Common to several allergic diseases is the generation of immunoglobulin E (IgE) by plasma cells, when exposed to an innocuous antigen [1]. Upon initial exposure to allergen, antigen presenting cells capture, process and present allergen peptides to T-cells, which are transformed to the Th2-phenotype, proliferate and engage B-cells to differentiate into plasma cells, which produce IgEs [2]. IgEs bind almost irreversibly to the high affinity IgE receptor (FcεRI) on the surface of mast cells or basophils to create “allergen receptors” [1,2].
