Published: 10 July 2020
Author(s): Bertrand Mathon, Alexandre Le Joncour, Franck Bielle, Karima Mokhtari, Anne-Laure Boch, Matthieu Peyre, Zahir Amoura, Patrice Cacoub, Nadia Younan, Sophie Demeret, Eimad Shotar, Sonia Burrel, Arnaud Fekkar, Jérôme Robert, Aymeric Amelot, Marc Pineton de Chambrun, the PSL BRAIN-BIOPSY STUDY GROUP
Section: Original article

The contribution of brain biopsy is well-established for patients with suspected neoplastic lesions, for which its diagnostic yield approaches 95% [1,2]. For nonneoplastic neurological diseases, no recommendation exists regarding the place or appropriate timing of brain biopsy. Limited data support using brain biopsy to determine a diagnosis in human immunodeficiency virus (HIV)-positive patients with neurological symptoms [3,4], cerebral angiitis [5], Creutzfeldt–Jakob disease [6] or dementia [7].

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