Atrial fibrillation (AF) is the most common cardiac arrhythmia in clinical practice [1] with a prevalence destined to progressively increase due to population aging [2]. As a fact, AF represents a major cause of morbidity and mortality [3,4] in older people [5–8], and the only condition independently related to stroke occurrence in octogenarians [6]. Interestingly, Fumagalli et al recently found a correlation between inflammatory mediators levels and higher values of CHA2DS2-VASc, which was, in turn, correlated with physical performance and frailty, suggesting that inflammation may play a role in the association between frailty and thromboembolic risk [9].
