H63/H63D genotype and the H63D allele are associated in patients with hyperferritinemia to the development of metabolic syndrome

The metabolic syndrome (MtS) is present in the 25% of the population of Western countries [1]. MtS is frequently associated with hyperferritinemia (HF) and this can be produced by mutations in the HFE gene [2,3]. Mutations in the HFE gene, such as H63D / H63D, can be associated with MtS [2].