September 2024

32 Articles

No Section

Artificial intelligence in scientific medical writing: Legitimate and deceptive uses and ethical concerns

24 July 2024
Author(s): Davide Ramoni, Cosimo Sgura, Luca Liberale, Fabrizio Montecucco, John P.A. Ioannidis, Federico Carbone

The ghost-writer potential of ChatGPT and related AI tools has been widely discussed in many editorials and essays. Yet, general AI models to-date have failed to fully utilize medical language and... more

Commentary

Commentary on Efficacy and Safety of Low dose ondansetron as a prospective precision medicine to treat alcohol use disorder phenotypes

1 August 2024
Author(s): Robert M. Swift

In this issue of the European Journal of Internal Medicine, Johnson, Addolorato and colleagues [1,2] report the efficacy and safety results of a phase 3, multicenter double-blind placebo-controlled... more

Up and down in gastrointestinal cancer and bleeding with direct oral anticoagulants

25 July 2024
Author(s): Andrés J. Muñoz Martín, Javier Soto Alsar, Laura Ortega Morán

Although direct oral anticoagulants (DOACs) have been established as an effective option for cancer-associated thrombosis (CAT), there are still concerns about their safety in patients with... more

B-cell depletion works in IgG4-related disease. What else?

23 July 2024
Author(s): Emanuel Della-Torre, Lorenzo Dagna

In this volume, Liu et al. perform a rigorous meta-analysis aimed to cover three clinically relevant questions regarding the use of rituximab in patients with IgG4-related disease (IgG4-RD) [1]. Is... more

Internal Medicine Flashcard

Blue-gray pigmentation on the lower legs

22 July 2024
Author(s): Hiroaki Nakagawa, Sugihiro Hamaguchi

An 81-year-old woman presented to our clinic with painless hyperpigmented blue-gray patches on both lower legs (Fig. 1), without associated pruritis. She had been diagnosed with vertebral... more

Acrocyanosis and edema in a male with thrombocytosis, polyneuropathy and monoclonal gammopathy

12 June 2024
Author(s): Íñigo Gredilla Zubiría, Lucía Álvarez Freire, Héctor Meijide Míguez

A 77-year-old male consulted for edema, skin changes, asthenia, anorexia, weight loss and leg corkiness of more than one year of evolution. About two years earlier, primary hypothyroidism was... more

Letter to the Editor

Evaluating cognitive impairment in emergency department: Challenges with screening tools. Authors’ reply

16 July 2024
Author(s): Tanguy Espejo, Leon Chrobok, Christian H. Nickel, Roland Bingisser

We appreciate the thoughtful feedback provided by Khenhrani et al. [1] regarding our article "Prognostic value of cognitive impairment, assessed by the Clock Drawing Test, in emergency department... more

Pioneering the future: CRISPR-Cas9 gene therapy for hereditary hemorrhagic telangiectasia. Author's reply

10 July 2024
Author(s): Pau Cerdà, Cinthia Aguilera, Antoni Riera-Mestre

We read the recent innovative Letter by James and Sehgal, commenting on our article published in the European Journal of Internal Medicine and advocating for the development of a CRISPR-Cas9 gene... more

Autonomic dysfunction in post-acute sequelae of COVID-19

8 July 2024
Author(s): Marie-Claire Seeley, Howard O'Brien, Celine Gallagher, Caelum Schild, Dennis H. Lau

The novel coronavirus disease (COVID-19) pandemic has resulted in over 750 million confirmed cases since its emergence. There has been growing attention towards long-COVID or post-acute sequelae of... more

Pitfalls in the detection of anti-Nucleolar Organizer Region 90 (NOR90) antibodies

22 June 2024
Author(s): Satoshi Kamiya, Yoshinao Muro, Yuta Yamashita, Mariko Ogawa-Momohara, Masashi Akiyama

Dear Editor,

Pioneering the future: CRISPR-Cas9 gene therapy for hereditary hemorrhagic telangiectasia

14 June 2024
Author(s): Michael James, Viren S. Sehgal

We read with great interest the article titled “New genetic drivers in hemorrhagic hereditary telangiectasia’, recently published in the European Journal of Internal Medicine. Cerdà and colleagues... more

The role of age in recognizing cognitive impairment in the emergency department

11 June 2024
Author(s): Ozlem Yilmaz

I read with interest the study by Espejo et al. published in the European Journal of Internal Medicine. In this study, patients presenting to the emergency department with vague symptoms who met the... more

Evaluating cognitive impairment in emergency department: Challenges with screening tools

5 June 2024
Author(s): Raja Ram Khenhrani, Sapna Devi

We read the article by Tanguy Espejo et al. with great interest [1]. The authors have performed admirably in achieving the purpose of the research. The article concludes that Clock Drawing Test (CDT... more

Comparison of factor X inhibitors versus vitamin K antagonists in atrial fibrillation patients on dialysis

19 May 2024
Author(s): Xi Chen, Wengen Zhu, Meiming Lin

Atrial fibrillation (AF) is a common heart rhythm disorder that occurs in patients with end-stage kidney disease (ESKD). Recent studies have shown that the incidence of AF increases in patients... more

Stenting improves cardiovascular clinical outcomes in patients with middle aortic syndrome caused by aortoarteritis: Long-term results

14 May 2024
Author(s): Qian Wang, Hui Dong, Hong-Wu Li, Yu-Bao Zou, Xiong-Jing Jiang

Takayasu arteritis (TA), also known as aortoarteritis, often involves the middle aorta and manifests as middle aortic syndrome (MAS) [1]. Owing to persistent and severe hypertension attributed to... more

Nitrous oxide toxicity in adult patients with sickle cell disease

13 May 2024
Author(s): Katia Stankovic Stojanovic, Aline Santin, Catherine Veyssier-Belot, Jean-Benoit Arlet, François Lionnet

Sickle cell disease (SCD) is an inherited autosomal recessive disorder that confers atypical haemoglobin called haemoglobin S, which can distort red blood cells in sickle-shaped cells and modifies... more

Monkeypox: A risk factor for inflammatory diseases?

3 May 2024
Author(s): Giuseppe Famularo

I read with interest the article by Patauner and colleagues [1]. Even though most cases have a full recovery without significant sequelae, little is known about the mid- and long-term outcome of... more

The new nomenclature SLD and categories provided better classification for elderly Chinese with liver steatosis

3 May 2024
Author(s): Lixia Qiu, Shuang Zhang, Yang Zhang, Calvin Q Pan, Jing Zhang

We were inspired by the recent article by van Erpecum and Dalekos [1], which proposed new horizons in the diagnosis and management of patients with metabolic dysfunction-associated steatotic liver... more

Original Article

Low-dose ondansetron: A candidate prospective precision medicine to treat alcohol use disorder endophenotypes

13 June 2024
Author(s): Bankole Johnson, Hannu Alho, Giovanni Addolorato, Otto Michael Lesch, Jonathan Chick, Lei Liu, Vinzant Schuyler

Alcohol is an addictive substance that contributes to millions of deaths and disabilities worldwide [1]. Excessive alcohol use accounts for 5.1 % of the global disease burden and is the primary risk... more

Efficacy and safety of rituximab induction therapy and effect of rituximab maintenance for IgG4-related disease: a systematic review and meta-analysis

12 June 2024
Author(s): Yixiao Liu, Kehan Jin, Yingyun Yang, Aiming Yang

IgG4-related disease (IgG4-RD) is a rare systemic fibro-inflammatory condition characterized by widespread lesions that exhibit specific histological characteristics [1]. This disease is typically... more

Combining loop with thiazide diuretics in patients discharged home after a heart failure decompensation: Association with 30-day outcomes

18 May 2024
Author(s): Òscar Miró, Julio Núñez, Joan Carles Trullàs, Pedro Lopez-Ayala, Lluís Llauger, Aitor Alquézar-Arbé, Gema Miñana, Anna Mollar, Rafael de la Espriella, Miguel Lorenzo, Javier Jacob, Begoña Espinosa, Vanesa Garcés-Horna, Alfons Aguirre, María José Fortuny, Gemma Martínez-Nadal, Víctor Gil, Christian Mueller, Pere Llorens, ICA-SEMES, INCLIVA, ALCALOTIC research groups

Heart failure (HF) is a highly prevalent cardiovascular condition in people over 65 years old [1]. Mortality associated with HF decompensations (acute HF; AHF) is high, with 30-day and 1-year all-... more

Acute kidney injury predicts mortality in very elderly critically-ill patients

14 May 2024
Author(s): Elisa Alba Schmidt, Silvia De Rosa, Jakob Müller, Paul Hüsing, Rikus Daniels, Pauline Theile, Nils Schweingruber, Stefan Kluge, Tobias B. Huber, Kevin Roedl, Christian Schmidt-Lauber

The age of patients admitted to intensive care units (ICUs) has witnessed a significant increase in the last decades. Recent statistics reveal that ten to fifteen percent of ICU-admitted patients are... more

Effects of a medical admission unit on in-hospital patient flow and clinical outcomes

11 May 2024
Author(s): Ciro Canetta, Silvia Accordino, Elisa La Boria, Gianpiero Arosio, Silvia Cacco, Pietro Formagnana, Michela Masotti, Stella Provini, Sonia Passera, Giovanni Viganò, Fabiola Sozzi

In the last decades the epidemiological transition has brought to several acute complex (elderly, frail and poli-pathological) patients that access to Emergency Departments (ED) and require... more

Development and validation of a novel sleep health score in the sleep heart health study

9 May 2024
Author(s): Muqi Xing, Lingzhi Zhang, Jiahui Li, Zihan Li, Qi Yu, Wenyuan Li

Sleep is closely related to health [1]. Middle-aged and elderly people, especially the elderly, often suffer from sleep disorders, such as sleep apnea and insomnia [2]. These sleep disorders likely... more

Cardiovascular events after exacerbations of chronic obstructive pulmonary disease: Results from the EXAcerbations of COPD and their OutcomeS in CardioVascular diseases study in Italy

9 May 2024
Author(s): Silvia Calabria, Giulia Ronconi, Letizia Dondi, Leonardo Dondi, Irene Dell'Anno, Clementine Nordon, Kirsty Rhodes, Paola Rogliani, Francesco Dentali, Nello Martini, Aldo Pietro Maggioni

Chronic obstructive pulmonary disease (COPD) is a chronic progressive disorder of the lungs with high global morbidity and mortality [1]. The burden and prevalence of COPD are increasing likely due... more

C-reactive protein is more suitable than Serum Amyloid A to monitor crises and attack-free periods in Systemic Auto-Inflammatory Diseases.

8 May 2024
Author(s): Anne-Sophie Parentelli, Anne-Aurélie Lopes, Soraya Fellahi, Léa Savey, Jean-Philippe Bastard, Sophie Georgin-Lavialle

Systemic Auto-Inflammatory Diseases (SAID) are diseases with a deregulation of the innate inflammatory response characterized by recurrent fever episodes with systemic inflammation without infectious... more

Hepatic T1-time, cardiac structure and function and cardiovascular outcomes in patients with dilated cardiomyopathy

7 May 2024
Author(s): Riccardo M. Inciardi, Marco Merlo, Mariagiulia Bellicini, Martina Setti, Antonio De Luca, Nunzia Di Meo, Paolo Rondi, Matteo Pagnesi, Marianna Adamo, Carlo M. Lombardi, Jacopo Giulio Rizzi, Davide Farina, Alessandro Mantovani, Giovanni Targher, Gianfranco Sinagra, Marco Metra, NAFLD-DCM group

Liver damage frequently occurs in patients with cardiovascular (CV) disease and predicts worse clinical outcomes [1,2]. In this context, liver damage may be mainly caused by elevated hepatic venous... more

Direct oral anticoagulant-associated bleeding complications in patients with gastrointestinal cancer and venous thromboembolism

24 April 2024
Author(s): Yuji Nishimoto, Yugo Yamashita, Takeshi Morimoto, Ryuki Chatani, Kazuhisa Kaneda, Nobutaka Ikeda, Yohei Kobayashi, Satoshi Ikeda, Kitae Kim, Moriaki Inoko, Toru Takase, Yukihito Sato, Tetsuya Watanabe, Takahisa Yamada, Masatake Fukunami, Takeshi Kimura, COMMAND VTE Registry-2 Investigators

Venous thromboembolism (VTE), including pulmonary embolism (PE) and deep vein thrombosis (DVT), constitutes the second leading cause of morbidity and mortality in patients with cancer besides the... more

Safety and compliance of long-term low-dose ondansetron in alcohol use disorder treatment.

23 March 2024
Author(s): Giovanni Addolorato, Hannu Alho, Paula Bresciani M․ De Andrade, Otto Michael Lesch, Lei Liu, Bankole Johnson

There are geographical differences regarding alcohol-associated morbidity and mortality, the WHO European Region being the most affected area [1]. Europe leads globally in per capita alcohol... more

Review Article

Ischemia with non-obstructive coronary artery (INOCA): Non-invasive versus invasive techniques for diagnosis and the role of #FullPhysiology

21 July 2024
Author(s): Stefano Benenati, Gianluca Campo, Sara Seitun, Serena Caglioni, Antonio Maria Leone, Italo Porto

Coronary angiography (CA) has historically represented the backbone of the diagnostic algorithm of chronic coronary syndromes. Yet, in more than 50 % of patients complaining of anginal-sounding chest... more

Exploring the nexus: The place of kidney diseases within the cardiovascular-kidney-metabolic syndrome spectrum

18 July 2024
Author(s): Mehmet Kanbay, Mustafa Guldan, Lasin Ozbek, Sidar Copur, Andreea Simona Covic, Adrian Covic

Metabolic syndrome (MS) or Cardiovascular-Kidney-Metabolic (CKM) syndrome, the global epidemic with prevalence increasing from 25.3 % in 1988–1994 to 34.2 % in 2007–2012 in the adult population of... more

East meets West: Bringing the ESH 2023 hypertension guidelines into Asia

2 July 2024
Author(s): Apichard Sukonthasarn, Claudio Borghi, Yu Ho Chan, Federick Cheng, Hyo-In Choi, Radhika Mehta, Binh Le, Ing Haan Lim, Tsing-Hsien Lin, Azhari Rosman, Badai Bhatara Tiksnadi, Athanasios Manolis

Hypertension remains a major problem worldwide, especially across the Asia-Pacific region. According to The NCD Risk Factor Collaboration, which analysed data from 1990 to 2019 on people aged 30–79... more

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