September 2022

27 Articles

No Section

Validation of anti-neutrophil cytoplasm antibodies associated vasculitides diagnosis codes from the electronic health records of two French university hospitals

18 May 2022
Author(s): Camille Mettler, Samir Bouam, Sandra Liva-Yonnet, Gregory Pugnet, Benjamin Terrier

ANCA-associated vasculitides (AAV) are necrotizing vasculitis, with few or no immune deposit, predominantly affecting small vessels. Among AAV, granulomatosis with polyangiitis (GPA) is characterized... more


Not all the eggs and the chickens are the same: The case of uric acid and metabolic syndrome

20 July 2022
Author(s): Claudio Borghi, Federica Fogacci, Federica Piani

Uric acid represents the end-product of purine metabolism in humans and the great apes where it has played some evolutive roles over the time [1]. The production of uric acid is largely regulated by... more

The case of diabetes mellitus and atrial fibrillation: Underlining the importance of non-cardiovascular comorbidities

27 June 2022
Author(s): Marco Proietti, Giulio Francesco Romiti, Stefania Basili

In the currently changing scenario, in which our patients are progressively older and more likely burdened by concomitant chronic long-term conditions [1], diabetes mellitus (DM) play a prominent... more

Ideas and Opinions

Participants’ informed consent in adaptive, platform drug trials in hospitalized COVID-19 patients: Not all approaches are ethically acceptable

27 June 2022
Author(s): Rafael Dal-Ré, Arthur L Caplan, Teck Chuan Voo

One of the most exciting bits of news that the COVID-19 pandemic has provided in the clinical research arena is demonstrating that adaptive, platform randomized controlled trials (ad-RCTs) provided... more

Internal Medicine Flashcard

The hardest pill to swallow: A freak of nature

29 June 2022
Author(s): Eloy F. Ruiz, Muhammad Ahsan, Mehak M. Laharwal

Not required

A diabetic patient with finger gangrene

20 May 2022
Author(s): Sho Osonoi, Kiho Hamaura, Hiroshi Murakami

A 72-year-old male with type 2 diabetes and end-stage renal disease (ESRD) receiving hemodialysis (HD) for 10 months presented to hospital with one week of worsening pain, swelling, and bluish-black... more

Necrotic ulcers in an immunocompromised patient

19 May 2022
Author(s): Wan Syazween Lyana Wan Ahmad Kammal, Nur Shairah Mohamad Fazial, Adawiyah Jamil

A 68-year-old man presented to dermatology clinic with extensive ulcers for one-week duration. Patient had underlying uncontrolled Type II Diabetes Mellitus and pemphigus foliaceous. His medications... more

Letter to the Editor

Serum cystatin C, cystatin C level change and risk of atrial fibrillation

20 July 2022
Author(s): Odong Christopher, Yiquan Huang, Zhenyu Xiong, Xiaodong Zhuang, Xinxue Liao

Dear Editor,

Janus kinase inhibitors in patients with ankylosing spondylitis: Great news, but some concerns on cardiovascular disease risk still exist. Author's reply

12 July 2022
Author(s): Shu Li, Fen Li, Ni Mao, Jia Wang, Xi Xie

We appreciate the opportunity to reply to the Letter to the Editor by Dimosiari and colleagues [1], commenting on our work [2]. We concur with them that the cardiovascular disease (CVD) risk of Janus... more

Association of tenofovir and entecavir use with prognosis after surgical resection for hepatitis B virus-related hepatocellular carcinoma

11 July 2022
Author(s): Byungyoon Yun, Sang Hoon Ahn, Juyeon Oh, Jin-Ha Yoon, Beom Kyung Kim

Potent antiviral therapy (AVT) against hepatitis B virus (HBV) can induce regression of liver fibrosis, thereby reducing the development of liver cirrhosis and hepatocellular carcinoma (HCC) [1]. A... more

Ultrasound assessment of splanchnic circulation in Systemic Sclerosis: a non-invasive approach for the study of bowel vasculopathy?

9 July 2022
Author(s): Giulia Bandini, Esterita Accogli, Laura Cometi, Marco Matucci-Cerinic, Alberto Moggi Pignone

Dear editor,

Trends of thrombo-inflammation biomarkers after Tocilizumab predict treatment failure better than scores in patients with severe SARS-CoV2 related respiratory failure

5 June 2022
Author(s): Luca Masotti, Elisa Cioni, Elisa Grifoni, Francesco Cei, Roberto Tarquini

Cytokine antagonists are now concrete therapeutic options in patients with severe SARS-CoV2 respiratory failure. The Interleukin-6 (IL-6) inhibitor tocilizumab (TCZ) has shown to significantly reduce... more

Janus kinase inhibitors in patients with ankylosing spondylitis: Great news, but some concerns on cardiovascular disease risk still exist

3 June 2022
Author(s): Athina Dimosiari, Theodoros Michailidis, Dimitrios Patoulias

We have read with great interest the results of the meta-analysis conducted by Li and colleagues [1], demonstrating that Janus kinase (JAK) inhibitors are a safe treatment option for patients with... more

Ten year anniversary of choosing wisely campaigns

31 May 2022
Author(s): Omar Kherad, Antonio Vaz Carneiro, Choosing Wisely Working Group of the European Federation of Internal Medicine

We read with interest the perspective letter “Ten Years of Choosing Wisely to Reduce Low-Value Care” by Elizabeth J. Rourke [1]. As campaign leaders and members of the Choosing Wisely (CW) working... more

Syndrome of inappropriate antidiuresis as a maladaptive stress response shared by coronavirus disease 2019 and other cytokine storm disorders

30 May 2022
Author(s): Lorenzo Muccioli, Umberto Pensato, Maria Guarino, Francesca Bisulli, Marco Faustini Fustini

Dear Editor,

Original Article

Autoantibody positivity predicts severity of rheumatic immune-related adverse events to immune-checkpoint inhibitors

9 July 2022
Author(s): Corrado Campochiaro, Nicola Farina, Alessandro Tomelleri, Roberto Ferrara, Silvia Viola, Chiara Lazzari, Giacomo De Luca, Daniele Raggi, Alessandra Bulotta, Marco Matucci-Cerinic, Andrea Necchi, Marina Garassino, Vanesa Gregorc, Lorenzo Dagna

In the last decade, immune checkpoint inhibitors (ICIs) have become a therapeutic tool of paramount importance when managing malignancies. ICIs currently represent the standard of care for several... more

Epidemiology of subclinical atrial fibrillation in patients with cardiac implantable electronic devices: A systematic review and meta-regression

8 July 2022
Author(s): Marco Proietti, Giulio Francesco Romiti, Marco Vitolo, Marco Borgi, Arianna Di Rocco, Alessio Farcomeni, Kazuo Miyazawa, Jeff S Healey, Deirdre A Lane, Giuseppe Boriani, Stefania Basili, Gregory Y.H. Lip

In 1958 Senning and Elmqvist implanted the first permanent cardiac pacemaker (PM) to Arne Larsson, who survived for more than 40 years and ultimately died from different causes [1]. Since then, the... more

Nebivolol protects erectile functions compared to Metoprolol in hypertensive men with atherogenic, venogenic, psychogenic erectile dysfunction: A prospective, randomized, cross-over, clinical trial

23 June 2022
Author(s): Gokhan Gungor, Hakki Perk, Sedat Soyupek, Bahattin Baykal, Murat Demir, Mehmet Tugrul Sezer

Erectile dysfunction (ED) is defined as the inability to achieve or maintain a sufficient erection to engage in sexual intercourse [1]. Erectile functions are related to the quality of life of... more

Durable functional limitation in patients with coronavirus disease-2019 admitted to intensive care and the effect of intermediate-dose vs standard-dose anticoagulation on functional outcomes

19 June 2022

Coronavirus disease-2019 (COVID-19) has post-acute manifestations that may impact the everyday life functional and the mental health status of the affected patients [1]. In a cross-sectional global... more

Physician care access plays a significant role in extending global and regional life expectancy

14 June 2022
Author(s): Wenpeng You, Frank Donnelly

Life expectancy is a statistical measure for the average number of years a person in a population could expect to live based on current age and sex-specific death rates [1]. It has been the most... more

Do we need blood culture stewardship programs? A quality control study and survey to assess the appropriateness of blood culture collection and the knowledge and attitudes among physicians in Swiss hospitals

14 June 2022
Author(s): Sarah Dräger, Céline Giehl, Kirstine Kobberøe Søgaard, Adrian Egli, Mirjam de Roche, Lars C. Huber, Michael Osthoff

As bloodstream infections (BSI) are associated with a mortality of 14% and up to 35% in critically ill patients, physicians often have a low threshold to collect blood cultures (BC) [1–3]. But... more

Clinical characteristics of BRASH syndrome: Systematic scoping review

5 June 2022
Author(s): Parthav Shah, Maan Gozun, Koichi Keitoku, Nobuhiko Kimura, Jihun Yeo, Torrey Czech, Yoshito Nishimura

Bradycardia, renal failure, atrioventricular (AV) nodal blockade, shock, and hyperkalemia (BRASH) syndrome is a recently-established entity precipitated by medication-induced AV nodal blockade.... more

Impact of diabetes on the management and outcomes in atrial fibrillation: an analysis from the ESC-EHRA EORP-AF Long-Term General Registry

5 May 2022
Author(s): Wern Yew Ding, Agnieszka Kotalczyk, Giuseppe Boriani, Francisco Marin, Carina Blomström-Lundqvist, Tatjana S. Potpara, Laurent Fauchier, Gregory.Y.H. Lip, ESC-EHRA EORP-AF Long-Term General Registry Investigators

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, frequently associated with other conditions such as diabetes mellitus [1,2], and confers major healthcare costs [3]. Given... more

Review Article

COVID-19, vaccines and deficiency of ACE2 and other angiotensinases. Closing the loop on the "Spike effect"

21 June 2022
Author(s): Fabio Angeli, Gianpaolo Reboldi, Monica Trapasso, Martina Zappa, Antonio Spanevello, Paolo Verdecchia

The role of a dysregulated renin-angiotensin system (RAS) in the pathogenesis of COVID-19 is well recognized. The imbalance between angiotensin II (Ang II) and Angiotensin1-7 (Ang1,7) caused by the... more

From mid-range to mildly reduced ejection fraction heart failure: A call to treat

13 June 2022
Author(s): Davide Stolfo, Enrico Fabris, Lars H. Lund, Gianluigi Savarese, Gianfranco Sinagra

The historical classification of heart failure (HF) has considered two distinct subgroups, HF with reduced ejection fraction (HFrEF), generally classified as EF below 40%, and HF with preserved... more

Perspectives on the pharmacological management of alcohol use disorder: Are the approved medications effective?

18 May 2022
Author(s): Mariangela Antonelli, Luisa Sestito, Claudia Tarli, Giovanni Addolorato

Alcohol use disorder (AUD) is characterized by a large consumption of alcoholic beverages, which can determine the onset of alcohol-related diseases and an overall increase of morbidity and mortality... more

Uric acid in metabolic syndrome: Does uric acid have a definitive role?

1 May 2022
Author(s): Sidar Copur, Atalay Demiray, Mehmet Kanbay

The final product of purine metabolism is uric acid (UA) which is produced by xanthine oxidase (XO). Although most mammalian species can also oxidize UA to allantoin via uricase, humans are thought... more


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