Systemic Auto-Inflammatory Diseases (SAID) are diseases with a deregulation of the innate inflammatory response characterized by recurrent fever episodes with systemic inflammation without infectious process [1]. Proinflammatory cytokines play a key role in SAID pathophysiology with Interleukin 1ß (IL-1ß), Interleukin 6 (IL-6), Tumor Necrosis Factor Alpha (TNFα) and Interleukin 17 the most involved cytokines and the target of specific biotherapies [2]. The cytokines involved depend on the type of disease and cause the clinical signs.
