Sarcoidosis is a multisystem inflammatory disease of unknown etiology that manifests as non-caseating granulomas, predominantly in the lungs and intrathoracic lymph nodes, but possibly affecting any organ. Sarcoidal granulomas produce angiotensin-converting enzyme, and measurement of serum angiotensin-converting enzyme (SACE) activity is frequently part of the diagnostic workup of sarcoidosis. However, the value of SACE levels in diagnosing sarcoidosis remains controversial, due to suboptimal test specificity and sensitivity.
