The SAPHO syndrome (Synovitis, Acne, Pustulose, Hyperostosis, Osteitis) described in 1987 associates joint, skin and especially bone damage. It is a rare disease, included in the group of spondyloarthritis. Thrombosis in SAPHO syndrome is rare, there are a few cases reported in the literature. We report here the case of subclavian and brachiocephalic thrombosis in contact with clavicular hyperostosis and active osteitis, followed by a literature review.