November 2017

15 Articles


Introduction to the special issue on acutely ill patients

8 November 2017
Author(s): John Kellett, Radovan Hojs

As medicine becomes more successful the demand for acute care can only increase. Before modern intensive care many patients died during their first major medical emergency. Nowadays, even for... more

Invited Article

Biological treatments in giant cell arteritis & Takayasu arteritis

13 November 2017
Author(s): Maxime Samson, Georgina Espígol-Frigolé, Nekane Terrades-García, Sergio Prieto-González, Marc Corbera-Bellalta, Roser Alba-Rovira, José Hernández-Rodríguez, Sylvain Audia, Bernard Bonnotte, Maria C. Cid

Giant cell arteritis (GCA) and Takayasu arteritis (TAK) are the two main large vessel vasculitides. They share some similarities regarding their clinical, radiological and histological presentations... more

Letter to the Editor

On the use of substandard medicines in hematology: An emerging concern in the Middle East and North Africa region

24 November 2017
Author(s): Mervat Mattar, Collaborators of the NEtwork for Drug Quality and Safety (NEDQAS)

Generic drugs (generics) are vital to the sustainability of health care systems, especially in developing areas with low resources. Ensuring benefit to patients through the approval and delivery of... more

CISNE or MASCC, which predictor is really the weakest in febrile neutropenia?

20 November 2017
Author(s): A. Carmona-Bayonas, P. Jiménez-Fonseca

Daniel Kahneman convincingly disputes that heuristic shortcuts produce cognitive biases; large doses of patience and reflection are needed to counteract them [1], although sometimes this is... more

Prevalence of bendopnea in general population without heart failure

20 November 2017
Author(s): Ramón Baeza-Trinidad, Oscar Isaula-Jimenez, Carmen Peinado-Adiego, Jose Daniel Mosquera-Lozano

Recently, a new symptom of heart failure called bendopnea and its prognosis was described [1–4]. We called bendopnea to the lack of air that occurs during the first 30s while bending forward. The... more

Periods of unexplained higher deaths and medical admissions have occurred previously – But have apparently been ignored, misinterpreted or not investigated

16 November 2017
Author(s): Rodney P. Jones

I have recently published three studies regarding unexplained periods of higher death and medical admissions [1–3].

The “true clinicians” do not need formal tools to define the complexity of their patients. Is this statement always true?

7 November 2017
Author(s): Roberto Nardi, Micaela La Regina, Andrea Fontanella

In the daily clinical practice, doctors often use their experienced “gut feeling” and/or “spot eye” in the assessment of their complex patients. According to this point of view someone could affirm... more

Life expectancy is unaffected by thyroid function parameters in euthyroid subjects: The PREVEND cohort study

6 November 2017
Author(s): Lynnda J.N. van Tienhoven-Wind, Eke G. Gruppen, Wim J. Sluiter, Stephan J.L. Bakker, Robin P.F. Dullaart

During the past few years the concept is emerging that differences in thyroid function status even within the reference range may impact on a wide number of health issues [1,2]. Low-normal thyroid... more

Helicobacter pylori and proton pump inhibitor therapy: One diagnostic method is enough?

4 November 2017
Author(s): Davide Giuseppe Ribaldone, Giorgio Maria Saracco, Rinaldo Pellicano

In a recent study Negovan et al. assessed the impact of pathological and clinical predisposing factors (histological findings, concomitant drug consumption, comorbidities, symptoms, social habits,... more

Bleeding related to non-vitamin K antagonist oral anticoagulants in emergency department: A “Real-world” snapshot from Southern Italy. On behalf of MIRC-NOAC study group

1 November 2017
Author(s): Andrea Salzano, Marco Proietti, Roberta D'Assante, Lavinia Saldamarco, Antonio Cittadini, Fiorella Paladino

The introduction of non-vitamin K antagonist oral anticoagulants (NOAC) in antithrombotic therapy is one of the major recent milestones in the general pharmacopeia [1]. Despite several papers about... more

Original Article

Treatment with levothyroxin in subclinical hypothyroidism is associated with increased mortality in the elderly

22 November 2017
Author(s): Alon Grossman, Ilan Feldhamer, Joseph Meyerovitch

It is uncertain whether subclinical hypothyroidism should be treated with levothyroxine, particularly in the elderly. This study evaluated the association between levothyroxine treatment and... more

Development and validation of a scoring system for the identification of pleural exudates of cardiac origin

20 November 2017
Author(s): José M. Porcel, Lucia Ferreiro, Carme Civit, Luis Valdés, Aureli Esquerda, Richard W. Light, Silvia Bielsa

Light's criteria misclassify about 30% of cardiac effusions as exudates, possibly leading to unnecessary testing. Our purpose was to derive and validate a scoring model to effectively identify these... more

Prevalence of anemia in hospitalized internal medicine patients: Correlations with comorbidities and length of hospital stay

16 November 2017
Author(s): Carlo Zaninetti, Catherine Klersy, Concetta Scavariello, Raffaella Bastia, Carlo L. Balduini, Rosangela Invernizzi

Several studies have documented a linear growth of the prevalence of anemia with aging. Especially in hospitalized elderly patients, anemia can aggravate the course of chronic disorders, and... more

The cholesterol-lowering effect of statins is potentiated by whole grains intake. The Polish Norwegian Study (PONS)

11 November 2017
Author(s): Georgeta D. Vaidean, Marta Manczuk, Sandeep S. Vansal, Jacqueline Griffith

Hypercholesterolemia treatment guidelines emphasize an adequate whole grains (WG) intake, alone or complementary to pharmacological treatment. We conducted this study to compare the prevalence of... more

The effects of protein intake on albuminuria in different estimated glomerular filtration rate: A population-based study

6 November 2017
Author(s): Yan Liu, Rong-shao Tan, Dao-yuan Zhou, Xiao Xiao, Jian-min Ran, Dan-ping Qin, Xiao-shi Zhong, Jian-guang Hu, Yun Liu, Yuan-yuan Zheng

Chronic kidney disease (CKD) is a serious condition associated with early mortality, decreased quality of life, and increased health-care expenditures.


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