Atrial fibrillation (AF) is a highly prevalent condition associated with an increased risk of cardioembolic strokes. Consequently, oral anticoagulation therapy has been established as a cornerstone in the clinical management of patients with AF. However, in patients with an indication for antiplatelet therapy following stent implantation for an acute coronary syndrome (ACS), the optimal antithrombotic strategy in anticoagulated patients remains debated, due to the increased risk of bleeding associated with the use of antiplatelets in dual antithrombotic therapy (DAT) or triple antithrombotic therapy (TAT) regimens.