Cardiovascular disease (CVD) accounts for up to 35% of mortality in patients with systemic lupus erythematosus (SLE) [1]. Emerging evidence supports that SLE disease activity is associated with up to two times higher cardiovascular (CV) risk than traditional risk factors [2]. According to an interesting recent study of Salvetti et al. left ventricular function in premenopausal women suffering from SLE was inferior compared to control subjects matched for sex, age, body mass index (BMI), blood pressure and antihypertensive therapy.