Infective endocarditis (IE) has a significant in-hospital mortality [1]. There is evidence of improved clinical outcomes with protocols based on disease severity [2]. In this context, score-based risk stratification could direct high-risk patients to specialized or intensive care [3]. Although cardiac surgical risk scores have been developed for IE and compared with traditional risk scores [4], non-operated patients were not included. Therefore, optimization of their prognostic evaluation is needed.