Autoinflammatory disorders represent a heterogenous group of genetic or acquired systemic diseases characterized by febrile episodes and chronic inflammation, due to dysregulation of innate immunity, in the absence of autoantibodies or antigen-specific T cells [1]. Among them, Familial Mediterranean fever (FMF), is the most common autosomal recessive autoinflammatory syndrome, affecting >100,000 people worldwide and being particularly prevalent in eastern Mediterranean countries among Arabs, Turks, Armenians and non-Ashkenazi Jews [2].
