The small Italian municipality of Vò, located in the Veneto region, northeast of Italy, with a population of nearly 3200 inhabitants, suffered the first COVID-19-related death of the country on February 21, 2020. Immediately, the small town was strictly quarantined for 14 days and all population underwent a two-round testing for SARS-CoV-2 by nasopharyngeal swab, becoming a unique epidemiological experiment for studying COVID-19 infection.