma

30 March 2021
Author(s): Ji Hyun Lee, Beom Kyung Kim, Soo Young Park, Won Young Tak, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Dong Hyun Sinn, Seung Up Kim

Whether entecavir (ETV) or tenofovir disoproxil fumarate (TDF) affords the better prognosis after curative treatment of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) remains unclear... more

Influence of gender on the performance of urine dipstick and automated urinalysis in the diagnosis of urinary tract infections at the emergency department

25 March 2021
Author(s): S.J.M. Middelkoop, L.J. van Pelt, G.A. Kampinga, J.C. ter Maaten, C.A. Stegeman

Urinary tract infections (UTIs) are generally more common in women compared to men [1-3]. Beside incidence, also differences in presentation and course of UTI exist between men and women. This is due... more

When and how did the air come in?

21 March 2021
Author(s): Jin Ikeda

An 84-year-old man with cognitive dysfunction was taken to the emergency room because of a change in consciousness. He came in with a Glasgow Coma Scale (GCS) score of E4V4M5. According to his family... more

SGLT2 inhibitors should be recommended in patients with one or more of the three diseases: type 2 diabetes, chronic kidney disease, and HFrEF

12 March 2021
Author(s): Li-Min Zhao, Liang-Liang Ding, Ze-Lin Zhan, Mei Qiu

Patoulias and colleagues have made a relevant commentary entitled “Chronic kidney disease and diabetes status do not affect efficacy of SGLT-2 inhibitors in patients with heart failure with reduced... more

Infective endocarditis in patients with solid organ transplantation. A nationwide descriptive study

5 March 2021
Author(s): Manuel Martínez-Sellés, Maricela Valerio-Minero, María Carmen Fariñas, Hugo Rodríguez-Abella, María Luisa Rodríguez, Aristides de Alarcón, Encarnación Gutiérrez-Carretero, Manuel Cobo-Belaustegui, Miguel Ángel Goenaga, Asunción Moreno-Camacho, Fernando Domínguez, Laura García-Pérez, Laura Domínguez-Pérez, Patricia Muñoz, on behalf of the Spanish Collaboration on Endocarditis—Grupo de Apoyo al Manejo de la Endocarditis infecciosa en ESpaña (GAMES)

Infective endocarditis (IE) is a serious condition with a poor prognosis [1,2]. Solid organ transplantation (SOT) is an established and practical definitive treatment option for patients with end-... more

Mid-term Prognostic Implication of hospitalized COVID-19 patients with Prior Heart Failure diagnosis

25 February 2021
Author(s): Pau Llàcer, Luis Manzano, Cristina Fernández, Mari Carmen Moreno, Julio Núñez

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that was diagnosed in late 2019 in Wuhan (China)[1]. It has spread... more

Estimated glomerular filtration rate and renal resistive index as possible predictive markers of mortality in systemic sclerosis

13 February 2021
Author(s): Giorgia Leodori, Chiara Pellicano, Antonietta Gigante, Edoardo Rosato

Systemic sclerosis (SSc) is an autoimmune disease characterized by immune system activation, microvascular damage and fibrosis of skin and internal organs. Renal manifestations of SSc include... more

Risk factors and current management of venous thromboembolism in patients with primary immune thrombocytopenic purpura.

7 February 2021
Author(s): Marco Tana, Claudio Tana, Giulia Rizzo, Fabrizio Ricci, Ettore Porreca

immune thrombocytopenic purpura (ITP) is a rare hematologic disorder characterized by isolated thrombocytopenia due to platelet destruction, without abnormalities of erythrocyte or leukocyte number... more

The 3Ds – Discussion, diagnosis and direction: Elements for effective obesity care by healthcare professionals

23 January 2021
Author(s): Assim A. Alfadda, Ian D. Caterson, Walmir Coutinho, Ada Cuevas, Dror Dicker, Jason C.G. Halford, Carly A. Hughes, Masato Iwabu, Jae-Heon Kang, Rita Nawar, Ricardo Reynoso, Nicolai Rhee, Georgia Rigas, Javier Salvador, Verónica Vázquez-Velázquez, Paolo Sbraccia

Obesity is a chronic disease associated with multiple health complications [1]. Furthermore, the COVID-19 pandemic has made evident the impact obesity can have on health outcomes, whereby people with... more

Pulmonary congestion and mortality during venoarterial extracorporeal membrane oxygenation (VA-ECMO): does time matter?

19 December 2020
Author(s): Pieter S. van der Wal, Peter-Paul Zwetsloot, Olaf L. Cremer, Dirk W. Donker, Christiaan L. Meuwese

In a recent edition of this Journal, an intriguing study was published which examined the association between (development of) pulmonary congestion (PC) and mortality in patients with post-cardiotomy... more


Patients with Atrial Fibrillation receiving NOACs: The boundary between appropriate and inappropriate dose

7 May 2021
Author(s): Maria Cristina Vedovati, Michela Giustozzi, Maurizio Paciaroni

Since their introduction in 2010, non-vitamin K oral anticoagulants (NOACs) changed the landscape of stroke prevention in patients with atrial fibrillation (AF). Because of their favorable benefit-... more

The Times They Are A-Changin´: Antithrombotic strategies in patients with acute coronary syndrome undergoing coronary stenting who have concomitant atrial fibrillation

29 April 2021
Author(s): Trygve S. Hall, Dan Atar

Atrial fibrillation (AF) is a highly prevalent condition associated with an increased risk of cardioembolic strokes. Consequently, oral anticoagulation therapy has been established as a cornerstone... more

SGLT2 inhibitors: Do we need other evidences?

6 April 2021
Author(s): Angelo Avogaro

The five cardiovascular outcome trials (CVOT) conducted in patients with type 2 diabetes mellitus so far have shown that renal sodium-glucose cotransporters two inhibitors (SGLT2i) are cardiovascular... more

Colorectal cancer and cardiovascular diseases: Are we closing the gap between knowledge and action?

26 March 2021
Author(s): Mario Mandalà, Fausto Roila

Colorectal cancer (CRC) and cardiovascular diseases (CVD) are amongst the two leading causes of death in western countries and have dramatic impact on the financial sustainability of the health... more

Colorectal cancer and cardiovascular disease: A thrombo-inflammatory link?

26 March 2021
Author(s): Hugo ten Cate

One of the few advantages of the Covid-19 pandemic is a renewed focus on the benefits of a healthy lifestyle, as a way to reduce both the risk of contracting SARS-CoV-2 infection and, in case of... more

Venous lactate: The new “magic marker” for stratification in intermediate-risk pulmonary embolism?

18 March 2021
Author(s): Nicolas Meneveau

Risk stratification in patients with acute pulmonary embolism (PE) is essential to guide the choice of appropriate therapy. The stratification of risk is first and foremost based on the presence of... more

When is it reasonable to extrapolate during a pandemic?: The case of broad UK labeling for AstraZeneca COVID-19 vaccine

18 March 2021
Author(s): Rafael Dal-Ré, Rita Banzi

Amid an unprecedented surge of COVID-19 cases in the UK, with an increasing number due to a novel more infectious SARS-CoV-2 variant,[1] the UK regulatory agency (MHRA) granted emergency approval to... more


Implementation of Guidelines on Atrial Fibrillation Management in the Global Arena: So Many Actors on Stage!

7 April 2021
Author(s): Riccardo Cappato

According to the seminal definition by the Institute of Medicine released in 1990, clinical guidelines represent “systematically developed statements to assist practitioner and patient decisions... more

Internal Medicine Flashcard

No more than meets the eye

1 April 2021
Author(s): Louis-Philippe Dormegnie, Adrien Henry, Jean-Hugues Salmon, Yohan N'Guyen

A 33-year old Ivorian woman was admitted for fever and thrombocytopenia. She had been previously treated in France by tocilizumab then anti TNF-α for rheumatoid arthritis since 7 and 2 years... more

Atypical cause of dysphagia

23 March 2021
Author(s): Dhairya A Lakhani, Aneri B Balar, Abdul R Tarabishy

A 27-years-old male presented with progressively worsening dysphagia for four years. The dysphagia was worse for solids, and for the past three months, the patient had restricted his diet to liquids... more

Atypical cause of episodic abdominal pain and unintentional weight loss

21 March 2021
Author(s): Dhairya A. Lakhani, Aneri B. Balar, Abdul R. Tarabishy

A 23-year-old female with past medical history of generalized anxiety disorder and migraine presents to the clinic with unintentional weight loss of approximately 20 lbs and chronic episodic... more

The long toenail sign in older adults

21 March 2021
Author(s): Kirstyn James, Ariela R Orkaby, Andrea Wershof Schwartz

A 78 year old male attended a geriatric medicine outpatient clinic accompanied by his son. He described a history of falls, memory impairment and difficulty completing activities of daily living... more

Letter to the Editor

Validation of the AF-ESUS score to identify patients with embolic stroke of undetermined source and low risk of device-detected atrial fibrillation

2 May 2021
Author(s): Alkisti Kitsiou, Dimitrios Sagris, Wolf-Rüdiger Schäbitz, George Ntaios

During the recent years, the term ESUS (embolic stroke of undetermined source) is used to describe patients with ischemic stroke for whom the source of embolism remains undetected despite recommended... more

Convalescent plasma in the management of COVID-19 pneumonia

29 April 2021
Author(s): Ayman Elbadawi, Mina Shnoda, Maryrose Laguio-Vila, Mamas A. Mamas, Islam Y. Elgendy

Few therapeutic agents have been proven to be effective in the management of COVID-19 pneumonia in randomized trials, thus the treatment options for this condition remain limited [1,2]. Convalescent... more

Healthcare students: should they be prioritized for COVID-19 vaccination?

29 April 2021
Author(s): Michele Augusto Riva, Maria Emilia Paladino, Michael Belingheri

Not requested.

Impact of rate control in hospitalized patients with atrial fibrillation and sepsis

24 April 2021
Author(s): Giulio Francesco Romiti, Marco Proietti

Sepsis is defined as a dysregulated host response to several types of infections [1], still representing a challenging issue in Medicine. Atrial Fibrillation (AF) frequently occurs in patients with... more

Iron deficiency in chronic myocarditis: Assessment and prognostic significance

20 April 2021
Author(s): Giovanni Peretto, Simone Sala, Clara Camaschella

Iron deficiency (ID) and associated anemia (IDA) represent major comorbidities in chronic diseases [1]. However, their prevalence and prognostic significance have never been investigated in... more

Prevalence of proximal deep vein thrombosis in hospitalized COVID-19 patients

8 April 2021
Author(s): Guillaume Reichert, Vincent Bunel, Dora Dreyfuss, Loukbi Saker, Antoine Khalil, Hervé Mal

Severe acute respiratory syndrome coronavirus 2(SARS-COV-2) is a novel virus that has spread worldwide since the end of 2019. Although a proportion of patients remains asymptomatic, the virus may be... more

Intermediate dose thromboprophylaxis in SARS-CoV-2 related venous thrombo embolism

26 March 2021
Author(s): Zahra Haider, Kanendran Rajalingam, Tanveer Khalid, Dilip Oswal, Akshay Dwarakanath

SARS-CoV-2 illness is associated with both pulmonary and extra pulmonary complications with hypoxemia being a marker of severity [1]. Evidence has shown an increase in venous thromboembolism (VTE)... more

Pneumothorax/pneumomediastinum in non-intubated COVID-19 patients: Differences between first and second Italian pandemic wave

18 March 2021
Author(s): Diego Palumbo, Corrado Campochiaro, Alessandro Belletti, Alessandro Marinosci, Lorenzo Dagna, Alberto Zangrillo, Francesco De Cobelli, for the COVID-BioB Study Group

Pneumothorax (PNX) and pneumomediastinum (PMD) have been frequently observed in mechanically ventilated patients with coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome (... more

Pre-admission atrial fibrillation in COVID-19 patients: Prevalence and clinical impact

18 March 2021
Author(s): Vincenzo Russo, Angelo Silverio, Fernando Scudiero, Pierpaolo Di Micco, Marco Di Maio

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly pathogenic human coronavirus recently recognized as the cause of the coronavirus disease 2019 (COVID-19). Italy is one of the... more

The power of choice: Experimental evidence that freedom to choose a vaccine against COVID-19 improves willingness to be vaccinated

18 March 2021
Author(s): Philipp Sprengholz, Sarah Eitze, Lars Korn, Regina Siegers, Cornelia Betsch

Ending the COVID-19 pandemic will require rapid and large-scale uptake of vaccines against the disease. The European Commission has authorized three vaccines so far, and first doses have already been... more

Loneliness that destroys and upsets: A lesson from and beyond COVID-19

14 March 2021
Author(s): Christian Bracco, Remo Melchio, Elena Migliore, Chiara Marrale, Luigi Fenoglio

“I've often come up against the bad part about living”. A famous poem by the great poet Eugenio Montale represents well the situation of elderly patients admitted to our hospitals in recent months.

Hellenic Postprandial Lipemia Study (HPLS): Results from the Pre-treatment Postprandial Lipemia

10 March 2021
Author(s): Petros Kalogeropoulos, Helen Bilianou, Vana Kolovou, Athanasios Manolis, Genovefa D. Kolovou

Although fasting triglyceride (TG) levels are routinely measured in clinical practice, studies indicate that postprandial hypertriglyceridemia may be also related to atherosclerosis [1]. Currently,... more

Usefulness of step down units to manage survivors of critical Covid-19 patients

6 March 2021
Author(s): Piero Ceriana, Michele Vitacca, Mara Paneroni, Stefano Belli, Nicolino Ambrosino

The Coronavirus 2 (Covid-19) associated severe acute respiratory failure (ARF) has led to a huge number of admissions to intensive care units (ICU) with high fatality rates and shortage of beds. We... more

Is the “beach position” of value during the “eyeball” assessment of patients?

4 March 2021
Author(s): Alfred Lumala, John Kellett, Jelmer Alsma, Christian H Nickel

The rapid identification at low cost of patients at risk is particularly important in emergency departments in low- and middle-income countries, which may lack experienced emergency healthcare... more

DNA genotyping of the ABO gene showed a significant association of the A-group (A1/A2 variants) with severe COVID-19.

25 February 2021
Author(s): Juan Gómez, Guillermo M Albaiceta, Marta García-Clemente, José M. García-Gala, Eliecer Coto

The coronavirus disease 2019 (COVID-19) is caused by the new beta-coronavirus SARS-CoV-2. The virus has spread worldwide causing a pandemic with millions of infected. The adverse outcome is... more

Acute coronary syndrome-related hospital admissions during and after lockdown in Southern Germany

22 February 2021
Author(s): Stefan Brunner, Bruno C. Huber, Georg Kanz, Viktoria Bogner-Flatz

The Covid-19 pandemic has affected all aspects of our daily life and challenged our health care system in an unprecedented manner [1]. The crisis even altered the health behavior resulting in... more

Chronic kidney disease and diabetes status do not affect efficacy of SGLT-2 inhibitors in patients with heart failure with reduced ejection fraction

22 February 2021
Author(s): Dimitrios Patoulias, Christodoulos Papadopoulos, Michael Doumas

We have read with great interest the meta-analysis performed by Qiu et al. [1] published in the European Journal of Internal Medicine, assessing the cardio-renal efficacy of different sodium-glucose... more

Effectiveness and safety of high and low dose NOACs in patients with atrial fibrillation

18 February 2021
Author(s): Irene Marzona, Marco Proietti, Pierluca Colacioppo, Andreana Foresta, Marta Baviera

Non-vitamin K antagonist oral anticoagulants (NOACs) were marketed in 2011 as alternatives to Vitamin K Antagonists (VKA) for treatment of thromboembolic risk in atrial fibrillation (AF) patients.... more

Cor homini lupus? Identification of risk factors implicated in cardiovascular events in patients with Systemic Lupus Erythematosus in Romania

17 February 2021
Author(s): Ergina Syrigou, Dimitrios V. Moysidis, Andreas S. Papazoglou, Christos Tsagkaris, Anna Maria Louka, Anca Bobirca

Cardiovascular disease (CVD) accounts for up to 35% of mortality in patients with systemic lupus erythematosus (SLE) [1]. Emerging evidence supports that SLE disease activity is associated with up to... more

Treating life-threatening TAFRO syndrome with interleukin-1 inhibition

16 February 2021
Author(s): Marco Lanzillotta, Miriam Sant'Angelo, Naoki Kaneko, Shiv Pillai, Maurilio Ponzoni, Emanuel Della-Torre

TAFRO syndrome (Thrombocytopenia, Anasarca, Fever, Reticulin fibrosis, and Organomegaly) is a newly recognized variant of idiopathic - human herpesvirus-8 (HHV-8) negative - Multicentric Castleman... more

Diagnosis of infection by SARS-COV-2: Is one molecular test enough?

12 February 2021
Author(s): Antonella Mencacci, Maria Cristina Vedovati, Barbara Camilloni, Elio Cenci, Cecilia Becattini

A pandemic phase of SARS-CoV-2 infection is currently ongoing, with a particular diffusion in Italy [1]. Accurate diagnosis of asymptomatic carriers of the virus as well as of patients with acute... more

“Let me choose my COVID-19 vaccine”

3 February 2021
Author(s): Rafael Dal-Ré, Richard Stephens, Nadarajah Sreeharan

In the first half of 2021, many millions of Europeans will be offered vaccination against SARS -CoV-2. Four vaccines, two mRNA-based vaccines (Pfizer-BioNTech and NIH-Moderna) and two non-replicating... more

SARS-CoV-2 seroprevalence in the Vatican City State

3 February 2021
Author(s): Massimo Ralli, Andrea Arcangeli, Paolo Maurizio Soave, Maria Cristina Voglino, Fabio De-Giorgio

The ongoing Coronavirus Disease 19 (COVID-19) pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has affected so far 218 countries with over 94 million cases, about 2... more

How specific are elevated IgG4 levels for IgG4-related disease?

1 February 2021
Author(s): M. Schils, A. Betrains, S. Vanderschueren, X. Bossuyt, D. Blockmans

IgG4-Related Disease (IgG4-RD) is a systemic inflammatory disorder with potential to affect almost every organ [1]. The diagnosis of IgG4-RD is primarily based upon characteristic histological... more

A systematic bias assessment of top-cited full-length original clinical investigations related to COVID-19

22 January 2021
Author(s): Islam Y. Elgendy, Nayef Nimri, Amr F. Barakat, Joseph Ibrahim, John Mandrola, Andrew Foy

With the emergence of coronavirus disease 2019 (COVID-19) pandemic, there has been an exponential rise in the number of scientific publications to convey relevant information about this novel disease... more

Vertebral level identified by the intercristal line: Confirmation by ultrasound

22 January 2021
Author(s): Drew Brotherston, Janeve Desy, Irene W.Y. Ma

Prior to performing a lumbar puncture (LP) at the bedside, the intercristal line, formed posteriorly between the superior aspect of the iliac crests, commonly serves as a landmark to identify the L4... more

Longitudinal trends and outcomes of adult heart transplantation in the U.S.

22 January 2021
Author(s): Emmanuel Akintoye, Rabea Asleh, Paulino Alvarez, Alexandros Briasoulis

Heart transplantation is the treatment of choice for patients with end-stage heart failure [1, 2]. Evaluation of outcome trends is imperative to identifying areas of improvement and making goal-... more

Do four SGLT2 inhibitors lead to different cardiorenal benefits in type 2 diabetes, in chronic heart failure, and in chronic kidney disease?

20 January 2021
Author(s): Mei Qiu, Liang-Liang Ding, Ze-Lin Zhan, Hai-Rong Zhou

Large randomized trials have confirmed the cardiorenal benefits from sodium-glucose transporter 2 (SGLT2) inhibitors for patients with type 2 diabetes (T2D), for patients with chronic heart failure... more

Less is more: Perspectives from the European Code Against Cancer

16 January 2021
Author(s): Christos Tsagkaris, Parvathy Mohanan

We have read the article of Kherad et al. with great interest. The authors elaborate on the “less is more” principle, which has become quite relevant in various areas of medicine including cancer [1... more

Flying higher than politics: The goal of preventive medicine at the time of the COVID-19 pandemic

1 January 2021
Author(s): Francesco M. Galassi, Michael E. Habicht, F. Donald Pate, Elena Varotto

The present SARS-CoV-2-caused COVID-19 pandemic [1] has clearly shown that great health crises can elicit heated political and scientific debates. The history of medicine teaches us how, throughout... more

Heart rate turbulence in obstructive sleep apnea syndrome: The effect of short-term CPAP therapy

31 December 2020
Author(s): Giovanni D'Addio, Alberto De Felice, Leandro Donisi, Alberto Braghiroli, Mauro Maniscalco

Patients affected by obstructive sleep apnea (OSA) present an increased risk of cardiovascular (CV) events [1]. This is likely due to the imbalance in the autonomic nervous system, with cardiac... more

Low influenza vaccination coverage among hospitalized COVID-19 patients in Milan: A gap to be urgently filled

29 December 2020
Author(s): Anna Lisa Ridolfo, Laura Milazzo, Andrea Giacomelli, Letizia Oreni, Catia Borriello, Spinello Antinori

The first wave of the COVID-19 epidemic in Italy during March and April 2020 put extreme pressure on the national healthcare system, particularly on the hospitals in the most affected regions of... more

Original Article

Clinical significance of anti-Ro52 (TRIM21) antibodies in adult patients with connective tissue diseases

7 May 2021
Author(s): Paul Decker, Thomas Moulinet, Benjamin Lopez, Sylvain Dubucquoi, Bernard Bonnotte, Daniela Lakomy, Sabine Revuz, Amandine Luc, Marcelo De Carvalho Bittencourt, Eric Hachulla, Roland Jaussaud

Connective tissue diseases (CTD) – rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Sjögren syndrome (SS), systemic sclerosis (SSc), idiopathic inflammatory myopathies (IIM), mixed... more

Inhaled antibiotics for treatment of adults with non-cystic fibrosis bronchiectasis: A systematic review and meta-analysis

1 May 2021
Author(s): Sofia Tejada, Laura Campogiani, Candela Solé-Lleonart, Aroa Gómez, Miguel Gallego, Monserrat Vendrell, Joan B. Soriano, Jordi Rello

Non-cystic fibrosis bronchiectasis (NCFB) is a chronic, progressive respiratory disease characterized by permanent and abnormal dilation of the bronchial walls, mucociliary dysfunction, mucus... more

Prevalence, determinants and practical implications of inappropriate hospitalizations in older subjects: A prospective observational study

1 May 2021
Author(s): Gianluca Isaia, Enrico Brunetti, Roberto Presta, Bianca Salone, Giulia Carignano, Matteo Sappa, Gianfranco Fonte, Silvio Raspo, Giuseppe Lauria, Franco Riccardini, Enrico Lupia, Mario Bo

Over the last decades, along with the aging of the population, an increase in the demand for medical services has been observed in developed countries. Older people are more prone to illnesses, often... more

Diagnostic accuracy of D-Dimer testing for recurrent venous thromboembolism: A systematic review with meta-analysis.

29 April 2021
Author(s): Matteo Nicola Dario Di Minno, Ilenia Calcaterra, Antimo Papa, Roberta Lupoli, Alessandro Di Minno, Mauro Maniscalco, Pasquale Ambrosino

With an annual incidence of 1-2 per 1,000 individuals, venous thromboembolism (VTE) is the third leading vascular diagnosis after heart attack and stroke [1,2]. VTE encompasses two interrelated... more

Clinical outcomes of biliary drainage of malignant biliary obstruction due to colorectal cancer metastases: A systematic review

27 April 2021
Author(s): Janine B Kastelijn, Maria ATC van der Loos, Paco MJ Welsing, Elisabeth Dhondt, Miriam Koopman, Leon MG Moons, Frank P. Vleggaar

Malignant biliary obstruction is an ominous complication of metastatic colorectal cancer (mCRC) and is associated with a poor prognosis.[1–3] It has been reported to occur in 10% of patients with... more

Serum uric acid and outcomes in patients with chronic heart failure through the whole spectrum of ejection fraction phenotypes: Analysis of the ESC-EORP Heart Failure Long-Term (HF LT) Registry

23 April 2021
Author(s): Giuseppe Ambrosio, Marisa G. Crespo Leiro, Lars H. Lund, Stefano Coiro, Andrea Cardona, Gerasimos Filippatos, Roberto Ferrari, Massimo F. Piepoli, Andrew J.S. Coats, Stefan D. Anker, Cécile Laroche, Luis Almenar-Bonet, Pentti Poder, David Bierge Valero, Anna Frisinghelli, Aldo P. Maggioni

Heart failure (HF) is a heterogeneous clinical syndrome, associated with a spectrum of metabolic disorders. Serum uric acid (sUA), the end-product of purine degradation, has shown prognostic value in... more

Joint effect of heart failure and coronary artery disease on the risk of death during hospitalization for COVID-19

19 April 2021
Author(s): Fabio Angeli, Jacopo Marazzato, Paolo Verdecchia, Antonella Balestrino, Claudio Bruschi, Piero Ceriana, Luca Chiovato, Laura Adelaide Dalla Vecchia, Roberto De Ponti, Francesco Fanfulla, Maria Teresa La Rovere, Francesca Perego, Simonetta Scalvini, Antonio Spanevello, Egidio Traversi, Dina Visca, Michele Vitacca, Tiziana Bachetti

Since the initial coronavirus (SARS-CoV-2) outbreak in the province of Wuhan, China, more than 50 million people have been infected so far, causing unnerving impact on routine patient care and... more

Adrenomedullin as a potential biomarker involved in patients with hereditary hemorrhagic telangiectasia

19 April 2021
Author(s): A. Iriarte, L. Ochoa-Callejero, J. García-Sanmartín, P. Cerdà, P. Garrido, J. Narro-Íñiguez, JM. Mora-Luján, A. Jucglà, MA Sánchez-Corral, F. Cruellas, E. Gamundi, J. Ribas, J. Castellote, F. Viñals, A. Martínez, A. Riera-Mestre

Hereditary hemorrhagic telangiectasia (HHT) or Rendu–Osler–Weber syndrome (ORPHA774) is a rare autosomal dominant vascular disease characterized by telangiectases and larger vascular malformations (... more

Autologous fecal microbiota transplantation can retain the metabolic achievements of dietary interventions

18 April 2021
Author(s): Ehud Rinott, Ilan Youngster, Anat Yaskolka Meir, Gal Tsaban, Alon Kaplan, Hila Zelicha, Elad Rubin, Omry Koren, Iris Shai

We recently reported that autologous fecal microbiota transplantation (aFMT), derived from the time of maximal weight-loss and administrated in the regain-phase, might preserve weight loss and... more

Efficacy and safety of steroid-sparing treatments in giant cell arteritis according to the glucocorticoids tapering regimen: A systematic review and meta-analysis

17 April 2021
Author(s): Anne-Laure Gérard, Noémie Simon-Tillaux, Youri Yordanov, Patrice Cacoub, Florence Tubach, David Saadoun, Agnès Dechartres

Giant cell arteritis (GCA) is the most common systemic vasculitis in Western countries, with an annual incidence of 10 to 20 per 100,000 adults older than 50 years and increasing with age [1]. Its... more

Adiponectin involved in portal flow hepatic extraction of 13C-methacetin in obesity and non-alcoholic fatty liver

15 April 2021
Author(s): Agostino Di Ciaula, Federico Carbone, Harshitha Shanmugham, Emilio Molina-Molina, Leonilde Bonfrate, Stefano Ministrini, Fabrizio Montecucco, Piero Portincasa

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease with a worldwide prevalence of about 30% [1]. NAFLD frequently occurs in overweight and obese individuals [... more

Drug withdrawal in patients with autoimmune hepatitis in long-term histological remission: A prospective observational study

14 April 2021
Author(s): Floris F. van den Brand, Romée J.A.L.M. Snijders, Ynto S. de Boer, Bart J. Verwer, Carin M.J. van Nieuwkerk, Elisabeth Bloemena, Sjoerd D. Kuiken, Joost P.H. Drenth, Gerd Bouma

Recommendations for drug withdrawal in patients with autoimmune hepatitis (AIH) in longstanding remission are conflicting and rely on retrospective data. We prospectively investigated the predictive... more

Post-discharge antithrombotic management and clinical outcomes of patients with new-onset or pre-existing atrial fibrillation and acute coronary syndromes undergoing coronary stenting: Follow-up data of the MATADOR-PCI study

7 April 2021
Author(s): Leonardo De Luca, Andrea Di Lenarda, Andrea Rubboli, Leonardo Bolognese, Lucio Gonzini, Federico Fortuni, Alessandro Navazio, Fabrizio Poletti, Antonietta Ledda, Stefano Urbinati, Domenico Gabrielli, Michele Massimo Gulizia, MATADOR-PCI Investigators

. Patients with concomitant atrial fibrillation (AF) and acute coronary syndromes (ACS) do not seem to receive proper antithrombotic therapies and present high rates of adverse clinical events.

Effect of SGLT-2 inhibitors on cardiovascular outcomes in heart failure patients: A meta-analysis of randomized controlled trials

3 April 2021
Author(s): Yuan Lu, Fei Li, Yong Fan, Yu Yang, Minglong Chen, Jue Xi

Heart failure (HF) is a highly prevalent disease with considerable morbidity and mortality. It is estimated that approximately 50 million people are afflicted with this disease worldwide. The disease... more

Sex-specific differences in the presentation, clinical course, and quality of life of patients with acute venous thromboembolism according to baseline risk factors. Insights from the PREFER in VTE

30 March 2021
Author(s): Michela Giustozzi, Luca Valerio, Giancarlo Agnelli, Cecilia Becattini, Eva-Maria Fronk, Frederikus A. Klok, Stavros V. Konstantinides, Maria Cristina Vedovati, Alexander T. Cohen, Stefano Barco

The presentation and prognosis of venous thromboembolism (VTE) are known to be characterized by considerable sex differences. While men and women have a similar overall risk of developing a first... more

Lessons from pathophysiology: Use of individualized combination treatments with immune interventional agents to tackle severe respiratory failure in patients with COVID-19

26 March 2021
Author(s): George N. Dalekos, Aggelos Stefos, Sarah Georgiadou, Vasiliki Lygoura, Anastasia Michail, George Ntaios, Anna Samakidou, George Giannoulis, Stella Gabeta, Marianna Vlychou, Efthymia Petinaki, Konstantinos Leventogiannis, Evangelos J. Giamarellos-Bourboulis, Nikolaos K. Gatselis

Aims Infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may lead to the development of severe respiratory failure. In hospitalized-patients, prompt interruption of the virus-... more

Growth differentiation factor-15 predicts major adverse cardiac events and all-cause mortality in patients with atrial fibrillation

8 March 2021
Author(s): Stephan Nopp, Oliver Königsbrügge, Daniel Kraemmer, Ingrid Pabinger, Cihan Ay

Atrial fibrillation (AF), the most common cardiac arrhythmia, is associated with high morbidity and mortality, largely attributable to an increased risk of stroke and systemic embolism.... more

TGF-β1 +869T/C (rs1982073) gene polymorphism and susceptibility to rheumatoid arthritis: Updated systematic review and meta-analysis

22 February 2021
Author(s): Haiyan Zeng, Wuniu Wan, Jin Li, Chengsong He

Rheumatoid arthritis (RA) is a complex autoimmune disease that affects about 1% of the world's population, which is characterized by the erosion and destruction of cartilage and bone [1,2]. As a... more

Incidence and risk factors for preneoplastic and neoplastic lesions of the colon and rectum in patients under 50 referred for colonoscopy

17 February 2021
Author(s): Simona Agazzi, Marco Vincenzo Lenti, Catherine Klersy, Elena Strada, Lodovica Pozzi, Laura Rovedatti, Marco Bardone, Aurelio Mauro, Martina Costetti, Stefania Costa, Federico De Grazia, Antonio Di Sabatino

According to estimates from the International Agency for Research on Cancer (2018), colorectal cancer (CRC) occurred in approximately 1.8 million patients and accounted for 900000 deaths worldwide,... more

Myocardial infarction during giant cell arteritis: A cohort study

17 February 2021
Author(s): Hélène Greigert, Marianne Zeller, Alain Putot, Eric Steinmetz, Béatrice Terriat, Maud Maza, Nicolas Falvo, Géraldine Muller, Louis Arnould, Catherine Creuzot-Garcher, André Ramon, Laurent Martin, Georges Tarris, Tibor Ponnelle, Sylvain Audia, Bernard Bonnotte, Yves Cottin, Maxime Samson

Giant cell arteritis (GCA) is the most frequent vasculitis in adults over 50 years. It is a granulomatous large-vessel vasculitis mainly involving the aorta and cranial arteries [1–3]. Clinical signs... more

Non–Specific Clinical Presentations are Not Prognostic and do not Anticipate Hospital Length of Stay or Resource Utilization

16 February 2021
Author(s): Richard Conway, Declan Byrne, Deirdre O'Riordan, Bernard Silke

Up to 20% of patients arriving at an emergency department (ED) may have a non-specific presentation (NSP). Previous studies have suggested that a NSP, despite the similarity of patient demographics... more

Prediction and primary prevention of major vascular complications in systemic sclerosis

5 February 2021
Author(s): Cosimo Bruni, Laura Cometi, Antonietta Gigante, Edoardo Rosato, Marco Matucci-Cerinic

Systemic Sclerosis (SSc) is a chronic autoimmune disease, characterized by immune system activation, vascular abnormalities and uncontrolled fibrotic response in the skin and internal organs [1]. The... more

Venous lactate improves the prediction of in-hospital adverse outcomes in normotensive pulmonary embolism

5 February 2021
Author(s): Matthias Ebner, Charlotta F. Pagel, Carmen Sentler, Veli-Pekka Harjola, Héctor Bueno, Markus H. Lerchbaumer, Karl Stangl, Burkert Pieske, Gerd Hasenfuß, Stavros V. Konstantinides, Mareike Lankeit

Pulmonary embolism (PE) is associated with high morbidity and mortality, making it a major contributor to global disease burden. [1,2] Thus, current guideline recommendations emphasize the importance... more

Patient motivation to lose weight: Importance of healthcare professional support, goals and self-efficacy

5 February 2021
Author(s): Dror Dicker, Assim A. Alfadda, Walmir Coutinho, Ada Cuevas, Jason C.G. Halford, Carly A. Hughes, Masato Iwabu, Jae-Heon Kang, Rita Nawar, Ricardo Reynoso, Nicolai Rhee, Georgia Rigas, Javier Salvador, Paolo Sbraccia, Verónica Vázquez-Velázquez, Ian D. Caterson

Obesity is a global health concern [1]. Multiple complications are associated with overweight and obesity including diabetes, heart disease, musculoskeletal disorders and some cancers, and people... more

Long-term effectiveness and safety of anticoagulation therapy in oldest old, frail people with atrial fibrillation

4 February 2021
Author(s): Valeria Calsolaro, Chukwuma Okoye, Rachele Antognoli, Umberto Dell'Agnello, Alessia Maria Calabrese, Fabio Monzani

Atrial fibrillation (AF) is the most common cardiac arrhythmia in clinical practice [1] with a prevalence destined to progressively increase due to population aging [2]. As a fact, AF represents a... more

Anakinra for patients with COVID-19: a meta-analysis of non-randomized cohort studies.

4 February 2021
Author(s): Laura Pasin, Giulio Cavalli, Paolo Navalesi, Nicolò Sella, Giovanni Landoni, Andrey G. Yavorovskiy, Valery V. Likhvantsev, Alberto Zangrillo, Lorenzo Dagna, Giacomo Monti

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affected 104.956.439 people worldwide and caused the death of 2.290.488 as of February 7, 2121[1]. Life-threatening cases of the... more

Assessing the impact of COVID-19 on the health of geriatric patients: The European GeroCovid Observational Study

30 January 2021
Author(s): Caterina Trevisan, Susanna Del Signore, Stefano Fumagalli, Pietro Gareri, Alba Malara, Enrico Mossello, Stefano Volpato, Fabio Monzani, Alessandra Coin, Giuseppe Bellelli, Gianluca Zia, Anette Hylen Ranhoff, Raffaele Antonelli Incalzi, the GeroCovid Working Group

Older adults have been the part of the population most burdened by COVID-19 pandemic. Indeed, the disease mortality rate was reported to rise, in men and women, from 4.6% and 2.5% among those aged 30... more

Age-Related Changes in Clinical Presentation of Covid-19: the EPICOVID19 Web-Based Survey

29 January 2021
Author(s): Caterina Trevisan, Marianna Noale, Federica Prinelli, Stefania Maggi, Aleksandra Sojic, Mauro Di Bari, Sabrina Molinaro, Luca Bastiani, Andrea Giacomelli, Massimo Galli, Fulvio Adorni, Raffaele Antonelli Incalzi, Claudio Pedone, on behalf of the EPICOVID19 Working Group

The burden posed by the Covid-19 pandemic on healthcare systems requires strategies to identify high-risk people in order to better allocate the available health resources and plan targeted care... more

Impact of the number of comorbidities on cardiac sympathetic derangement in patients with reduced ejection fraction heart failure

20 January 2021
Author(s): Leonardo Bencivenga, Klara Komici, Grazia Daniela Femminella, Stefania Paolillo, Paola Gargiulo, Roberto Formisano, Roberta Assante, Carmela Nappi, Brunella Puzone, Immacolata Sepe, Antonio Cittadini, Dino Franco Vitale, Nicola Ferrara, Alberto Cuocolo, Pasquale Perrone Filardi, Giuseppe Rengo

Heart failure (HF) is a very prevalent condition associated with high morbidity and mortality rates, thus representing a relevant global health burden. It affects more than 26 million people... more

Cannabis is associated with blood pressure reduction in older adults – A 24-hours ambulatory blood pressure monitoring study

20 January 2021
Author(s): Ran Abuhasira, Yosef S. Haviv, Merav Leiba, Adi Leiba, Larisa Ryvo, Victor Novack

Background: Medical cannabis use is increasing rapidly in the past several years, with older adults being the fastest growing group. Nevertheless, the evidence for cardiovascular safety of cannabis... more

Non-retrieved inferior vena cava filters: causes and long-term follow-up

6 January 2021
Author(s): Jesús Ribas, Esther Alba, Yuliana Pascual-González, Yolanda Ruíz, Adriana Iriarte, José María Mora-Luján, Joana Valcárcel, Xavier Corbella, Salud Santos, Elena Escalante, Antoni Riera-Mestre

Inferior vena cava (IVC) filters are implantable devices created to trap thrombi from the lower extremities and prevent clinically significant pulmonary embolism (PE). According to guidelines, the... more

Predictors of mortality among adult, old and the oldest old patients with bloodstream infections: An age comparison

4 January 2021
Author(s): Francesca Giovannenze, Rita Murri, Claudia Palazzolo, Francesco Taccari, Marta Camici, Teresa Spanu, Brunella Posteraro, Maurizio Sanguinetti, Roberto Cauda, Graziano Onder, Massimo Fantoni

In recent years, incidence of bloodstream infections (BSIs) has been increasing worldwide, with over 1.2 million estimated episodes of BSI per year in Europe and around 600 000 in North America [1].... more

Neuraminidase inhibitors are effective and safe in reducing influenza complications: meta-analysis of randomized controlled trials.

21 December 2020
Author(s): Sofía Tejada, Miia Jansson, Candela Solé-Lleonart, Jordi Rello

Influenza is an infection of variable severity resulting in high accumulated mortality worldwide [1]. Seasonal influenza deaths occur mainly in young children and the elderly, while during influenza... more

Is there excessive troponin testing in clinical practice? Evidence from emergency medical admissions

19 December 2020
Author(s): Richard Conway, Declan Byrne, Seán Cournane, Deirdre O'Riordan, Seamus Coveney, Bernard Silke

Troponin assays are a relatively common laboratory diagnostic request in emergency medical admissions. Following cardiac injury these macromolecules diffuse into the cardiac interstitium with... more

Review Article

The use of β-blockers in patients with heart failure and comorbidities: Doubts, certainties and unsolved issues

30 April 2021
Author(s): Stefania Paolillo, Simona Dell'Aversana, Immacolata Esposito, Alessandra Poccia, Pasquale Perrone Filardi

β-blockers represent a mainstay in the pharmacological approach to patients affected by heart failure with reduced ejection fraction (HFrEF). However, underuse of this class of drugs is still... more

SARS-CoV-2 vaccines: Lights and shadows

29 April 2021
Author(s): Fabio Angeli, Antonio Spanevello, Gianpaolo Reboldi, Dina Visca, Paolo Verdecchia

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread across the world and killed more than 2.9 million individuals globally, with 137 million cases being confirmed by... more

Rabies in Europe: An epidemiological and clinical update

29 April 2021
Author(s): Niccolò Riccardi, Andrea Giacomelli, Roberta Maria Antonello, Federico Gobbi, Andrea Angheben

Rabies is a vaccine preventable zoonosis with a significant mortality burden worldwide, causing about 60,000 deaths each year [1]. Nevertheless, rabies is still a neglected disease [2]. Rabies is... more

Obesity as an adipose tissue dysfunction disease and a risk factor for infections – Covid-19 as a case study

2 April 2021
Author(s): MF Landecho, M Marin-Oto, B Recalde-Zamacona, I Bilbao, Gema Frühbeck

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV2) disease (COVID-19) is a novel threat that hampers life expectancy especially in obese individuals. Though this association is clinically... more

Non-invasive respiratory support in the treatment of acute hypoxemic respiratory failure secondary to CoViD-19 related pneumonia

25 February 2021
Author(s): Paolo Groff, Rodolfo Ferrari

While many of the epidemiological aspects and clinical characteristics of CoViD-19 disease have been understood [1-3], little has been clarified regarding the best ventilatory support to offer to... more

Sustainable and personalized nutrition: From earth health to public health

25 February 2021
Author(s): C. Agostoni, S Boccia, S Banni, P.M. Mannucci, A Astrup

In the difficult times amidst the SARS-CoV-2 pandemic, the whole world has become more conscious of the importance of primary and secondary prevention. COVID-19 is already having a triple hit on... more

Multidisciplinary prevention and management strategies for colorectal cancer and cardiovascular disease

17 February 2021
Author(s): Seamus P. Whelton, Philipp Berning, Roger S. Blumenthal, Catherine Handy Marshall, Seth S. Martin, Martin Bødtker Mortensen, Michael J. Blaha, Omar Dzaye

Colorectal cancer (CRC) and Cardiovascular disease (CVD) represent leading causes of morbidity and mortality in industrialized countries [1]. While they are typically thought of as separate disease... more

Sweet taste and obesity

13 February 2021
Author(s): Gabriela Ribeiro, Albino J. Oliveira-Maia

Obesity is associated with significant morbidity and mortality, and currently represents a global health challenge[1]. While it is associated with complex pathophysiology, increased availability of... more

Beyond the 2020 guidelines on atrial fibrillation of the European society of cardiology

28 January 2021
Author(s): Giuseppe Boriani, Marco Vitolo, Deirdre A Lane, Tatjana S Potpara, Gregory YH Lip

The history of guidelines began in 1990 when the Institute of Medicine (IOM) published a report defining guidelines as "systematically developed statements to assist practitioner and patient... more

Mechanisms of weight regain.

16 January 2021
Author(s): Luca Busetto, Silvia Bettini, Janine Makaronidis, Carl A. Roberts, Jason C.G. Halford, Rachel L. Batterham

Obesity is a chronic progressive disease with a high tendency to recidivism. Weight regain is frequent after any attempts of voluntary weight loss [1]. Weight regain is frequently attributed to the... more


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