November 2020

28 Articles

No Section

Hyperuricaemia and gout in cardiovascular, metabolic and kidney disease

29 July 2020
Author(s): Claudio Borghi, Enrico Agabiti-Rosei, Richard J. Johnson, Jan T. Kielstein, Empar Lurbe, Giuseppe Mancia, Josep Redon, Austin G. Stack, Konstantinos P. Tsioufis

Hyperuricaemia refers to an abnormally high concentration of uric acid in serum [1], typically defined as >7 mg/dL (416 μmol/L) in men and >6 mg/dL in women [2]. Mean serum uric acid has... more

Influence of BMI and geographical region on prescription of oral anticoagulants in newly diagnosed atrial fibrillation: The GLORIA-AF Registry Program

14 May 2020
Author(s): Giuseppe Boriani, Menno V. Huisman, Christine Teutsch, Sabrina Marler, Lionel Riou França, Shihai Lu, Gregory Y.H. Lip, GLORIA-AF Investigators

Body mass index (BMI) is widely used for estimating adiposity and has been extensively studied across different populations for evaluating the relationships between BMI values and the risks of... more


Performance of creatinine- and cystatin C-based formulas to estimate glomerular filtration rate

13 August 2020
Author(s): Giorgio Gentile, Fabio Angeli, Gianpaolo Reboldi

Chronic kidney disease (CKD) affects 8-16% of the population worldwide and is a huge global health issue, given its strong association with higher cardiovascular morbidity and mortality, progression... more

Increased risk of cardiac arrhythmias with cannabis use – More studies are needed

6 August 2020
Author(s): Ran Abuhasira, Victor Novack

The regulations of medical and recreational cannabis are constantly changing in recent years, both in United States and in many other countries around the world [1]. As a consequence of the changing... more


Early diagnosis of idiopathic pulmonary fibrosis: Closer to the goal?

23 August 2020
Author(s): Alessia Comes, Giacomo Sgalla, Luca Richeldi

Early diagnosis of idiopathic pulmonary fibrosis (IPF) is definitely a challenge. Several studies have been investigating how to achieve this goal. IPF is the most common type of idiopathic... more

Internal Medicine Flashcard

Anterior neck mass that appeared after a common cold

1 September 2020
Author(s): Hiroaki Nakagawa, Yasushi Miyata

A 62-year-old man experienced a common cold for 7 days. He presented to the clinic with a 2-day history of anterior neck pain and swelling. His body temperature was 37.4°C, and a soft, well-defined... more

Letter to Editor

Linking hydroxychloroquine to hemolysis in a ‘suspected’ glucose-6-phosphate dehydrogenase deficient patient with COVID-19 infection – a critical appraisal

8 July 2020
Author(s): T.P. Afra, Ram Vasudevan Nampoothiri, Muhammed Razmi T, N. A. Bishurul Hafi

We read the recent letter by De Franceschi et al. [1] attributing acute intravascular hemolysis in a patient with COVID-19 infection to intake of hydroxychloroquine (HCQ). We would like to highlight... more

Letter to the Editor

Glucose-6-phosphate dehydrogenase deficiency associated hemolysis in COVID-19 patients treated with hydroxychloroquine/chloroquine: New case reports coming out

13 August 2020
Author(s): Lucia De Franceschi, Enrico Costa, Francesco Dima, Matteo Morandi, Oliviero Olivieri

Afra TP et al comment our recent report entitled: “acute hemolysis by hydroxychloroquine (HCQ) was observed in G6PD-deficient patient with severe COVID-19 related lung injury” [1,2]. Afra et al.... more

Serum albumin and cardiovascular disease: Does low serum albumin contribute to the emergence and worsening of some cardiovascular diseases?

27 July 2020
Author(s): Stephane Arques

Cardiovascular disease is the leading cause of death worldwide, and the identification of modifiable risk factors potentially implicated in the onset and progression of cardiovascular disease... more

The rise of rules: Will the new EU regulation of medical devices make us safer?

20 July 2020
Author(s): R. Tarricone, O. Ciani, S. D'Acunto, S. Scalzo

Whenever markets fail and minimum level of quality must be guaranteed to consumers, users and the system as a whole, regulations are needed. This is undoubtedly the case for healthcare technologies,... more

Hourly variation in urine (Na+K) in chronic hyponatremia related to SIADH: Clinical implication

16 July 2020
Author(s): G. Decaux, Wim Musch, Fabrice Gankam Kengne, Frédéric Vandergheynst, Bruno Couturier

Dilute urine may be considered to have an isotonic portion and an electrolyte-free water portion. The proportions of electrolytes-free water and isotonic can be measured by the ratio of effective... more

Safety and efficacy of levosimendan in patients with cardiac amyloidosis

3 July 2020
Author(s): Alberto Aimo, Claudio Rapezzi, Chiara Arzilli, Giuseppe Vergaro, Michele Emdin

Amyloidosis is a systemic disease characterized by extracellular deposition of insoluble fibrils [1]. Cardiac amyloidosis (CA) is common in both immunoglobulin light-chain (AL) and transthyretin... more

First comes the A, then the B: what we learned from the COVID-19 outbreak

28 June 2020
Author(s): Roberto Copetti, Giulia Amore, Carmine Cristiano Di Gioia, Daniele Orso

The SARS-CoV-2 epidemic, which has spread to many countries around the world, has hit Europe particularly hard. From our point of view, in a rural emergency department (with an annual patient census... more

Very low reporting rate of connective tissue diseases among coronavirus disease 2019 (Covid-19) patients and the renin-angiotensin system – An overlooked association?

12 June 2020
Author(s): Alessandro Giollo, Giovanni Cioffi, Maurizio Rossini, Ombretta Viapiana, Giovanni De Simone

Severe cases of Covid-19 are strongly associated with pre-existing comorbidities, specifically cardiovascular disease (CVD), diabetes, obesity and hypertension [1]. These conditions are commonly... more

Original Article

Neurological diseases of unknown etiology: Brain-biopsy diagnostic yields and safety

10 July 2020
Author(s): Bertrand Mathon, Alexandre Le Joncour, Franck Bielle, Karima Mokhtari, Anne-Laure Boch, Matthieu Peyre, Zahir Amoura, Patrice Cacoub, Nadia Younan, Sophie Demeret, Eimad Shotar, Sonia Burrel, Arnaud Fekkar, Jérôme Robert, Aymeric Amelot, Marc Pineton de Chambrun, the PSL BRAIN-BIOPSY STUDY GROUP

The contribution of brain biopsy is well-established for patients with suspected neoplastic lesions, for which its diagnostic yield approaches 95% [1,2]. For nonneoplastic neurological diseases, no... more

Quality of care after AKI development in the hospital: Consensus from the 22nd Acute Disease Quality Initiative (ADQI) conference

30 June 2020
Author(s): Etienne Macedo, Azra Bihorac, Edward D. Siew, Paul M. Palevsky, John A. Kellum, Claudio Ronco, Ravindra L. Mehta, Mitchell H. Rosner, Michael Haase, Kianoush B. Kashani, Erin F. Barreto

The short- and long-term consequences of acute kidney injury (AKI) are well-recognized [1–3]. The number of AKI episodes, their severity, and duration are critical determinants of adverse outcomes,... more

VAV3 rs7528153 and VAV3-AS1 rs1185222 polymorphisms are associated with an increased risk of developing hypertension

12 June 2020
Author(s): José Pablo Miramontes-González, Ricardo Usategui-Martín, Javier Martín-Vallejo, Michael Ziegler, Leopoldo López de Isla, Daniel O`Connor, Rogelio González-Sarmiento

Cardiovascular diseases are responsible for around 17 million deaths per year, accounting for nearly one-third of the total deaths in the world. The secondary effects of hypertension account for 9.4... more

Cluster analysis based clinical profiling of Idiopathic Pulmonary Fibrosis patients according to comorbidities evident prior to diagnosis: a single-center observational study

9 June 2020
Author(s): Keren Marks-Garber, Tali Bdolah-Abram, Samir Nusair

Idiopathic Pulmonary Fibrosis (IPF), a progressively destructive lung disease caused by unchecked fibroblast activity and uncontrolled formation of pulmonary scar tissue,[1] has a median survival... more

Comparison of bias and accuracy using cystatin C and creatinine in CKD-EPI equations for GFR estimation

8 June 2020
Author(s): Lu-Xi Zou, Ling Sun, Susanne B. Nicholas, Yan Lu, Satyesh Sinha K, Ruixue Hua

Glomerular filtrate rate (GFR) is the most useful index of kidney function. Reduction of GFR may indicate chronic kidney disease (CKD) or acute kidney injury (AKI) [1]. CKD is a growing global health... more

Anticoagulation resumption after intracranial hemorrhage in patients treated with VKA and DOACs

7 June 2020
Author(s): Daniela Poli, Emilia Antonucci, Elisa Vignini, Lucia Martinese, Sophie Testa, Paolo Simioni, Vittorio Pengo, Pasquale Pignatelli, Anna Falanga, Lucilla Masciocco, Doris Barcellona, Antonio Ciampa, Paolo Chiarugi, Carmelo Paparo, Walter Ageno, Gualtiero Palareti, START2 Registry investigators

Intracranial hemorrhage (ICH) is associated with high mortality and severe functional outcome [1]. ICH is frequently associated to antithrombotic treatment and carries a substantial risk of... more

The effect of Mid-Day Sleep on blood pressure levels in patients with arterial hypertension

29 May 2020
Author(s): Manolis S Kallistratos, Leonidas E Poulimenos, Pavlos Tsinivizov, Dimitris Varvarousis, Nikolaos Kouremenos, Andreas Pittaras, Andreas S Triantafyllis, Athanasios J Manolis

Life style changes represent the cornerstone of treatment in patients with arterial hypertension since not only they decrease blood pressure (BP) levels, but also reduce cardiovascular (CV) risk [1... more

Safety and Tolerability of Neurohormonal Antagonism in Cardiac Amyloidosis

28 May 2020
Author(s): Alberto Aimo, Giuseppe Vergaro, Vincenzo Castiglione, Claudio Rapezzi, Michele Emdin

Amyloidosis is a systemic disease characterized by extracellular deposition of insoluble fibrils, deriving from proteins encoded by mutated genes or normal, misfolded proteins [1,2]. Previously... more

Prevalence and risk factors for pulmonary embolism in patients with suspected acute exacerbation of COPD: a multi-center study.

28 May 2020
Author(s): Francesco Dentali, Fulvio Pomero, Pierpaolo Di Micco, Micaela La Regina, Federica Landini, Nicola Mumoli, Filippo Pieralli, Matteo Giorgi-Pierfranceschi, Roberta Re, Josè Vitale, Leonardo M Fabbri, Andrea Fontanella, Dimitriy Arioli, for the Young-FADOI Study Group

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide [1]. Acute exacerbation of COPD is a frequent cause of admission to an emergency department and of... more

Use of intravenous iron in patients with iron deficiency and chronic heart failure: Real-world evidence

19 May 2020
Author(s): José Gonzalez-Costello, Miguel Cainzos-Achirica, Josep Lupón, Nuria Farré, Pedro Moliner-Borja, Cristina Enjuanes, Marta de Antonio, Lara Fuentes, Carles Díez-López, Antoni Bayés-Genis, Nicolás Manito, Ramón Pujol, Josep Comin-Colet

Iron deficiency (ID) affects up to 50% of patients with chronic heart failure (HF). ID in patients with HF has been shown to be an independent adverse prognostic factor [1,2], it is associated with... more

Higher odds and rising trends in arrhythmia among young cannabis users with comorbid depression

14 May 2020
Author(s): Rupak Desai, Samarthkumar Thakkar, Harsh P Patel, Bryan E-Xin Tan, Nanush Damarlapally, Fariah Asha Haque, Nazia Farheen, Natalie DeWitt, Sejal Savani, Fahria Jessy Parisha, Rajkumar Doshi, Zeeshan Mansuri, Kishorbhai Gangani

The high prevalence of substance abuse especially cannabis among adolescents is one of the major health care challenges of the 21st century. The permissive nature of laws regarding cannabis use has... more


Stay informed on our latest news!


This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.