Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune disease with a protean clinical phenotype ranging from very mild manifestations of dry eye and dry mouth to life-threatening major organ involvement and damage [1]. It mostly affects females with a female:male ratio of 9–20:1 and can present as a single disease or associated to other autoimmune conditions, such as rheumatoid arthritis and systemic lupus erythematosus [2,3]. Despite the course of pSS is generally indolent and usually not requiring systemic immunosuppressive therapies, even mild forms of the disease almost inevitably detrimentally affect patients’ quality of life [4].
