Published: 6 November 2017
Author(s): Lynnda J.N. van Tienhoven-Wind, Eke G. Gruppen, Wim J. Sluiter, Stephan J.L. Bakker, Robin P.F. Dullaart
Section: Letter to the Editor

During the past few years the concept is emerging that differences in thyroid function status even within the reference range may impact on a wide number of health issues [1,2]. Low-normal thyroid function, as reflected by higher thyroid stimulating hormone (TSH) and/or lower free thyroxine (FT4) or free triiodothyronine (FT3) levels within the euthyroid reference range, associate with enhanced atherosclerosis susceptibility [2]. A high-normal TSH level within the reference range was associated with mortality from cardiovascular diseases (CVD) in a single cohort study, but such a relationship was not found in a recent meta-analysis [3].

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