Antisynthetase syndrome (ASyS), a rare and heterogeneous systemic autoimmune disease, is classified as a subtype of idiopathic inflammatory myopathy (IIM). It is associated with at least one of the following six criteria: interstitial lung disease (ILD), myositis, non-erosive arthritis, Raynaud's phenomenon, mechanic's hands, and unexplained fever. These manifestations are associated with autoantibodies against aminoacyl-transfer RNA synthetase (anti-ARS).
