While many of the epidemiological aspects and clinical characteristics of CoViD-19 disease have been understood [1-3], little has been clarified regarding the best ventilatory support to offer to affected patients. Most of the available studies are the result of monocentric experiences and are retrospective. As a consequence, many indications derive from theoretical assumptions and there is a substantial uncertainty regarding the timing, the definite indications, the duration, the success/ failure criteria of the methods.