Sepsis is a common and severe disorder characterized by life-threatening organ dysfunction caused by dysregulated host responses to infection and has high morbidity and mortality [1]. Along with treatment of underlying infections, optimization of organ perfusion is the mainstay sepsis management, which includes administration of intravenous fluids and vasopressors [2,3]. These measures are performed to prevent or halt progressive organ damage and to allow recovery. Initial high-volume intravenous fluid administration is the essential first-line maneuver for patients with sepsis considering the success of early goal-directed therapy [2]; however, recent growing concerns that administration of excessive amounts of intravenous fluid may be harmful limit the applicability of intravenous fluid resuscitation [4].
