The recent report on “risk of coronary artery disease in transfusion-naïve thalassemia populations [1]” is very interesting. In fact, thalassemia is a common congenital inherited hemoglobin disorder that is common in several parts of the world. Anemia is a common finding. As noted by Chen et al., increase risk of heart disease can be seen in case with thalassemia [1]. Additional concern should be mentioned in thalassemic case that already gets the acute coronary syndrome. Anemia in acute coronary syndrome needs comprehensive care.