September 2023

131 Articles

No Section

Safety of SARS-CoV-2 mRNA vaccines and effects of immunosuppressive drugs on adverse reactions in patients with rheumatic diseases

16 June 2023
Author(s): Mai Kawazoe, Junko Nishio, Wataru Hirose, Karin Furukawa, Toshihiro Nanki

Patients with rheumatic diseases (RD) have a higher rate of poor outcomes of coronavirus disease 2019 (COVID-19) [1]. The American College of Rheumatology (ACR) and the European League Against... more

A year later

Immune regulators for the treatment of COVID-19: A critical appraisal after two years

2 August 2023
Author(s): Nicola Farina, Lorenzo Dagna

More than three years have elapsed since the onset of the Coronavirus Disease 2019 (COVID-19) pandemic. Following the identification of this novel and intricate disease, clinicians and scientists... more

Beyond the Guidelines

2023 ESH Guidelines. What are the main recommendations?

1 August 2023
Author(s): Paolo Verdecchia, Ehud Grossmann, Paul Whelton

Generally, Clinical Practice Guidelines (CPG) are evidence-based recommendations, presented as summaries of the best available literature, which are aimed to assist doctors and other health care... more

Clinical Insights

Body Mass Index (BMI): Still be used?

13 September 2023
Author(s): Giovanna Muscogiuri, Ludovica Verde, Annamaria Colao

The Body Mass Index (BMI) is a commonly used measure that calculates an individual's body weight in relation to their height [1]. It was developed by Adolphe Quetelet in the early 19th century and... more

One year later: Prevalence of long-COVID symptoms

4 July 2023
Author(s): César Fernández-de-las-Peñas

It has been two years since the publication of one of the first meta-analyses investigating the prevalence of post-COVID symptomatology but differentiating between hospitalized and non-hospitalized... more

The spectrum of hospitalization-associated harm in the elderly

28 June 2023
Author(s): Ami Schattner

Hospital admission constitutes the standard of care for significant acute illness and have shown a marked and consistent worldwide increase over the last years. Nevertheless, not all admissions are... more

COVID-19 and smoking: Considerations after two years

24 May 2023
Author(s): Giuseppe Lippi, Brandon Michael Henry, Fabian Sanchis-Gomar

Although both virulence and pathogenicity of SARS-CoV-2 have considerably declined over time, the number of coronavirus disease 2019 (COVID-19) cases and the consequent clinical burden remain... more


Standing up for equitable treatment of coronary microvascular dysfunction and myocardial infarction with non-obstructive coronary arteries

25 September 2023
Author(s): Alexander C. Fanaroff, Renato D. Lopes

Myocardial infarction (MI) with normal coronary arteries (MINOCA) and ischemia with normal coronary arteries (INOCA) are syndromes characterized by evidence of myocardial necrosis or myocardial... more

Renal denervation trials in hypertension – what we wait for in 2023/2024

18 September 2023
Author(s): Felix Mahfoud, Michael Kunz, Felix Götzinger

Arterial hypertension is the most frequent modifiable cardiovascular risk factor and remains a leading cause of premature death worldwide with increasing prevalence [1]. Epidemiologic studies suggest... more

AMA-positivity in AIH-patients with bile duct lesions running in between. Novel findings and perspectives

7 August 2023
Author(s): Piero Portincasa, Leonilde Bonfrate, Agostino Di Ciaula

Autoimmune hepatitis (AIH) is a chronic, progressive inflammatory liver disease characterized by circulating autoantibodies and elevated serum globulin levels. If left untreated, AIH may progress to... more

Atherosclerosis in autoimmune rheumatic diseases

31 July 2023
Author(s): Zoltán Szekanecz, György Kerekes, Yehuda Shoenfeld

Autoimmune rheumatic and musculoskeletal diseases (RMDs) including rheumatoid arthritis (RA) and systemic sclerosis (SSc) and others have been associated with increased cardiovascular (CV) risk,... more

Gastrointestinal bleeding, a preventable cause of hospital admission: Time for specific studies in patients on antithrombotic therapy

28 July 2023
Author(s): Stefano Savonitto, Claudio Montalto, Stefano De Servi

Gastrointestinal bleeding (GIB) is a major cause of hospital admission, and in most cases has a iathrogenic cause. Administrative data from the United States report more than 400,000 hospital... more

Inflammatory puzzle: Unveiling the role of D-Dimer in acute pericarditis and thromboinflammation

27 July 2023
Author(s): Maddalena Alessandra Wu, Emanuele Bizzi, Antonio Brucato

In this issue of the European Journal of Internal Medicine, Lazaros et al. present the results of a prospective clinical study conducted in a tertiary referral center to investigate the potential... more

Modern technology meets established health care. Challenges and opportunities in fulfilling the promises of remote device monitoring in heart failure

25 July 2023
Author(s): Frieder Braunschweig

In 1961, American astronaut Alan Shepard became the second human being travelling into space. Onboard the spacecraft, some of his vital parameters, heart rate and rhythm, body temperature and... more

Unwarranted clinical practice variation and resource overutilization in medical care: The example of transfusion practices in elderly hospital patients

21 July 2023
Author(s): António Vaz Carneiro

Clinical practice variation refers to the differences in healthcare practices and treatment decisions among healthcare providers, for patients with similar clinical conditions [1]. These variations... more

The arduous challenge of seeking for biomarkers in rare diseases

14 July 2023
Author(s): Patrizia Suppressa, Luigi Rizzi

Hereditary haemorrhagic telangiectasia (HHT) is a rare genetic vascular disease that can significantly impair the quality of life of affected patients [1]. Medical management is mainly aimed at... more


Corrigendum to ‘Clinical outcomes associated with the emergency treatment of hyperkalaemia with intravenous insulin-dextrose’ [European Journal of Internal Medicine 95C (2021) 87-92]

26 August 2023
Author(s): Toby J.L. Humphrey, Glen James, Ian B Wilkinson, Thomas F. Hiemstra

The authors regret that the supplementary material was not published with their above article.

Corrigendum to ‘Creatinine: From physiology to clinical application’[European Journal of Internal Medicine 72C (2020) 9-14]

27 July 2023
Author(s): Kianoush Kashani, Mitchell H. Rosner, Marlies Ostermann

The authors regret that there was an error in Figure 1 of the above published article. In this figure, the second yellow box from the top reads "Creatinine Phosphate," while it should read "Creatine... more


The new international nomenclature for steatotic liver disease: One step forward towards enhanced awareness for healthier life

14 September 2023
Author(s): Karel J. van Erpecum, Laurens A. van Kleef, Ulrich Beuers, Robert J. de Knegt

Steatotic liver disease (SLD) is the most common liver disease worldwide and a leading cause of liver-related morbidity and mortality. Current prevalence of SLD is approximately 30 % of the global... more

Ideas and Opinions

Addressing the paradox: Health expansion threatening sustainable healthcare

19 September 2023
Author(s): Bjørn Hofmann

We need to address the paradox that health expansion threatens sustainable healthcare as anti-aging drugs are on the trail from trial to the market and come together with health enhancement measures... more

Internal Medicine Flashcard

Sudden onset of left hemiplegia

2 September 2023
Author(s): Zhiwei Zhou, Tijiang Zhang, Ping Xu

A 65-year-old male presented with sudden onset of left hemiplegia for four hours, he was confused, blood pressure 158/109 mmHg, slightly delayed response, dysarthria, the muscle strength was 4/5 in... more

Respiratory failure following upper gastrointestinal endoscopy: A rare and unanticipated outcome to look out for

1 September 2023
Author(s): Ana Carolina Monteiro, Tomás França de Santana, Martim Trovão Bastos

A 67-year-old male patient was admitted to the Emergency Department with a one-week history of hematemesis and melaena. He was known to have liver cirrhosis secondary to alcoholic liver disease. Upon... more

Young woman with red eyes and shock

22 August 2023
Author(s): Hiroki Matsuura, Masayuki Kishida

A 21-year-old previously healthy Japanese woman with one-week history of fever, sore throat, chills, nausea, vomiting, abdominal pain, and watery diarrhea presented to our emergency department.... more

Ring-like late gadolinium enhancement

12 August 2023
Author(s): Yuan Yao, Ting Liu, Qing Zhang

Dear Editor,

Unusual cause of chronic cough and bloody phlegm with Atypical pulmonary CT findings

11 August 2023
Author(s): Hiroki Matsuura, Shouta Yuzurio, Shinichi Mukai

A 42-year-old man with 3-month history of chronic dry cough and bloody phlegm was presented to our respiratory outpatient department. He had no previous significant medical history. He also denied... more

Continuous annular calcification of intestinal wall

3 August 2023
Author(s): Jingyi Chen, Hongli Lin, Longkai Li

A 49-year-old female patient received peritoneal dialysis (PD) for six years but has switched to hemodialysis for two years due to poor peritoneal ultrafiltration. She was admitted because of nausea... more

A man with widespread subcutaneous fat necrosis and osteonecrosis

1 August 2023
Author(s): Shu Yoshihara, Shioto Suzuki, Taku Yaegashi

A man in his forties with a history of alcohol abuse (200 g/day) presented with progressive multiple joint pain. He did not have abdominal, respiratory or urinary complaints. Physical examination... more

Unusual cause of acute severe epigastric pain in a Japanese woman

28 June 2023
Author(s): Hiroki Matsuura, Rio Fujita

A 42-year-old woman with 2-day history of acute onset severe epigastric pain, nausea, and vomiting presented to our emergency department. She had no previous significant cardiovascular or... more

A man with bright-golden orange phlegm

10 May 2023
Author(s): Jun Hirai, Nobuaki Mori, Hiroshige Mikamo

A 57-year-old Japanese man with a history of hypertension was admitted to our hospital complaining of headache and fatigue that started 3 days before. On admission, his consciousness was clear. He... more

Bad luck comes in threes

9 May 2023
Author(s): D Vandermeersch, P-Y Sansen, L Pothen

An 84-year-old Caucasian woman presented to our clinic with a diffuse erythematous skin eruption associated with fever and fatigue. The patient has a two-month-old diagnosis of cortico-resistant... more

Letter to the Editor

Interleukin-6 inhibition for the treatment of IgG4 related vasculitis

16 September 2023
Author(s): Veronica Batani, Claudia Minici, Francesca Sanvito, Elena Venturini, Emanuel Della-Torre, IgG4-RD OSR Clinic

Dear Editor

CHEDDAR score versus YEARS algorithm for suspected pulmonary embolism in SARS-CoV-2-infected patients: A comparison of two strategies

16 September 2023
Author(s): Anabel Franco-Moreno, Aida Izquierdo-Martínez, Idoia Pagai-Valcárcel, Juan Torres-Macho, Cristina Lucía de Ancos-Aracil, CHEDDAR Research Group

Patients with clinically suspected pulmonary embolism (PE) should be managed according to standardized flowcharts. These flowcharts include validated algorithms to determine pretest probability, d-... more

Performance of multi-biomarker panels based on urinary N-terminal osteopontin for prediction of diabetic kidney disease in patients with diabetes mellitus

13 September 2023
Author(s): Ling Sun, Yu Wu, Satyesh K. Sinha, Susanne B. Nicholas, Lu-Xi Zou

Diabetic kidney disease (DKD), defined as chronic kidney disease (CKD) attributed to diabetes mellitus (DM), is the leading cause of end-stage renal disease (ESRD) and is associated with increased... more

The old and the new: The EG.5 (‘Eris’) sub-variant of Coronavirus

8 September 2023
Author(s): Martina Zappa, Paolo Verdecchia, Andrea Andolina, Fabio Angeli

In the last year of pandemic, several variants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) have been identified and monitored. Indeed, the persisting challenges of SARS-CoV-2 to... more

Extreme anemia (hemoglobin < 5 G/DL) at the emergency department

8 September 2023
Author(s): Sami Mustajoki, Anttimikael Heikkilä

Dear Editor,

Exploring sarcoidosis systemic treatment: Patient factors and therapeutic strategies

7 September 2023
Author(s): Rafiqur Rahman, FNU Samiullah, Satesh Kumar

Dear Editor,

Long-term efficacy and safety of secukinumab in patients with psoriatic arthritis

6 September 2023
Author(s): Aysal Mahmood, Abraish Ali, Hoorain Haider, Beenish Zulfiqar

Psoriatic arthritis (PsA) is a chronic inflammatory autoimmune disease that can adversely affect functional capabilities, if left untreated, leading to irreparable damage to joint spaces [1].... more

Dosing of iodixanol for predicting acute kidney injury in patients undergoing elective percutaneous coronary intervention

5 September 2023
Author(s): Zaiyan Chen, Ning Zhao, Yan Zhang, Ranzun Zhao, Xiaohui Zhao

A dose of iodinated contrast over the maximum allowable contrast dose (MACD) of 300 mL has been considered as a major factor leading to acute kidney injury (AKI) [1]. However, we found that the... more

Fixing the Achilles heel of electronic medical records: Vital information must be defined, concise, accurate and easily accessible

25 August 2023
Author(s): John Kellett, Niclas Skyttberg, Rijk Gans, Frank Sebat, Runolfur Palsson

Although electronic medical records (EMR) have many potential benefits, one of their unintended consequences it that many physicians may now spend most of their working hours at a computer screen... more

Does a multidisciplinary team involving internists specialized in hypertension and obstetric medicine improve pregnancy outcomes?

20 August 2023
Author(s): Federica Piani, Daniela Degli Esposti, Davide Agnoletti, Claudio Borghi, Bologna HDP Study Group

The prevalence of hypertensive disorders of pregnancy (HDP) steadily increased in past years partly because of advanced maternal age and partly because of ever-wider access to assisted reproduction... more

Polyautoimmunity in IgG4-related disease

17 August 2023
Author(s): Gabriela Hernández-Molina, Eduardo Martín-Nares

Dear Editor,

Diagnoses associated with temporal arteritis

14 August 2023
Author(s): Fabien Pontille, Paul Decker, Guillaume Gauchotte, Roland Jaussaud, Thomas Moulinet

The diagnosis of giant cell arteritis (GCA), the most common vasculitis after the age of 50, relies on a body of evidence, among which temporal arteritis (TA) remains a cornerstone [1]. However, TA... more

Spontaneous coronary artery dissection and Takotsubo syndrome

14 August 2023
Author(s): Andrea Denegri, Lukasz Szarpak, Michal Pruc, Milosz J. Jaguszewski

Spontaneous coronary artery dissection (SCAD) and Takotsubo syndrome (TTS) are increasingly recognized. Both conditions predominantly affect females, with an incidence of up to 4% in patients... more

Undiagnosed cognitive impairment in older adults hospitalized in internal medicine wards: Data from the REPOSI registry

4 August 2023
Author(s): Pasquale Agosti, Alessio Novella, Carlo Custodero, Chiara Elli, Luca Pasina, REPOSI Investigators

Dear Editor,

Prognostic role of the left ventricular global function index companion in patients with chronic heart failure

31 July 2023
Author(s): Vera N. Larina, Viktor I. Lunev

Heart failure (HF) is characterized by significant morbidity, mortality, economic burden and low quality of life. The global prevalence of HF among patients aged 50 years and older averages 8.3%, the... more

The higher the serum albumin, the better? Findings from the PRACTICE study

31 July 2023
Author(s): Ying-Ying Zheng, Ting-Ting Wu, Xian-Geng Hou, Yi Yang, Hai-Tao Yang, Ying Pan, Wen-Juan Xiu, Xiang Ma, Yi-Tong Ma, Xiang Xie

The relation between hypoalbuminemia and coronary artery disease (CAD) has been established. However, the association of increased albumin level and outcomes of CAD has not been investigated.

Autoantibodies against an immunodominant epitope from apolipoprotein B and risk of cardiovascular events in subjects with type 2 diabetes

26 July 2023
Author(s): Viviane Aparecida R. Sant'Anna, Maria Cristina O. Izar, Magnus Gidlund, Henrique Andrade R. Fonseca, Vaccine Heart Group

Patients with diabetes mellitus (DM) have accelerated atherosclerosis progression and increased cardiovascular morbidity and mortality. Therefore, patients with type 2 DM (T2DM) are increasing in the... more

Risk factors for high-risk human papillomavirus cervical infection and clearance in patients with systemic lupus erythematosus

23 July 2023
Author(s): Tiphaine Goulenok, Valentine Marie Ferré, Arthur Mageau, Thomas Papo, Karim Sacré

Women with systemic lupus erythematosus (SLE) are at higher risk of high grade cervical squamous intraepithelial lesions [1]. Inadequate immune response may impair the clearance of cervical human... more

Ethics of death pronouncement

21 July 2023
Author(s): Zubia Afzal, Abdul Rehman Gull

Death is the only certainty we have in life. While everyone knows that human life is supposed to end but no one is fully prepared to embrace it, neither his own nor his loved ones. The death of a... more

Causal diagrams to compare randomized trials: The case of Early Goal-Directed Therapy for sepsis

21 July 2023
Author(s): Isaac Núñez, Adrian Soto-Mota

Performing a randomized controlled trial (RCT) is considered the best way to answer a causal question in clinical research [1]. While RCTs are frequently designed in close collaboration by physicians... more

B-cell depletion with obinutuzumab for the treatment of IgG4-related disease

21 July 2023
Author(s): Marco Lanzillotta, Paola Mapelli, Lorenzo Dagna, Emanuel Della-Torre

IgG4-related disease (IgG4-RD) is an increasingly recognized fibro-inflammatory disorder that can lead to end-stage organ damage if left untreated [1]. Glucocorticoids have been historically... more

Inotropes administration in patients with acute infective endocarditis and indication for urgent cardiac surgery

18 July 2023
Author(s): Lorenzo Bertolino, Tommaso Marrazzo, Filomena Boccia, Rosa Zampino, Emanuele Durante-Mangoni

Heart failure (HF) is the most common complication of acute infective endocarditis (IE), occurring in 42–60% of patients [1–2]. HF is mainly related to aortic or mitral regurgitation, but associated... more

Persistently raised blood pressure following coronavirus disease 2019 vaccines: Implication for future systematic research and monitoring

14 July 2023
Author(s): Samadhi Patamatamkul, Maythinee Potongcamphan

During the global coronavirus disease 2019 (COVID-19) pandemic, an extensive immunisation programme was initiated worldwide. Subsequent to a comprehensive vaccination campaign, emerging evidence... more

Acute venous thromboembolism in the emergency department: Inpatient versus outpatient management trends from 2016 to 2019

13 July 2023
Author(s): Maria F Grande Ratti, María A Duhart, Ignacio M Bluro, Federico Sberna, Fernando J Vazquez

Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), poses a significant public health concern [1]. It stands as the primary cause of morbidity and... more

Prevalence and characteristics of post COVID-19 condition five months after SARS-COV-2 infection in inpatients and outpatients.

8 July 2023
Author(s): Ivonne Chong, Jan A. Roth, Balthasar L Hug

We are well aware of the worldwide problems caused by the COVID-19 pandemic and thanks to health measures such as vaccination this situation has been positively controlled.

The efficacy and safety of out-hospital anticoagulation therapy with direct oral anticoagulant for COVID-19

28 June 2023
Author(s): Yu Geng, Chang Meng, Tong Gao, Ping Zhang, Yintang Wang

As coronavirus disease 2019 (COVID-19) has caused unprecedented morbidity and mortality in the global pandemic, effective strategies to treat and prevent the disease are urgently needed.... more

Clinically significant contrast-associated acute kidney injury after emergent computed tomography angiography of the cerebral arteries

12 June 2023
Author(s): Mariana Barosa, Tiago Barroso, Ricardo Marques, Joana Caetano, José Delgado Alves

Contrast associated acute kidney injury (CA-AKI) is defined as a sudden deterioration in renal function within 48 h following the intravascular administration of iodinated contrast medium[1]. CA-AKI... more

Association between diagnostic outcomes and symptom pattern in fever and inflammation of unknown origin

7 June 2023
Author(s): A. Betrains, L. Moreel, W.F. Wright, D. Blockmans, S. Vanderschueren

Fever of unknown origin (FUO) and inflammation of unknown origin (IUO) are syndromes that share a similar spectrum of causes and that are separated by an arbitrary temperature threshold [1]. They... more

A higher BMI is positively associated with advanced neck lymphoma at diagnosis

3 June 2023
Author(s): Mahmud Darawshe, Luiza Akria, Netanel A. Horowitz, Ohad Ronen

Lymphomas comprise a heterogeneous group of malignancies which can arise in different nodal and extranodal sites in the head and neck in which cervical lymphadenopathy is the most common head and... more

Comprehensive diagnostic evaluation of palpatory method of blood pressure measurement

31 May 2023
Author(s): Yogita Kumar, Pawan Kumar Singh, Dhruva Chaudhry, Amit Sharma, Pooja Yadav

Dear Editor,

Frailty in nursing home residents

29 May 2023
Author(s): Mario Rizzo, Antonella Pansini, Marisanta Colucci, Eugenio Boccalone, Pasquale Mone

Dear Editor,

Impact of the COVID-19 pandemic on the occurrence and outcome of cardiogenic shock complicating acute myocardial infarction

28 May 2023
Author(s): Zuzana Motovska, Ota Hlinomaz, Jan Mrozek, Petr Kala, Jiri Jarkovsky

SARS-CoV-2 predisposes patients to thrombotic disease due to excessive inflammation, platelet activation, endothelial dysfunction, and stasis [1]. The infection was recognized as an independent risk... more

Characteristics and outcomes of COVID-19-associated pulmonary embolism

25 May 2023
Author(s): Ramy Sedhom, Amr Mohsen, Liset Stoletniy, Dmitry Abramov, Islam Y. Elgendy

Pulmonary embolism (PE) in the setting of COVID-19 is related to the procoagulant state as evidenced by the increased d-dimer levels and in situ thrombosis [1,2] and it usually involves the segmental... more

Original Article

Asymptomatic vs. symptomatic atrial fibrillation: Clinical outcomes in heart failure patients

25 September 2023
Author(s): Giuseppe Boriani, Niccolo’ Bonini, Marco Vitolo, Davide A Mei, Jacopo F Imberti, Luigi Gerra, Giulio Francesco Romiti, Bernadette Corica, Marco Proietti, Igor Diemberger, Gheorghe-Andrei Dan, Tatjana Potpara, Gregory YH Lip

Atrial fibrillation (AF) is the most common arrhythmia worldwide, afflicting patients’ prognosis and symptoms. The European Heart Rhythm Association (EHRA) proposed the EHRA score for grading the... more

Legionella pneumonia in hospitalized adults with respiratory failure: Quinolones or macrolides?

18 September 2023
Author(s): Alfonsina Ruiz-Spinelli, Jordi Rello

Legionellosis represents an important public health problem throughout the world, although it is considered as an underdiagnosed and underreported disease. Morbidity and mortality remain high, as... more

Impact of bronchoalveolar lavage on the management of immunocompromised hosts

16 September 2023
Author(s): Kathleen Jahn, Meropi Karakioulaki, Desiree M. Schumann, Hans H. Hirsch, Karoline Leuzinger, Leticia Grize, Stefano Aliberti, Giovanni Sotgiu, Michael Tamm, Daiana Stolz

BAL leads to changes in management in the majority of immunosuppressed patients. There is a high prevalence of multimicrobial infections and respiratory viral infections in immunocompromised patients... more

New genetic drivers in hemorrhagic hereditary telangiectasia

7 September 2023
Author(s): Pau Cerdà, Sandra D. Castillo, Cinthia Aguilera, Adriana Iriarte, José Luis Rocamora, Ane M. Larrinaga, Francesc Viñals, Mariona Graupera, Antoni Riera-Mestre

Hereditary hemorrhagic telangiectasia (HHT) or Rendu–Osler–Weber syndrome (ORPHA:774) is a rare autosomal dominant vascular disease characterized by the presence of telangiectases and larger vascular... more

Prognostic significance of quantitative electrocardiographic parameters in patients with non-high-risk pulmonary embolism

5 September 2023
Author(s): Xin-Xin Yan, Hong-Da Zhang, Fu-Hua Peng, Lei Ding, Li-Jie Mi, Ai-Kai Zhang, Lu Hua, Min Tang

Acute pulmonary embolism (PE), a common acute cardiovascular disease, has an annual incidence of 39∼120 cases per 100 000 population [1,2]. The incidence is increasing because of global population... more

Abatacept in usual and in non-specific interstitial pneumonia associated with rheumatoid arthritis

4 September 2023
Author(s): Belén Atienza-Mateo, Carlos Fernández-Díaz, Esther F. Vicente-Rabaneda, Rafael B. Melero-González, Francisco Ortiz-Sanjuán, Ivette Casafont-Solé, Sebastián C. Rodríguez-García, Iván Ferraz-Amaro, Santos Castañeda, Ricardo Blanco, Spanish Collaborative Group of Abatacept in Interstitial Lung Disease Associated with Rheumatoid Arthritis

Interstitial lung disease (ILD) is a severe and frequent extraarticular manifestation of rheumatoid arthritis (RA). A higher mortality rate in patients with RA-ILD in comparison with those without... more

The Long-COVID autonomic syndrome in hospitalized patients: A one-year prospective cohort study

29 August 2023
Author(s): Stefano Rigo, Franca Barbic, Kareem Khalaf, Andrea Bisoglio, Margherita Pani, Maura Minonzio, Luca Rinaldi, Michele Ciccarelli, Maria Grazia Bordoni, Paolo Verzeletti, Fabio Badilini, Stefanos Bonovas, Daniele Piovani, Dana Shiffer, Raffaello Furlan

A growing body of evidence [1–6] suggests that some patients who survive an acute SARS-CoV-2 viral infection (COVID-19) may experience persistent symptoms for months, resulting in a clinical syndrome... more

Novel potassium binders to optimize RAASi therapy in heart failure: A systematic review and meta-analysis

28 August 2023
Author(s): Stefania Paolillo, Christian Basile, Simona Dell'Aversana, Immacolata Esposito, Alfonsina Chirico, Angela Colella, Gennaro Esposito, Mariafrancesca Di Santo, Maria Francesca Fierro, Francesca Carbone, Federica Marzano, Chiara Amato, Paola Gargiulo, Pasquale Perrone Filardi

Heart failure (HF) is a major cause of cardiovascular (CV) mortality and morbidity, resulting in more than one million hospitalizations per year. In patients affected by HF with reduced ejection... more

Efficacy and safety of direct oral anticoagulants vs vitamin K antagonists in patients with atrial fibrillation and end-stage renal disease on hemodialysis: A systematic review and meta-analysis

28 August 2023
Author(s): Ioannis Kyriakoulis, Anastasia Adamou, Iliana Stamatiou, David Dimitris Chlorogiannis, Ioannis Kardoutsos, Despoina Koukousaki, George Ntaios

The prevalence of atrial fibrillation (AF) in individuals with end stage renal disease (ESRD) who are on chronic hemodialysis is increasing, exceeding that of the general population and resulting in... more

Renin‐angiotensin-aldosterone system inhibitors and mortality risk in elderly patients with atrial fibrillation. Insights from the nationwide START registry

28 August 2023
Author(s): Danilo Menichelli, Daniela Poli, Emilia Antonucci, Gualtiero Palareti, Pasquale Pignatelli, Daniele Pastori, the START2 Register Investigators

The estimated prevalence of atrial fibrillation (AF) in the general population is about 1–4% and rises according to aging [1]. Cardiovascular comorbidities are utmost prevalent in patients with AF,... more

Infarct severity and outcomes in ST-elevation myocardial infarction patients without standard modifiable risk factors – A multicenter cardiac magnetic resonance study

25 August 2023
Author(s): Martin Reindl, Thomas Stiermaier, Ivan Lechner, Christina Tiller, Magdalena Holzknecht, Priscilla Fink, Agnes Mayr, Gert Klug, Hans-Josef Feistritzer, Ronak Delewi, Alexander Hirsch, Jaclyn Carberry, David Carrick, Axel Bauer, Bernhard Metzler, Robin Nijveldt, Holger Thiele, Colin Berry, Ingo Eitel, Sebastian J. Reinstadler

Ischemic heart disease remains a leading contributor to the burden of cardiovascular disease with 1.8 million annual deaths in Europe [1]. The annual incidence of hospital admissions for acute... more

Predictive value of Killip classification in MINOCA patients

16 August 2023
Author(s): Matteo Armillotta, Sara Amicone, Luca Bergamaschi, Francesco Angeli, Andrea Rinaldi, Pasquale Paolisso, Andrea Stefanizzi, Angelo Sansonetti, Andrea Impellizzeri, Francesca Bodega, Lisa Canton, Nicole Suma, Damiano Fedele, Davide Bertolini, Alberto Foà, Carmine Pizzi

In the last two decades, the better understanding of acute myocardial infarction (AMI) pathophysiology as well as the advances in medical therapy and hemodynamical techniques led to a decrease in the... more

Value of inflammatory response and oxidative damage in the diagnosis of infections in severe alcoholic hepatitis

14 August 2023
Author(s): Onán Pérez-Hernández, Emilio González-Reimers, Alen García-Rodríguez, Camino Fernández-Rodríguez, Pedro Abreu-González, José María González-Pérez, María José Sánchez-Pérez, Iván Ferraz-Amaro, Candelaria Martín-González

Alcohol is one of the most consumed substances in the world. Among the organic lesions produced by alcohol consumption, liver disease has been the most studied and documented. Alcohol use disorder is... more

Impact of antimicrobial stewardship in organisms causing nosocomial infection among COVID-19 critically ill adults

12 August 2023
Author(s): Loreto Vidaur, Itziar Eguibar, Ander Olazabal, Maialen Aseguinolaza, Oihana Leizaola, Amalur Guridi, Maria Teresa Iglesias, Jordi Rello

Since the firsts reports of a novel viral respiratory illness emerged in December 2019 in Hubei province, China [1], the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) has infected... more

Anticoagulation strategies and long-term recurrence in patients with venous thromboembolism in the era of direct oral anticoagulants

11 August 2023
Author(s): Kazuhisa Kaneda, Yugo Yamashita, Takeshi Morimoto, Ryuki Chatani, Yuji Nishimoto, Nobutaka Ikeda, Yohei Kobayashi, Satoshi Ikeda, Kitae Kim, Moriaki Inoko, Toru Takase, Shuhei Tsuji, Maki Oi, Takuma Takada, Kazunori Otsui, Takeshi Kimura, COMMAND VTE Registry-2 Investigators

Venous thromboembolism (VTE), including pulmonary embolism (PE) and deep vein thrombosis (DVT), is a major health problem all over the world [1]. VTE has a long-term risk of recurrence, and the... more

Immunosuppressive therapy and oral anticoagulation in kidney transplant recipients: Direct oral anticoagulants versus vitamin-k antagonists

10 August 2023
Author(s): Francesco Santoro, Annalisa Casanova, Simona Simone, Carlo Alfieri, Adele Falcone, Andrea Dello Strologo, Valeria Grandinetti, Marco Busutti, Giorgia Comai, Tommaso Maria Marvulli, Maria Grazia Zippo, Giuseppe Castellano, Gaetano La Manna, Loreto Gesualdo, Grandaliano Giuseppe, Francesco Pesce

Kidney transplant recipients (KRTs), have an increased risk of atrial fibrillation that has an incidence of about 7% in the first 3 years after transplantation 1. Moreover, the risk of thromboembolic... more

Haemoglobin levels as a predictor for the occurrence of future cardiovascular events in adults–Sex-dependent results from the EPIC trial

8 August 2023
Author(s): Christian Jung, Ralf Erkens, Patricia Wischmann, Kerstin Piayda, Malte Kelm, Gunter Kuhnle

Anemia, defined by the World Health Organization (WHO) as hemoglobin (HGB) levels

Elevated levels of IL-6 in IgA nephropathy patients are induced by an epigenetically driven mechanism modulated by viral and bacterial RNA

5 August 2023
Author(s): Fabio Sallustio, Angela Picerno, Maria Teresa Cimmarusti, Francesca Montenegro, Claudia Curci, Giuseppe De Palma, Carmen Sivo, Francesca Annese, Giulia Fontò, Alessandra Stasi, Francesco Pesce, Silvio Tafuri, Vincenzo Di Leo, Loreto Gesualdo

Immunoglobulin A nephropathy (IgAN), also known as Berger's disease, is the most frequent primary glomerulonephritis characterized by the presence of IgA immune complexes in the glomeruli [1]. It... more

Clinical features and immune mechanisms directly linked to the altered liver function in patients with rheumatoid arthritis

4 August 2023
Author(s): I Arias-de la Rosa, M Ruiz-Ponce, L Cuesta-López, C Pérez-Sánchez, F Leiva-Cepas, MD Gahete, P Navarro, R Ortega, J Cordoba, E Pérez-Pampin, A González, AJ Lucendo, E Collantes-Estévez, Ch López-Pedrera, A Escudero-Contreras, N Barbarroja

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that mainly affects the synovial membrane, cartilage, and bone tissue, and is associated with progressive disability, systemic... more

Catheter-based renal artery denervation: facts and expectations

4 August 2023
Author(s): Paolo Verdecchia, Claudio Cavallini, Rocco Sclafani, Andrea Santucci, Francesco Notaristefano, Gianluca Zingarini, Giovanni Andrea Colombo, Fabio Angeli

Some clinical studies published before year 2014 raised consistent expectations worldwide on a promising role of catheter-based renal artery denervation (RAD) in the management of patients with... more

Performance of admission pathways within acute medicine services: Analysis from the Society for Acute Medicine Benchmarking Audit 2022 and comparison with performance 2019 - 2021

3 August 2023
Author(s): Catherine Atkin, Thomas Knight, Tim Cooksley, Mark Holland, Chris Subbe, Adrian Kennedy, Ragit Varia, Adnan Gebril, Daniel Lasserson

Healthcare services are under huge strain, with rising Emergency Department (ED) attendances, increased waiting times for ED assessment and increasing pressures within inpatient services in acute... more

Relationships between education and non-alcoholic fatty liver disease

2 August 2023
Author(s): Florian Koutny, Elmar Aigner, Christian Datz, Sophie Gensluckner, Andreas Maieron, Andrea Mega, Bernhard Iglseder, Patrick Langthaler, Vanessa Frey, Bernhard Paulweber, Eugen Trinka, Bernhard Wernly

Affecting up to 30% of the adult population in western countries, non-alcoholic fatty liver disease (NAFLD) is a worldwide public health problem [1,2]. Because 5% of individuals with NAFLD suffer... more

Short-term prognosis of changes in plasma potassium following an episode of hyperkalaemia in patients with chronic heart failure

28 July 2023
Author(s): Sofie Solhøj Jønsson, Sofie Amalie Sørensen, Sidse Thim Krøgh, Dorte Melgaard, Peter Søgaard, Marc Meller Søndergaard, Peter Leutscher, Kristian Kragholm, Mette Aldahl, Christian Torp-Pedersen, Maria Lukács Krogager

Chronic heart failure (HF) is an increasing problem in public healthcare and is associated with considerable morbidity and mortality [1]. HF affects approximately 23 million people worldwide,... more

Non-eligibility for pivotal HFpEF/HFmrEF outcome trials and mortality in a contemporary heart failure cohort

28 July 2023
Author(s): Viktoria Santner, Hermann S. Riepl, Florian Posch, Markus Wallner, Peter P. Rainer, Klemens Ablasser, Ewald Kolesnik, Viktoria Hoeller, David Zach, Nora Schwegel, Philipp Kreuzer, Andreas Lueger, Johannes Petutschnigg, Burkert Pieske, Andreas Zirlik, Frank Edelmann, Nicolas Verheyen

Heart failure with preserved (HFpEF) and mildly reduced ejection fraction (HFmrEF) account for more than half of all heart failure decompensations [1]. Patients are exposed to a high risk of... more

Thymic stromal lymphopoietin (TSLP) is a substrate for tryptase in patients with mastocytosis

25 July 2023
Author(s): Simone Marcella, Angelica Petraroli, Luisa Canè, Anne Lise Ferrara, Remo Poto, Roberta Parente, Francesco Palestra, Leonardo Cristinziano, Luca Modestino, Maria Rosaria Galdiero, Maria Monti, Gianni Marone, Massimo Triggiani, Gilda Varricchi, Stefania Loffredo

Mastocytosis is a heterogeneous, rare disease associated with uncontrolled proliferation, accumulation, and increased survival of mast cells (MCs) in different organs [1]. This pathological condition... more

Six-month cardiovascular prognostic impact of type 1 And type 2 myocardial infarction in patients hospitalized for gastrointestinal bleeding

25 July 2023
Author(s): Gayatri Pemmasani, Ashwini Ashwath, Wilbert S. Aronow, Srikanth Yandrapalli, Jonathan Leighton, Savio John

Gastrointestinal bleeding (GIB) is a major healthcare concern that poses significant clinical and economic burden. It is associated with high morbidity, mortality, and healthcare expenditure. In the... more

Predicting acute and long-term mortality in a cohort of pulmonary embolism patients using machine learning

22 July 2023
Author(s): Wahbi K. El-Bouri, Alexander Sanders, Gregory Y.H. Lip, BBC-VTE investigators

Venous thromboembolism (VTE), including both pulmonary embolism (PE) and deep vein thrombosis (DVT), is a severe condition that causes significant mortality and morbidity in the acute phase, with a... more

GLIM-diagnosed malnutrition predicts mortality and risk of hospitalization in systemic sclerosis: A retrospective study

21 July 2023
Author(s): Edoardo Rosato, Antonietta Gigante, Amalia Colalillo, Chiara Pellicano, Danilo Alunni Fegatelli, Maurizio Muscaritoli

Systemic sclerosis (SSc) is an autoimmune disease characterized by microcirculation dysfunction, autoantibodies production, progressive skin and multiorgan fibrosis with potentially life-threatening... more

Prevalence of anti-synthetase antibodies among systemic sclerosis patients

13 July 2023
Author(s): Wakar Garra, Yair Levy

Systemic sclerosis (SSc) is a rare, multisystem autoimmune disease. It is divided according to the extent of skin involvement, into limited cutaneous SSc (lcSSc) and diffuse cutaneous SSc (dcSSc) [1...

Clinicopathological characteristics, risk factors and prognostic value of intrarenal vascular lesions in IgA nephropathy

12 July 2023
Author(s): Yiping Ruan, Fuyuan Hong, Miao Lin, Chen Wang, Fayang Lian, Fang Cao, Guokai Yang, Lanting Huang, Qiaoyun Huang

IgA nephropathy (IgAN) is the most prevalent primary glomerulonephritis worldwide, which is characterized by the predominant deposition of IgA in the glomerular mesangium. Although prevalence of... more

Intravenous immunoglobulin therapy in antineutrophil cytoplasmic antibody-associated vasculitis

1 July 2023
Author(s): Fabricio Benavides-Villanueva, Javier Loricera, Vanesa Calvo-Río, Cristina Corrales-Selaya, Santos Castañeda, Ricardo Blanco

According to the International Chapel Hill Consensus Conference 2012 (CHCC2012), anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) is a group of necrotizing vasculitis, with... more

Aortic stiffness plays a role in the discrepancy between mitral valve lesion severity and hemodynamic burden of secondary mitral regurgitation.

29 June 2023
Author(s): Caterina Maffeis, Andrea Rossi, Stefano Bonapace, Lorenzo Cannata, Elvin Tafciu, Mariantonietta Cicoira, Pier Luigi Temporelli

The disproportionate/proportionate nature of secondary mitral regurgitation (sMR) has been recently introduced to explain the different outcomes of patients undergoing percutaneous mitral valve... more

Intravenous continuous home inotropic therapy in advanced heart failure: Insights from an observational retrospective study

29 June 2023
Author(s): Piero Gentile, Gabriella Masciocco, Matteo Palazzini, Andrea Tedeschi, Giacomo Ruzzenenti, Nicolina Conti, Luciana D'Angelo, Grazia Foti, Enrico Perna, Alessandro Verde, Enrico Ammirati, Gianfranco Sinagra, Fabrizio Oliva, Andrea Garascia

Advanced heart failure (AHF) represents 1 to 10% of the overall heart failure (HF) spectrum, with prevalence increasing due to the improvement of survival provided by guideline directed medical... more

Multiple autoimmune syndrome: Clinical, immunological and genotypic characterization

27 June 2023
Author(s): Mariana Fidalgo, Raquel Faria, Cláudia Carvalho, Graziela Carvalheiras, Denisa Mendonça, Fátima Farinha, Berta Martins da Silva, Carlos Vasconcelos

Autoimmune diseases (AIDs) are a heterogeneous group [1–13] with different phenotypes (organ-specific vs. systemic or non-organ specific) [14] and an estimated world prevalence of 3–9.4% [14–17].... more

D-dimer as a diagnostic and prognostic plasma biomarker in patients with a first episode of acute pericarditis

23 June 2023
Author(s): George Lazaros, Panagiotis K. Vlachakis, Panagiotis Theofilis, Foteini E. Dasoula, Massimo Imazio, Emilia Lazarou, Charalambos Vlachopoulos, Costas Tsioufis

Acute pericarditis (AP) is the most common inflammatory heart disorder [1]. AP has recently attracted increasing attention from the medical community and social media during the COVID-19 pandemic... more

Safety and efficacy of non-insulin therapy in non-critically ill hospitalized patients with type 2 diabetes mellitus

22 June 2023
Author(s): Irit Ayalon-Dangur, Tanya Babich, Maayan Huberman Samuel, Leonard Leibovici, Alon Grossman

Clinical guidelines recommend insulin as the mainstay of therapy for hospitalized patients with diabetes mellitus. The aim of the current study is to evaluate safety and efficacy of non-insulin anti-... more

How does current disease activity in rheumatoid arthritis affect the short-term risk of acute coronary syndrome? A clinical register based study from Sweden and Norway

22 June 2023
Author(s): Bénédicte Delcoigne, Sella A. Provan, Eirik K Kristianslund, Johan Askling, Lotta Ljung

Cardiovascular (CV) disease (CVD) co-morbidity and mortality is one of the largest drivers of the excess morbidity and pre-term mortality in patients with rheumatoid arthritis (RA) [1–3]. The... more

Pulmonary rehabilitation and endothelial function in patients with chronic obstructive pulmonary disease: A prospective cohort study

20 June 2023
Author(s): Pasquale Ambrosino, Matteo Nicola Dario Di Minno, Silvestro Ennio D'Anna, Roberto Formisano, Nicola Pappone, Costantino Mancusi, Antonio Molino, Andrea Motta, Mauro Maniscalco

Chronic obstructive pulmonary disease (COPD) is an increasing cause of global morbidity and mortality [1], and cardiovascular (CV) disease accounts for approximately 30% of excess mortality in this... more

Histamine elevation in familial Mediterranean fever: A study from the Juvenile Inflammatory Rheumatism cohort

20 June 2023
Author(s): Nabiha Sbeih, Rim Bourguiba, Nadia Hoyeau-Idrissi, Jean-Marie Launay, Jacques Callebert, Danielle Canioni, Harry Sokol, Véronique Hentgen, Gilles Grateau, Olivier Hermine, Sophie Georgin-Lavialle

Autoinflammatory diseases (AID) are defined according to the International Society of Auto-Inflammatory Diseases as abnormal activation of the innate immunity in the absence of infection or... more

Phenotypic Profiles Among 72 Caucasian and Afro-Caribbean Patients with Antisynthetase Syndrome Involving Anti-PL7 or Anti-PL12 Autoantibodies

15 June 2023
Author(s): Aurore Abel, Estibaliz Lazaro, Mamy Ralazamahaleo, Emma Pierrisnard, Benoit Suzon, Fabrice Bonnet, Patrick Mercié, Julie Macey, Moustapha Agossou, Jean-Francois Viallard, Christophe Deligny, Etienne Rivière

Antisynthetase syndrome (ASyS), a rare and heterogeneous systemic autoimmune disease, is classified as a subtype of idiopathic inflammatory myopathy (IIM). It is associated with at least one of the... more

Recurrence rates and risk factors for recurrence after first episode of acute pancreatitis: A systematic review and meta-analysis

15 June 2023
Author(s): Shuai Li, Lin Gao, Haowen Gong, Longxiang Cao, Jing Zhou, Lu Ke, Yuxiu Liu, Zhihui Tong, Weiqin Li

Acute pancreatitis (AP) has become a prevalent gastrointestinal disorder over the past few decades, with a growing impact on healthcare [1,2]. While most patients with AP experience mild symptoms and... more

Impact of thoracoabdominal imaging on diagnosis and management in patients with suspected infective endocarditis

15 June 2023
Author(s): Matthaios Papadimitriou-Olivgeris, Pierre Monney, David C. Rotzinger, Christel H. Kamani, Guillaume Fahrni, John O. Prior, Nicoleta Ianculescu, Yosra Messaoudi, Piergiorgio Tozzi, Matthias Kirsch, Benoit Guery

A common feature of infective endocarditis (IE) is the risk of organ embolization with approximately 30% of IE patients presenting at least one embolic event (EE), with the most common site of... more

Efficacy and safety assessment of mineralocorticoid receptor antagonists in patients with chronic kidney disease

14 June 2023
Author(s): Kaiyue Ding, Zhuoyu Li, Yingying Lu, Lin Sun

As a global health concern, chronic kidney disease (CKD) is threatening the health of 843.6 million people worldwide and is expected to become the 5th leading cause of death in 2040 [1,2]. CKD is... more

Subclinical coronary atherosclerosis, detected by computer tomography with coronary calcium score, and the occurrence of major cardiovascular events at 5 years of follow-up in a cohort of patients with systemic sclerosis

13 June 2023
Author(s): C Rotondo, S Sciacca, V Rella, G Busto, R Colia, FP Cantatore, A Corrado

Systemic sclerosis (SSc) is a rare disease, with a not well known pathogenesis based on autoimmune dysregulation, charcaterized by clinical triad of vasculopathy, fibrosis of diverse organs, and... more

Early glomerular filtration rates changes and risk of mortality in acute heart failure. The modifying role of admission renal function and decongestion

13 June 2023
Author(s): Miguel Lorenzo, Gonzalo Núñez, Laura Fuertes-Kenneally, Rafael de la Espriella, Sandra Villar, Oscar Miró, Pere Llorens, Enrique Santas, Gema Miñana, Vicent Bodí, Juan Sanchis, Arturo Carratalá, Antoni Bayés-Genís, Julio Núñez

The pathophysiology of changes in estimated glomerular filtration rate (eGFR) in acute heart failure (AHF) is complex and multifactorial. We evaluated the associated mortality risk of early changes... more

Prevalence and significance of antimitochondrial antibodies in autoimmune hepatitis (AIH): Results from a large multicentre study of the International AIH Group

10 June 2023
Author(s): Nikolaos K. Gatselis, Kalliopi Zachou, Aldo J. Montano Loza, Eduardo Luiz Rachid Cançado, Teruko Arinaga-Hino, Paolo Muratori, Cumali Efe, Annarosa Floreani, Pietro Invernizzi, Athushi Takahashi, Akinobu Takaki, Benedetta Terziroli Beretta-Piccoli, Bart van Hoek, Ellina Lytvyak, Laura Vilar Guedes, Tugrul Purnak, Nora Cazzagon, Vasiliki Lygoura, Pinelopi Arvaniti, Eirini I. Rigopoulou, Luigi Muratori, George N. Dalekos, International Autoimmune Hepatitis Group

Autoimmune hepatitis (AIH) is a chronic progressive liver disease leading to end-stage liver disease and/or death, if left untreated [1–3]. Within the spectrum of AIH, some patients exhibiting... more

Ventricular arrhythmias and cardiac arrest in atrial fibrillation patients with pacemakers and implantable cardioverter-defibrillators

6 June 2023
Author(s): Ameenathul M. Fawzy, Arnaud Bisson, Sid A. Bentounes, Alexandre Bodin, Julien Herbert, Gregory Y.H. Lip, Laurent Fauchier

Atrial fibrillation (AF) continues to be a growing epidemic due to its increasing incidence, prevalence, and detrimental consequences. In 2017, the Global Burden of Disease study revealed 37.57... more

Incidence, mortality, and risk factors of acute kidney injury after immune checkpoint inhibitors: Systematic review and meta-analysis of real-world evidence

30 May 2023
Author(s): Wenhui Xie, Shiyu Xiao, Xiaoyuan Li, Jing Huang, Guangtao Li, Zhuoli Zhang

Immune checkpoint inhibitors (ICI) constitute an important breakthrough in anticancer treatments, which has been rapidly and widely prescribed worldwide [1]. There are a variety of ICIs currently... more

Anemia management and transfusion strategy in internal medicine units: Less is more

22 May 2023
Author(s): Deborah Blanca, Giorgio Parrella, Dario Consonni, Stefania Villa, Giuliana Ceriani, Annalisa Cespiati, Giovanni Figini, Gabriele Ghigliazza, Diletta Maira, Giovanna Oberti, Natalia Scaramellini, Giuseppina Luisa Schinco, Francesco Tafuri, Nicola Montano, Maria Domenica Cappellini, Irene Motta

Anemia is a global public health problem affecting subjects of all ages and gender, with significant consequences for human health and an impact on social and economic aspects. The aging of the... more

Genetic and clinical features of familial mediterranean fever (FMF) in a homogeneous cohort of patients from South-Eastern Italy

13 May 2023
Author(s): Agostino Di Ciaula, Matteo Iacoviello, Leonilde Bonfrate, Mohamad Khalil, Harshitha Shanmugam, Giuseppe Lopalco, Rosanna Bagnulo, Antonella Garganese, Florenzo Iannone, Nicoletta Resta, Piero Portincasa, Alessandro Stella

Hereditary recurrent fevers represent a heterogenous group of disorders considered systemic auto inflammatory diseases, caused mostly by monogenic mutations. Familial Mediterranean Fever (FMF), in... more

Review Article

A novel risk factor for malignancy: Albuminuria

22 September 2023
Author(s): Mehmet Kanbay, Sidar Copur, Zeynep Y. Yilmaz, Cem Tanriover, Nuri Baris Hasbal, Alberto Ortiz, Mark A. Perazella

Cancer is a global health concern with 23.6 million new cases globally in 2019, a 26.2 % increase from 2010 [1]. It is the second leading cause of death in adults after cardiovascular diseases,... more

What changed after the 2022 guidelines for pulmonary hypertension?

4 September 2023
Author(s): Mona Lichtblau, Anna Titz, Barbara Bahrampoori, Mark Schmiedeskamp, Silvia Ulrich

With an estimated prevalence of around 1%, pulmonary hypertension (PH) presents a relevant burden worldwide. The revised European Society of Cardiology (ESC) /European Respiratory Society (ERS)... more

A new strategy for anticoagulation: The factor XI inhibitors

4 August 2023
Author(s): Maria Cristina Vedovati, Cecilia Becattini, Giancarlo Agnelli

In the last decade, new oral anticoagulant agents with a direct inhibition of specific clotting factors (DOACs) have been claimed as first-choice therapy for the prevention of cardioembolic events in... more

Cannabidiol's impact on drug-metabolization

3 August 2023
Author(s): Claudia Stöllberger, Josef Finsterer

Cannabis and cannabis-derived substances are worldwide the most frequently consumed psychopharmaceuticals [1]. Over the past decade, attitudes toward the recreational and medicinal use of cannabis... more

Coronary microvascular dysfunction and myocardial infarction with non-obstructive coronary arteries: Where do we stand?

22 July 2023
Author(s): Abdul-Quddus Mohammed, Fuad A. Abdu, Lu Liu, Guoqing Yin, Redhwan M. Mareai, Ayman A. Mohammed, Yawei Xu, Wenliang Che

The term myocardial infarction with non-obstructive coronary arteries (MINOCA) was first coined in 2013 [1] and was globally recognized in an expert position paper as a clinically heterogeneous... more

The role of adherence in patients with chronic diseases

20 July 2023
Author(s): Michel Burnier

In the long-term management of chronic diseases, adherence and persistence to prescribed medications are continuous challenges in order to obtain all the potential benefits of drug therapies.... more

Albumin administration in internal medicine: A journey between effectiveness and futility

7 July 2023
Author(s): Enrico Pompili, Giacomo Zaccherini, Maurizio Baldassarre, Giulia Iannone, Paolo Caraceni

Human albumin is the most abundant circulating protein and accounts for approximately 50–60% of all total plasma proteins in healthy individuals. The molecule is composed of 585 amino acids organised... more

Management of diabetic ketoacidosis

5 July 2023
Author(s): Leonid Barski, Evgeny Golbets, Alan Jotkowitz, Dan Schwarzfuchs

Diabetic ketoacidosis (DKA) is an acute life-threatening emergency in patients with diabetes, characterized by hyperglycemia, metabolic acidosis and ketonemia, it can result in serious morbidity and... more

Axial Spondyloarthritis: Evolving concepts regarding the disease's diagnosis and treatment

5 July 2023
Author(s): Alexandros A. Drosos, Aliki I. Venetsanopoulou, Paraskevi V. Voulgari

Spondyloarthritis (SpA) is a group of inflammatory diseases characterized by the involvement of the axial skeleton (axSpA) and/or the peripheral joints (p-SpA). It affects young adults of both sexes... more

Management of thyroid dysfunction and thyroid nodules in the ageing patient

30 June 2023
Author(s): José Ignacio Martínez-Montoro, Viyey Kishore Doulatram-Gamgaram, Gabriel Olveira, Sergio Valdés, José Carlos Fernández-García

Nowadays, people worldwide are living longer, and every country in the world is experiencing growth in both the size and the proportion of older persons in the population. In line with this, by 2030... more

Ultrasonography as a diagnostic tool for sarcopenia in patients with cirrhosis: Examining the pros and cons

27 June 2023
Author(s): Chiara Becchetti, Annalisa Berzigotti

Skeletal muscle abnormalities, including sarcopenia (pathological muscle mass depletion) and myosteatosis (abnormal fat accumulation in the muscles) are common features in patients with cirrhosis.... more

Future treatments in hypertension: Can we meet the unmet needs of patients?

16 June 2023
Author(s): Mehmet Kanbay, Sidar Copur, Cem Tanriover, Duygu Ucku, Luke Laffin

The prevalence of arterial hypertension, defined as a persistent systolic blood pressure ≥ 130 mm Hg and/or diastolic blood pressure ≥ 80 mm Hg according to American College of Cardiology (ACC) and... more

Potential angiogenic biomarkers in hereditary hemorrhagic telangiectasia and other vascular diseases

22 May 2023
Author(s): B. Villanueva, P. Cerdà, R. Torres-Iglesias, J.L. Rocamora, A. Figueras, F. Viñals, A. Riera-Mestre

Vascular diseases are the main cause of death in developed countries [1]. Despite much progress has been made to improve the management of these diseases, it is difficult to predict those patients at... more

Remote multiparametric monitoring and management of heart failure patients through cardiac implantable electronic devices

17 April 2023
Author(s): Giuseppe Boriani, Jacopo F. Imberti, Niccolò Bonini, Cosimo Carriere, Davide A. Mei, Massimo Zecchin, Francesca Piccinin, Marco Vitolo, Gianfranco Sinagra

Heart failure (HF) is currently an important driver of hospitalizations and re-hospitalizations. It is associated with a high risk of adverse cardiovascular outcomes including death, inducing also an... more


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