October 2021
32 ArticlesNo Section
Detection of subclinical atrial fibrillation after cryptogenic stroke using implantable cardiac monitors
Despite extensive vascular and cardiological evaluations, the etiology of approximately one third of ischemic strokes cannot be definitively identified, resulting in their classification as... more
Efficacy of Belimumab for refractory systemic lupus erythematosus (SLE) involving the central nervous system
Neuropsychiatric manifestations of SLE (NPSLE) is associated with increased morbidity and mortality, intractable, complicating, and poor prognosis [1–3]. Although the severity of NPSLE correlates... more
Device-detected atrial high rate episodes and the risk of stroke/thrombo-embolism and atrial fibrillation incidence: a systematic review and meta-analysis
Modern Cardiac Implantable Electronic Devices (CIEDs) allow continuous monitoring of cardiac electrical activity through one or more electrodes. Atrial High Rate Episodes (AHRE) are defined as device... more
Non-HACEK gram negative bacilli endocarditis: Analysis of a national prospective cohort.
Infective endocarditis (IE) caused by Gram-negative bacilli (GNB) not included in the HACEK group (Haemophilus, Actinobacillus, Cardiobacterium, Eikenella corrodens, Kingella) is a rare infection... more
Commentary
Standardised PaO2/FiO2 ratio in COVID-19: Added value or risky assumptions?
The coronavirus disease 2019 (COVID-19) causes acute respiratory failure (ARF) altering the pulmonary microvasculature with simultaneous vasoconstriction and thrombosis in ventilated areas,... more
New insights in endocarditis caused by Gram negative bacilli not included in the HACEK group
Gram negative bacilli not included in the HACEK group (Haemophilus, Aggregatibacter spp -including A. Actinomycetemcomitans, A. Aprophilus, A. Paraphrophilus, A. Segnis-, Cardiobacterium, Eikenella... more
Long term consequences of COVID-19
On March 11, 2020, the coronavirus disease-2019 (COVID-19) was declared a pandemic by World Health Organization (WHO). While mainly affecting the respiratory system to the point of causing severe... more
Is coronary microvascular dysfunction a cause or a marker of worse outcomes in MINOCA patients?
Myocardial infarction in the absence of obstructive coronary artery disease (MINOCA) is a frequent clinical scenario observed in approximately 5% of all patients with acute myocardial infarction (AMI... more
Corrigendum
Corrigendum to: Antipsychotics and severe hyponatremia: A Swedish population-based case-control study. Eur J Intern Med. 2019 Feb;60:71-77.
The authors regret that in preparation of a new article based on the same data as in the previous published article [1], we unfortunately discovered two errors in the dataset. Some cases of... more
Corrigendum to: Tramadol- and codeine-induced severe hyponatremia: A Swedish population-based case-control study. Eur J Intern Med. 2019 Nov;69:20-24.
The authors regret that in preparation of a new article based on the same data as in the previous published article[1], we unfortunately discovered two errors in the dataset. Some cases of... more
Editorial
New insights in obesity development and possible value of microbiota transplantation
Obesity is possibly the most important non communicable disease of the 21st century. It has emerged from one of the “nutritional disorders” and has been suggested by the European Association for the... more
Ideas and Opinions
Exploring the possible link between myocarditis and mRNA COVID-19 vaccines
Myocarditis is an inflammatory cardiomyopathy, most frequently caused by viral agents, affecting 10-20 individuals per 100.000 each year in the general population [1]. Myocarditis (sometimes... more
One year on: The impact of COVID-19 on clinical research
During COVID-19 epidemic ongoing clinical research slowed down while an unprecedented amount of individual research on the infection broke out disproportionately with results, low respect to the... more
Internal Medicine Flashcard
Facial hypertrichosis, hyperpigmentation, and hepatosplenomegaly
A 51-year-old woman presented for evaluation of new-onset of facial hypertrichosis, hyperpigmentation and blistering on the back of the hands with sunlight exposure, additionally she referred change... more
Man with pruritic rash
A 41-year-old previously healthy man presented with a 3-day history of fevers, headache, abdominal pain, and pruritic rash. The rash began on his forehead and extended to the rest of his body. He had... more
A febrile patient with an unusual eruption
A 45-year-old man presented to dermatology outpatient department with complaints of sudden-onset, painful, clustered, monomorphic, punched-out erosions and ulcers, distributed symmetrically in the... more
Lupus pernio: Skin manifestation of systemic disease
62-year-old woman presented to our institution with the chief complaint of slowly progressive exertional dyspnea over the preceding two years in conjunction with a cough and facial rash. Physical... more
Letter to Editor
Validation of Takayasu arteritis, polyarteritis nodosa and Behcet's disease diagnosis codes in a French hospital database
Dear Editor,
Letter to the Editor
Quality of life in patients with antiphospholipid antibodies differs according to antiphospholipid syndrome damage index (DIAPS)
Antiphospholipid syndrome (APS) is an acquired thrombophilia characterized by the presence of confirmed antiphospholipid antibodies (aPL) positive testing with thrombotic events potentially occurring... more
Safety and efficacy of oral anticoagulants in atrial fibrillation and bioprosthetic heart valves
Atrial fibrillation (AF) is commonly encountered in clinical practice by internists and specialists, both in the inpatient and ambulatory settings. AF increases the risk of stroke or systemic... more
Comparison of supervised exercise therapy with or without revascularization for the management of intermittent claudication
Peripheral artery disease (PAD) affects about 8.5 million Americans aged ≥ 40 years and is associated with significant morbidity and mortality [1]. In patients with claudication, a supervised... more
Hyperhomocysteinemia in patients with acute porphyrias: a possible effect of ALAS1 modulation by siRNAm therapy and its control by vitamin supplementation
Acute hepatic porphyrias (AHPs) are a group of rare diseases caused by an enzymatic dysfunction in the biosynthesis of heme [1]. AHPs’ clinical landmarks are recurrent crisis of neurovisceral attacks... more
Recognition of sepsis in the pre-hospital environment one year after intensive traineeship
The mortality of sepsis patients presented by the Emergency Medical Services (EMS) with unrecognized sepsis is twice as high as in patients with documented sepsis [1]. To improve the (pre)-hospital... more
SHARPEN score accurately predicts in-hospital mortality in infective endocarditis
Infective endocarditis (IE) has a significant in-hospital mortality [1]. There is evidence of improved clinical outcomes with protocols based on disease severity [2]. In this context, score-based... more
Original Article
Standardizing PaO2 for PaCO2 in P/F ratio predicts in-hospital mortality in acute respiratory failure due to Covid-19: A pilot prospective study
Up to fifteen percent of patients with novel pandemic coronavirus disease (Covid-19) have acute respiratory failure (ARF). Ratio between arterial partial pressure of oxygen (PaO2) and fraction of... more
Prevalence of post-COVID-19 symptoms in hospitalized and non-hospitalized COVID-19 survivors: A systematic review and meta-analysis
The world is suffering a dramatic situation of catastrophic proportions due to the rapid worldwide spread of the coronavirus disease 2019 (COVID-19) caused by the pathogen acute respiratory syndrome... more
Clinical utility of antigen carbohydrate 125 for planning the optimal length of stay in acute heart failure
The optimal length of stay (LOS) in patients hospitalized for acute heart failure (AHF) remains uncertain [1]. Classically, more extended stays have been associated with a higher risk of in-hospital... more
Prognostic impact of coronary microvascular dysfunction in patients with myocardial infarction with non-obstructive coronary arteries
Myocardial infarction with non-obstructive coronary arteries (MINOCA) at coronary angiography (CAG) (stenosis
Autologous fecal microbiota transplantation can retain the metabolic achievements of dietary interventions
We recently reported that autologous fecal microbiota transplantation (aFMT), derived from the time of maximal weight-loss and administrated in the regain-phase, might preserve weight loss and... more
Review Article
State of the art approach to managing angina and ischemia: tailoring treatment to the evidence
Cardiovascular disease (CVD) is the most common cause of death and disability worldwide [1-5]. Stable angina represents a chronic, often life-long condition involving approximately 2% and 4% of the... more
Obesity and sleep disturbances: The “chicken or the egg” question
Since 1980 obesity has seen a rapid increase in global prevalence, that has almost doubled in many countries and nowadays affects more than 12% of the general population [1]. Interestingly, the rapid... more
Sweet taste and obesity
Obesity is associated with significant morbidity and mortality, and currently represents a global health challenge[1]. While it is associated with complex pathophysiology, increased availability of... more