Published: 28 March 2025
Author(s): Xie He, Shunhong Chen, Ruiting Huang
Issue: May 2025
Section: Internal Medicine Flashcard

A 35-year-old man presented with multiple brown macules on the limbs without associated pruritus or pain for 2 years. He observed these changes with no identifiable triggers, and noted a gradual increase and expansion of the lesions over time. Physical examination revealed multiple brown macules on the forearms, calves and insteps (Fig. 1A, B). Histopathological examination revealed epidermal hyperkeratosis, mild perivascular lymphocytic infiltrates in the dermis, and scattered hemosiderin deposits (Fig.

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