In a recent study Negovan et al. assessed the impact of pathological and clinical predisposing factors (histological findings, concomitant drug consumption, comorbidities, symptoms, social habits, Helicobacter pylori—H. pylori infection) on severe gastro-duodenal lesions in patients on long-term low-dose aspirin and proton pump inhibitors (PPI) treatment [1]. They enrolled patients with chronic low-dose aspirin and PPI therapy referred for an upper digestive endoscopy between September 2012 and December 2015.
