Published: 22 April 2024
Author(s): Piero Portincasa, Gyorgy Baffy
Issue: May 2024
Section: Clinical Insights

The liver is affected by metabolic dysfunction, featuring variable degrees of steatosis, inflammation, liver cell injury, and fibrosis. Since alcohol can cause similar changes in the liver, this condition was named “nonalcoholic steatohepatitis” (NASH) in 1980 [1], followed by the more encompassing term of “nonalcoholic fatty liver disease” (NAFLD) in 1986 [2]. NAFLD represents a disease spectrum ranging from steatosis to steatohepatitis with potential progression to cirrhosis and hepatocellular carcinoma [3,4].

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