Published: 17 February 2022
Author(s): Alessandro Mengozzi, Agostino Virdis
Issue: May 2022
Section: Commentary

Uric acid (UA) is the end product of purine metabolism. Whilst being primarily known as the leading risk factor for the onset of gout [1], UA has also been acknowledged as a significant CV risk factor [2]. However, international guidelines report as pathological threshold only the saturation point of UA (6.0 mg/dL in women and ≥7.0 mg/dL in men) [3], yet failing to identify a specific CV prevention cut-off [4]. This somewhat neglects UA predictive role in CV disease [5]. In a large (n=22,714) Italian-population based observation cohort study, we have described how UA markedly impact all-cause and CV mortality starting from lower serum levels (respectively, 4.7 and 5.6 mg/dL) [2].


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