June 2021

99 Articles

No Section

Low bleeding and thromboembolic risk with continued dabigatran during cardiovascular interventions: the GLORIA-AF study

11 June 2021
Author(s): Sake J. van der Wall, Gregory Y.H. Lip, Christine Teutsch, Oskars Kalejs, Philippe Lyrer, Christian Hall, Sergio J. Dubner, Hans-Christoph Diener, Jonathan L. Halperin, Chang Sheng Ma, Kenneth J. Rothman, Kristina Zint, Dongmei Zhai, Menno V. Huisman, GLORIA-AF Investigators

Non vitamin-K-antagonist oral anticoagulants (NOACs) have emerged as preferred treatment over vitamin K antagonists (VKAs) for the prevention of stroke in patients with nonvalvular atrial... more

An elderly man with a locked jaw

10 June 2021
Author(s): Akitoshi Ueno, Ippei Sakamaki, Yoshihiro Yamamoto

An 86-year-old man with diabetes mellitus presented to our hospital with a 3-day history of difficulty opening his mouth. He reported that he had injured his right index finger while farming 15 days... more

Anakinra or tocilizumab for prevention of COVID-19 death? A big dilemma

5 June 2021
Author(s): Dimitrios Patoulias, Athina Dimosiari, Theodoros Michailidis

We have read with great interest the meta-analysis of observational studies performed by Pasin and colleagues [1] published in the European Journal of Internal Medicine, assessing the efficacy of... more

Painless ulcer on the dorsal aspect of hand

31 May 2021
Author(s): Ting Dai, NingJing Song

A previously healthy 47-year-old man presented a 3-month history of progressive proliferative plaque and ulcer on the dorsal aspect of the right hand. Initially, the patient was bitten by an... more

Predictors of cardiovascular events in patients with primary systemic vasculitis: A 5 years prospective observational study

30 May 2021
Author(s): Anna Borowiec, Ilona Kowalik, Tomasz Chwyczko, Jan Jankowski, Piotr Kandyba, Katarzyna Życińska

: Granulomatosis with polyangiitis (GPA) is one of antineutrophil cytoplasmic autoantibody (ANCA) – associated systemic vasculitis and is characterised by inflammation of blood vessels. Systemic... more

Epidemiology of sarcoidosis in northern Spain, 1999-2019: A population-based study

26 May 2021
Author(s): Raúl Fernández-Ramón, Jorge J. Gaitán-Valdizán, Lara Sánchez-Bilbao, José L. Martín-Varillas, David Martínez-López, Rosalía Demetrio-Pablo, M. Carmen González-Vela, José Cifrián, Santos Castañeda, Javier Llorca, Miguel A. González-Gay, Ricardo Blanco

Sarcoidosis is a multisystem disease of unknown etiology characterized by the formation of non-caseating granulomas [1]. Sarcoidosis primarily affects the lungs and lymphatic system, but any organ... more

Future directions in obesity pharmacotherapy

20 May 2021
Author(s): Nick Finer

Treatment of obesity remains problematic. Compared to other chronic diseases such as hypertension and type 2 diabetes, there are few pharmacological options for treating obesity: thus the treatment... more

Spirometry: A practical lifespan predictor of global health and chronic respiratory and non-respiratory diseases

17 May 2021
Author(s): Alvar Agusti, Leonardo M. Fabbri, Eugenio Baraldi, Bartolome Celli, Massimo Corradi, Rosa Faner, Fernando D. Martinez, Erik Melén, Alberto Papi

We propose that spirometry, a practical and validated marker of respiratory function, is also an overlooked marker of global human health throughout a person’s life span, from infancy to old age,... more

Both lean and fat body mass associate with blood pressure

13 May 2021
Author(s): Päivi E. Korhonen, Tuija Mikkola, Hannu Kautiainen, Johan G. Eriksson

The positive relationship of body mass index (BMI) with blood pressure (BP) has been demonstrated in several large-scale observational studies [1–8]. Importantly, a causal association between BMI and... more

The importance of recognizing cerebral venous thrombosis following anti-COVID-19 vaccination

10 May 2021
Author(s): Alfonso Ciccone, Bruno Zanotti, The working group on cerebral venous thrombosis after COVID-19 vaccination

In March 2021, the reporting of cases of thrombosis post-COVID-19 vaccine AstraZeneca raised safety concerns and determined the temporary suspension of vaccinations in some countries in Europe [1].... more

Non-HACEK gram negative bacilli endocarditis: Analysis of a national prospective cohort.

9 May 2021
Author(s): Jorge Calderón Parra, Daniel De Castro-Campos, Patricia Muñoz García, Maria Olmedo Samperio, Mercedes Marín Arriaza, Aristides De Alarcón, Encarnación Gutierrez-Carretero, Maria Carmen Fariñas Alvarez, Jose María Miró Meda, Miguel Ángel Goneaga Sanchez, Raquel Rodriguez García, Guillermo Ojeda Burgos, Zeltia Valcarce-Gonzalez, Antonio Ramos-Martinez, the Spanish Collaboration on Infectious Endocarditis Group (GAMES) investigators

Infective endocarditis (IE) caused by Gram-negative bacilli (GNB) not included in the HACEK group (Haemophilus, Actinobacillus, Cardiobacterium, Eikenella corrodens, Kingella) is a rare infection... more

Age and comorbidities are crucial predictors of mortality in severe obstructive sleep apnoea syndrome

9 May 2021
Author(s): Domenico Scrutinio, Pietro Guida, Maria Aliani, Giorgio Castellana, Patrizia Guido, Mauro Carone

Obstructive sleep apnoea syndrome (OSAS) is a highly prevalent disorder caused by the collapse of the upper airway during sleep [1]. In a USA nationwide study, 6.6% of 77.8 million individuals aged... more

Very low lipoprotein(a) and increased mortality risk after myocardial infarction

7 May 2021
Author(s): Peter Wohlfahrt, Dominik Jenča, Vojtěch Melenovský, Janka Franeková, Antonín Jabor, Marek Šramko, Vladimír Staněk, Michael Želízko, Rudolf Poledne, Jan Piťha, Věra Adámková, Josef Kautzner

Lipoprotein(a) (Lp[a]) consists of a lipoprotein moiety identical to low density lipoprotein (LDL) cholesterol, as well as a plasminogen-similar glycoprotein apo(a). About 90% of a person's Lp(a)... more

Integrated approach to bronchoalveolar lavage cytology to distinguish interstitial lung diseases

28 April 2021
Author(s): Laura Bergantini, Miriana d'Alessandro, Paolo Cameli, Anna Perrone, Behar Cekorja, Bianca Boncompagni, Maria Antonietta Mazzei, Piersante Sestini, Elena Bargagli

Broncho-alveolar lavage (BAL) is a safe diagnostic procedure, useful for differentiating fibrotic lung disorders and for excluding malignancy and infection [1–5]. Together with chest high resolution... more

Midregional proadrenomedullin safely reduces hospitalization in a low severity cohort with infections in the ED: a randomized controlled multi-centre interventional pilot study

24 April 2021
Author(s): Juan Gonzalez del Castillo, Carlota Clemente-Callejo, Ferran Llopis, Andreea Irimia, Fernando Oltra-Hostalet, Cindy Rechner, Andrej Schwabe, Verónica Fernandez-Rodriguez, Catalina Sánchez-Mora, Jordi Giol-Amich, Belén Prieto-García, Ignasi Bardés-Robles, Maria Dolores Ortega-de Heredia, Eric Jorge García-Lamberechts, Carmen Navarro-Bustos, INFURG-SEMES investigators

Patients with suspected infections presenting to the emergency department (ED) can potentially develop life-threatening conditions [1]. An early assessment of disease severity and the risk of disease... more

A case of suprapubic pain

20 April 2021
Author(s): Ankita Aggarwal, Anubhav Jain

A 71-year-old male with a past medical history of prostate cancer s/p radiation treatment seven years ago. He presented to the emergency department with acute onset pain in the suprapubic region. He... more

Weight-adjusted versus fixed dose heparin thromboprophylaxis in hospitalized obese patients: A systematic review and meta-analysis

19 April 2021
Author(s): Davide Ceccato, Angelo Di Vincenzo, Claudio Pagano, Raffaele Pesavento, Paolo Prandoni, Roberto Vettor

Venous thromboembolism (VTE) is a multi-factorial disease with high morbidity and mortality rates. As it has been reported to occur in about 100–200 cases/100,000 inhabitants per year [1], VTE... more

Safety of treatment with chloroquine and hydroxychloroquine: A ten-year systematic review and meta-analysis

5 April 2021
Author(s): Fernando Luiz Barros Edington, Sandra Rocha Gadellha, Mittermayer Barreto Santiago

Previously known as SN7618, chloroquine has been used since the early 1940s for the treatment of malaria [1]. In 1946 Loeb F. et al., in a statement approved by the board for coordination of malarial... more

The efficacies of entecavir and tenofovir in terms of enhancing prognosis after curative treatment of hepatitis B virus–related hepatocellular carcinoma

30 March 2021
Author(s): Ji Hyun Lee, Beom Kyung Kim, Soo Young Park, Won Young Tak, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Dong Hyun Sinn, Seung Up Kim

Whether entecavir (ETV) or tenofovir disoproxil fumarate (TDF) affords the better prognosis after curative treatment of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) remains unclear... more

Mid-term Prognostic Implication of hospitalized COVID-19 patients with Prior Heart Failure diagnosis

25 February 2021
Author(s): Pau Llàcer, Luis Manzano, Cristina Fernández, Mari Carmen Moreno, Julio Núñez

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that was diagnosed in late 2019 in Wuhan (China)[1]. It has spread... more

The 3Ds – Discussion, diagnosis and direction: Elements for effective obesity care by healthcare professionals

23 January 2021
Author(s): Assim A. Alfadda, Ian D. Caterson, Walmir Coutinho, Ada Cuevas, Dror Dicker, Jason C.G. Halford, Carly A. Hughes, Masato Iwabu, Jae-Heon Kang, Rita Nawar, Ricardo Reynoso, Nicolai Rhee, Georgia Rigas, Javier Salvador, Verónica Vázquez-Velázquez, Paolo Sbraccia

Obesity is a chronic disease associated with multiple health complications [1]. Furthermore, the COVID-19 pandemic has made evident the impact obesity can have on health outcomes, whereby people with... more

Clinical Insights

SARS-CoV-2 vaccine-induced cerebral venous thrombosis

25 May 2021
Author(s): Alfonso Ciccone

Cerebral venous thrombosis (CVT) is a rare cause of stroke and intracranial hypertension syndrome. Compared to arterial stroke, CVT affects younger people, predominantly women, has a different risk... more

Thrombosis with Thrombocytopenia Syndrome associated with viral vector COVID-19 vaccines

25 May 2021
Author(s): Marco Cattaneo

On March 11 2021, the European Medical Agency highlighted two relevant issues, after the decision by the Danish Health Authority to temporarily suspend its vaccination campaign with Vaxzevria (the... more

Commentary

Consumer-led screening for atrial fibrillation: What is the next step?

10 June 2021
Author(s): Georges H. MAIRESSE, Hein Heidbüchel

Atrial fibrillation (AF) is increasingly prevalent in the general population and is associated with significant morbidity and mortality. Opportunistic screening for AF is now a class I indication in... more

Maintenance immunosuppressive therapy in autoimmune hepatitis: To stop or not to stop, that is the question.

20 May 2021
Author(s): Mark F.J. Stolk, Aad P. van den Berg, Karel J. van Erpecum

Autoimmune hepatitis (AIH) is a rare and challenging disease. Its presentation ranges from mildly elevated transaminases to jaundice with decompensated liver disease. Blood tests often reveal... more

Antiviral therapy after curative treatment of hepatocellular carcinoma in patients with chronic hepatitis B infection: Is tenofovir or entecavir preferred?

19 May 2021
Author(s): Karel J. van Erpecum, Milan J. Sonneveld

Hepatitis B remains a major health problem. Globally, approximately 240 million persons are chronically infected (HBsAg positive). Prevalence is decreasing in highly endemic countries due to better... more

What is the role of growth-differentiation factor-15 in biomarker-based prediction of mortality in patients with atrial fibrillation?

11 May 2021
Author(s): Alexander P. Benz, John W. Eikelboom

Physicians often use risk prediction models to help guide diagnosis and inform patient management. Notable examples include the Framingham Risk Score, used to estimate the 10-year risk of coronary... more

Patients with Atrial Fibrillation receiving NOACs: The boundary between appropriate and inappropriate dose

7 May 2021
Author(s): Maria Cristina Vedovati, Michela Giustozzi, Maurizio Paciaroni

Since their introduction in 2010, non-vitamin K oral anticoagulants (NOACs) changed the landscape of stroke prevention in patients with atrial fibrillation (AF). Because of their favorable benefit-... more

The Times They Are A-Changin´: Antithrombotic strategies in patients with acute coronary syndrome undergoing coronary stenting who have concomitant atrial fibrillation

29 April 2021
Author(s): Trygve S. Hall, Dan Atar

Atrial fibrillation (AF) is a highly prevalent condition associated with an increased risk of cardioembolic strokes. Consequently, oral anticoagulation therapy has been established as a cornerstone... more

Editorial

D-dimer testing after anticoagulant discontinuation to predict recurrent venous thromboembolism

26 May 2021
Author(s): Stefano Barco, Frederikus A Klok

The duration of anticoagulant treatment after a first venous thromboembolism (VTE) depends on the risk of a VTE recurrence, which is mostly determined by the presence, type, persistence, and severity... more

Internal Medicine Flashcard

Woman with seizures

10 June 2021
Author(s): Zhen Hu, Wei Wen, Xutao Wang, Xinchao Zhang

A 66-year-old woman with a history of hyperlipidemia presented to the emergency department after a epileptic seizure episode for nearly 1 min. She had a normal temperature, pulse rate was 77 beats/... more

Spontaneous pneumothorax in a patient with skin lesions

3 June 2021
Author(s): Horacio Matías Castro, Martin Pablo Fullana

A 23- year- old man, presented to the emergency department with sudden dyspnea, without another symptom. On examination he had hypoxemia, and abolished breath sounds in the right lung. Skin... more

Recurrent facial palsy and fissured tongue

18 May 2021
Author(s): Mansi Sharma, Vijay K. Sharma

A 28-year old Chinese man presented with right facial paralysis for 8 days. He felt that for first 3-days, his right face was swollen that subsided after starting oral valaciclovir and prednisolone... more

Atypical cause of dysphagia

23 March 2021
Author(s): Dhairya A Lakhani, Aneri B Balar, Abdul R Tarabishy

A 27-years-old male presented with progressively worsening dysphagia for four years. The dysphagia was worse for solids, and for the past three months, the patient had restricted his diet to liquids... more

Letter to the Editor

Etiologies of Polyclonal Hypergammaglobulinemia: A scoping review

11 June 2021
Author(s): Clément BEUVON, Mickaël MARTIN, Chloé BAILLOU, Pascal ROBLOT, Mathieu PUYADE

Dear Editor,

Risk factors of recurrence in patients with cancer-associated venous thromboembolism

7 June 2021
Author(s): Yuji Nishimoto, Yugo Yamashita, Takeshi Morimoto, Yukihito Sato, Takeshi Kimura, COMMAND VTE Registry Investigators

The following other authors from the COMMAND VTE Registry Investigators participated the study: Syunsuke Saga, MDa; Kazushige Kadota, MDb; Toru Takase, MDc; Seiichi Hiramori, MDd; Kitae Kim, MDe;... more

Type of anticoagulation therapy in oldest old, frail people with atrial fibrillation: Prescription modification over time. Authors' Reply

5 June 2021
Author(s): Valeria Calsolaro, Chukwuma Okoye, Sara Rogani, Alessia Maria Calabrese, Fabio Monzani

We would like to thank you for the opportunity to address the issues raised by A.Watanabe in his Letter to the Editor [1] and to clarify some methodological and analytical aspects of our study, while... more

Dynamics of high-sensitivity troponin T and myocardial dysfunction during the first 72 h of septic shock

5 June 2021
Author(s): Cristina Murcia-Gubianas, Juan Carlos Yébenes, Maria Buxó, Josep-Maria Sirvent, Elisabeth Pinart

Cardiomyopathy is frequently associated with septic shock, despite divergences in type and severity of cardiac alterations making difficult the management of these patients. Different studies have... more

Diagnosis of hepatitis C-related liver disease in patients with mild hemophilia

5 June 2021
Author(s): Evelien Krumb, Catherine Lambert, Yves Horsmans, Cedric Hermans

Following the contamination of blood products with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) in the 1970s to 1980s, almost all hemophilia patients who received pasma-derived... more

Use of hydroxychloroquine to control immune response and hypercoagulability in patients with primary antiphospholipid syndrome

4 June 2021
Author(s): Sabrina Saraiva-Mangolin, Camila de Oliveira Vaz, Thays Ruiz, Bruna Moraes Mazetto, Fernanda Andrade Orsi

Dear Editor,

Is troponin testing rather underestimated in clinic practice? Evidence from emergency medical admissions: Authors response

3 June 2021
Author(s): Richard Conway, Bernard Silke

We thank A. Watanabe for his comments on our article, “Is there excessive troponin testing in clinical practice? Evidence from emergency medical admissions” and his suggestions [1,2].

The debated issue of direct oral anticoagulants correct dosing: When even the reviewer is confused

2 June 2021
Author(s): Andrea Rubboli, Dan Atar

While the rejection of a paper submitted to a journal is an inevitable event in the activity of a researcher and must be accepted, sometimes the motivations for such rejection appear questionable or... more

Gender distribution in boards of internal medicine societies

31 May 2021
Author(s): Basil Ryser, Svenja Ravioli, Gregor Lindner

Women account for approximately 75% of the health-sector workforce worldwide [1]. In 2017 43% [2] of physicians in Organization for Economic Development and Co-operation (OECD) countries were women.... more

Is the troponin testing rather underestimated in clinical practice? Evidence from emergency medical admissions

28 May 2021
Author(s): Atsuyuki Watanabe

The novel findings reported by Conway R and colleagues in the current issue of European Journal of Internal Medicine, entitled “Is there excessive troponin testing in clinical practice? Evidence from... more

Type of anticoagulation therapy in oldest old, frail people with atrial fibrillation

21 May 2021
Author(s): Atsuyuki Watanabe

Calsolaro V and colleagues indicated significant benefits of oral anticoagulants (OAC) in oldest-old patients with atrial fibrillation (AF) in the previously published article, entitled “Long-term... more

Direct oral anticoagulants versus enoxaparin in patients with atrial fibrillation and active cancer

10 May 2021
Author(s): Adi Elias, Yael Morgenstern, Eyal Braun, Benjamin Brenner, Inna Tzoran

Atrial fibrillation (AF) is the most prevalent sustained arrhythmia. Benefits of anticoagulation therapy in reducing the risk of ischemic stroke in the majority of patients with AF are well-... more

Validation of the AF-ESUS score to identify patients with embolic stroke of undetermined source and low risk of device-detected atrial fibrillation

2 May 2021
Author(s): Alkisti Kitsiou, Dimitrios Sagris, Wolf-Rüdiger Schäbitz, George Ntaios

During the recent years, the term ESUS (embolic stroke of undetermined source) is used to describe patients with ischemic stroke for whom the source of embolism remains undetected despite recommended... more

Healthcare students: should they be prioritized for COVID-19 vaccination?

29 April 2021
Author(s): Michele Augusto Riva, Maria Emilia Paladino, Michael Belingheri

Not requested.

Convalescent plasma in the management of COVID-19 pneumonia

29 April 2021
Author(s): Ayman Elbadawi, Mina Shnoda, Maryrose Laguio-Vila, Mamas A. Mamas, Islam Y. Elgendy

Few therapeutic agents have been proven to be effective in the management of COVID-19 pneumonia in randomized trials, thus the treatment options for this condition remain limited [1,2]. Convalescent... more

Impact of rate control in hospitalized patients with atrial fibrillation and sepsis

24 April 2021
Author(s): Giulio Francesco Romiti, Marco Proietti

Sepsis is defined as a dysregulated host response to several types of infections [1], still representing a challenging issue in Medicine. Atrial Fibrillation (AF) frequently occurs in patients with... more

Iron deficiency in chronic myocarditis: Assessment and prognostic significance

20 April 2021
Author(s): Giovanni Peretto, Simone Sala, Clara Camaschella

Iron deficiency (ID) and associated anemia (IDA) represent major comorbidities in chronic diseases [1]. However, their prevalence and prognostic significance have never been investigated in... more

Prevalence of proximal deep vein thrombosis in hospitalized COVID-19 patients

8 April 2021
Author(s): Guillaume Reichert, Vincent Bunel, Dora Dreyfuss, Loukbi Saker, Antoine Khalil, Hervé Mal

Severe acute respiratory syndrome coronavirus 2(SARS-COV-2) is a novel virus that has spread worldwide since the end of 2019. Although a proportion of patients remains asymptomatic, the virus may be... more

Intermediate dose thromboprophylaxis in SARS-CoV-2 related venous thrombo embolism

26 March 2021
Author(s): Zahra Haider, Kanendran Rajalingam, Tanveer Khalid, Dilip Oswal, Akshay Dwarakanath

SARS-CoV-2 illness is associated with both pulmonary and extra pulmonary complications with hypoxemia being a marker of severity [1]. Evidence has shown an increase in venous thromboembolism (VTE)... more

Pneumothorax/pneumomediastinum in non-intubated COVID-19 patients: Differences between first and second Italian pandemic wave

18 March 2021
Author(s): Diego Palumbo, Corrado Campochiaro, Alessandro Belletti, Alessandro Marinosci, Lorenzo Dagna, Alberto Zangrillo, Francesco De Cobelli, for the COVID-BioB Study Group

Pneumothorax (PNX) and pneumomediastinum (PMD) have been frequently observed in mechanically ventilated patients with coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome (... more

Pre-admission atrial fibrillation in COVID-19 patients: Prevalence and clinical impact

18 March 2021
Author(s): Vincenzo Russo, Angelo Silverio, Fernando Scudiero, Pierpaolo Di Micco, Marco Di Maio

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly pathogenic human coronavirus recently recognized as the cause of the coronavirus disease 2019 (COVID-19). Italy is one of the... more

Loneliness that destroys and upsets: A lesson from and beyond COVID-19

14 March 2021
Author(s): Christian Bracco, Remo Melchio, Elena Migliore, Chiara Marrale, Luigi Fenoglio

“I've often come up against the bad part about living”. A famous poem by the great poet Eugenio Montale represents well the situation of elderly patients admitted to our hospitals in recent months.

Hellenic Postprandial Lipemia Study (HPLS): Results from the Pre-treatment Postprandial Lipemia

10 March 2021
Author(s): Petros Kalogeropoulos, Helen Bilianou, Vana Kolovou, Athanasios Manolis, Genovefa D. Kolovou

Although fasting triglyceride (TG) levels are routinely measured in clinical practice, studies indicate that postprandial hypertriglyceridemia may be also related to atherosclerosis [1]. Currently,... more

Usefulness of step down units to manage survivors of critical Covid-19 patients

6 March 2021
Author(s): Piero Ceriana, Michele Vitacca, Mara Paneroni, Stefano Belli, Nicolino Ambrosino

The Coronavirus 2 (Covid-19) associated severe acute respiratory failure (ARF) has led to a huge number of admissions to intensive care units (ICU) with high fatality rates and shortage of beds. We... more

Is the “beach position” of value during the “eyeball” assessment of patients?

4 March 2021
Author(s): Alfred Lumala, John Kellett, Jelmer Alsma, Christian H Nickel

The rapid identification at low cost of patients at risk is particularly important in emergency departments in low- and middle-income countries, which may lack experienced emergency healthcare... more

DNA genotyping of the ABO gene showed a significant association of the A-group (A1/A2 variants) with severe COVID-19.

25 February 2021
Author(s): Juan Gómez, Guillermo M Albaiceta, Marta García-Clemente, José M. García-Gala, Eliecer Coto

The coronavirus disease 2019 (COVID-19) is caused by the new beta-coronavirus SARS-CoV-2. The virus has spread worldwide causing a pandemic with millions of infected. The adverse outcome is... more

Effectiveness and safety of high and low dose NOACs in patients with atrial fibrillation

18 February 2021
Author(s): Irene Marzona, Marco Proietti, Pierluca Colacioppo, Andreana Foresta, Marta Baviera

Non-vitamin K antagonist oral anticoagulants (NOACs) were marketed in 2011 as alternatives to Vitamin K Antagonists (VKA) for treatment of thromboembolic risk in atrial fibrillation (AF) patients.... more

Original Article

Prognostic impact of coronary microvascular dysfunction in patients with myocardial infarction with non-obstructive coronary arteries

3 June 2021
Author(s): Fuad A. Abdu, Lu Liu, Abdul-Quddus Mohammed, Guoqing Yin, Bin Xu, Wen Zhang, Siling Xu, Xian Lv, Rui Fan, Cailin Feng, Tingting Shi, Yunlong Huo, Yawei Xu, Wenliang Che

Myocardial infarction with non-obstructive coronary arteries (MINOCA) at coronary angiography (CAG) (stenosis

kinetics of anti-SARS-CoV-2 antibodies over time. Results of 10 month follow up in over 300 seropositive Health Care Workers

25 May 2021
Author(s): Jose F. Varona, Rodrigo Madurga, Francisco Peñalver, Elena Abarca, Cristina Almirall, Marta Cruz, Enrique Ramos, Jose María Castellano-Vazquez

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to an unprecedented health emergency, causing over 125 million... more

Minimal portosystemic encephalopathy: A new nosological entity in patients with hereditary haemorrhagic telangiectasia

18 May 2021
Author(s): Michele Barone, Patrizia Suppressa, Maria Teresa Viggiani, Gennaro Mariano Lenato, Arnaldo Scardapane, Luigi Chiumarulo, Nicola Ambrosini, Alfredo Di Leo, Carlo Sabbà

Hepatic encephalopathy (HE) is a potentially reversible disorder characterized by neuropsychiatric abnormalities and motor disturbances ranging from mild alterations of cognitive and motor functions... more

Incident atrial fibrillation and its risk prediction in patients developing COVID-19: A machine learning based algorithm approach

13 May 2021
Author(s): Gregory Y.H. Lip, Ash Genaidy, George Tran, Patricia Marroquin, Cara Estes

Multi-morbidity is associated with adverse health outcomes and healthcare costs, especially among the elderly [1,2]. Preliminary evidence suggests that multi-morbidity is associated with confirmed... more

A model based on routine liver tests can reliably exclude intrahepatic cholestasis of pregnancy

10 May 2021
Author(s): Inbar Lifshitz, Geffen Kleinstern, Ori Rottenstreich, Shay Porat, Joshua I. Rosenbloom, Doron Kabiri, Moshe Rottenstreich, Yosef Ezra, Oren Shibolet, Rifaat Safadi, Amihai Rottenstreich

Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disease in pregnancy [1,2]. It usually manifests in the late second or third trimesters of pregnancy and is characterized by... more

Refining age stratum of the C2HEST score for predicting incident atrial fibrillation in a hospital-based Chinese population

10 May 2021
Author(s): Yan-Guang Li, Jin Bai, Gongbu Zhou, Juan Li, Yi Wei, Lijie Sun, Lingyun Zu, Shuwang Liu

The incidence of atrial fibrillation (AF) increases with age and accumulating comorbidities, conferring significant risks of ischemic stroke [1], heart failure (HF) [2], and mortality [3,4].... more

Clinical significance of anti-Ro52 (TRIM21) antibodies in adult patients with connective tissue diseases

7 May 2021
Author(s): Paul Decker, Thomas Moulinet, Benjamin Lopez, Sylvain Dubucquoi, Bernard Bonnotte, Daniela Lakomy, Sabine Revuz, Amandine Luc, Marcelo De Carvalho Bittencourt, Eric Hachulla, Roland Jaussaud

Connective tissue diseases (CTD) – rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Sjögren syndrome (SS), systemic sclerosis (SSc), idiopathic inflammatory myopathies (IIM), mixed... more

Inhaled antibiotics for treatment of adults with non-cystic fibrosis bronchiectasis: A systematic review and meta-analysis

1 May 2021
Author(s): Sofia Tejada, Laura Campogiani, Candela Solé-Lleonart, Aroa Gómez, Miguel Gallego, Monserrat Vendrell, Joan B. Soriano, Jordi Rello

Non-cystic fibrosis bronchiectasis (NCFB) is a chronic, progressive respiratory disease characterized by permanent and abnormal dilation of the bronchial walls, mucociliary dysfunction, mucus... more

Prevalence, determinants and practical implications of inappropriate hospitalizations in older subjects: A prospective observational study

1 May 2021
Author(s): Gianluca Isaia, Enrico Brunetti, Roberto Presta, Bianca Salone, Giulia Carignano, Matteo Sappa, Gianfranco Fonte, Silvio Raspo, Giuseppe Lauria, Franco Riccardini, Enrico Lupia, Mario Bo

Over the last decades, along with the aging of the population, an increase in the demand for medical services has been observed in developed countries. Older people are more prone to illnesses, often... more

Diagnostic accuracy of D-Dimer testing for recurrent venous thromboembolism: A systematic review with meta-analysis.

29 April 2021
Author(s): Matteo Nicola Dario Di Minno, Ilenia Calcaterra, Antimo Papa, Roberta Lupoli, Alessandro Di Minno, Mauro Maniscalco, Pasquale Ambrosino

With an annual incidence of 1-2 per 1,000 individuals, venous thromboembolism (VTE) is the third leading vascular diagnosis after heart attack and stroke [1,2]. VTE encompasses two interrelated... more

Clinical outcomes of biliary drainage of malignant biliary obstruction due to colorectal cancer metastases: A systematic review

27 April 2021
Author(s): Janine B Kastelijn, Maria ATC van der Loos, Paco MJ Welsing, Elisabeth Dhondt, Miriam Koopman, Leon MG Moons, Frank P. Vleggaar

Malignant biliary obstruction is an ominous complication of metastatic colorectal cancer (mCRC) and is associated with a poor prognosis.[1–3] It has been reported to occur in 10% of patients with... more

Serum uric acid and outcomes in patients with chronic heart failure through the whole spectrum of ejection fraction phenotypes: Analysis of the ESC-EORP Heart Failure Long-Term (HF LT) Registry

23 April 2021
Author(s): Giuseppe Ambrosio, Marisa G. Crespo Leiro, Lars H. Lund, Stefano Coiro, Andrea Cardona, Gerasimos Filippatos, Roberto Ferrari, Massimo F. Piepoli, Andrew J.S. Coats, Stefan D. Anker, Cécile Laroche, Luis Almenar-Bonet, Pentti Poder, David Bierge Valero, Anna Frisinghelli, Aldo P. Maggioni

Heart failure (HF) is a heterogeneous clinical syndrome, associated with a spectrum of metabolic disorders. Serum uric acid (sUA), the end-product of purine degradation, has shown prognostic value in... more

Joint effect of heart failure and coronary artery disease on the risk of death during hospitalization for COVID-19

19 April 2021
Author(s): Fabio Angeli, Jacopo Marazzato, Paolo Verdecchia, Antonella Balestrino, Claudio Bruschi, Piero Ceriana, Luca Chiovato, Laura Adelaide Dalla Vecchia, Roberto De Ponti, Francesco Fanfulla, Maria Teresa La Rovere, Francesca Perego, Simonetta Scalvini, Antonio Spanevello, Egidio Traversi, Dina Visca, Michele Vitacca, Tiziana Bachetti

Since the initial coronavirus (SARS-CoV-2) outbreak in the province of Wuhan, China, more than 50 million people have been infected so far, causing unnerving impact on routine patient care and... more

Adrenomedullin as a potential biomarker involved in patients with hereditary hemorrhagic telangiectasia

19 April 2021
Author(s): A. Iriarte, L. Ochoa-Callejero, J. García-Sanmartín, P. Cerdà, P. Garrido, J. Narro-Íñiguez, JM. Mora-Luján, A. Jucglà, MA Sánchez-Corral, F. Cruellas, E. Gamundi, J. Ribas, J. Castellote, F. Viñals, A. Martínez, A. Riera-Mestre

Hereditary hemorrhagic telangiectasia (HHT) or Rendu–Osler–Weber syndrome (ORPHA774) is a rare autosomal dominant vascular disease characterized by telangiectases and larger vascular malformations (... more

Autologous fecal microbiota transplantation can retain the metabolic achievements of dietary interventions

18 April 2021
Author(s): Ehud Rinott, Ilan Youngster, Anat Yaskolka Meir, Gal Tsaban, Alon Kaplan, Hila Zelicha, Elad Rubin, Omry Koren, Iris Shai

We recently reported that autologous fecal microbiota transplantation (aFMT), derived from the time of maximal weight-loss and administrated in the regain-phase, might preserve weight loss and... more

Efficacy and safety of steroid-sparing treatments in giant cell arteritis according to the glucocorticoids tapering regimen: A systematic review and meta-analysis

17 April 2021
Author(s): Anne-Laure Gérard, Noémie Simon-Tillaux, Youri Yordanov, Patrice Cacoub, Florence Tubach, David Saadoun, Agnès Dechartres

Giant cell arteritis (GCA) is the most common systemic vasculitis in Western countries, with an annual incidence of 10 to 20 per 100,000 adults older than 50 years and increasing with age [1]. Its... more

Adiponectin involved in portal flow hepatic extraction of 13C-methacetin in obesity and non-alcoholic fatty liver

15 April 2021
Author(s): Agostino Di Ciaula, Federico Carbone, Harshitha Shanmugham, Emilio Molina-Molina, Leonilde Bonfrate, Stefano Ministrini, Fabrizio Montecucco, Piero Portincasa

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease with a worldwide prevalence of about 30% [1]. NAFLD frequently occurs in overweight and obese individuals [... more

Drug withdrawal in patients with autoimmune hepatitis in long-term histological remission: A prospective observational study

14 April 2021
Author(s): Floris F. van den Brand, Romée J.A.L.M. Snijders, Ynto S. de Boer, Bart J. Verwer, Carin M.J. van Nieuwkerk, Elisabeth Bloemena, Sjoerd D. Kuiken, Joost P.H. Drenth, Gerd Bouma

Recommendations for drug withdrawal in patients with autoimmune hepatitis (AIH) in longstanding remission are conflicting and rely on retrospective data. We prospectively investigated the predictive... more

Post-discharge antithrombotic management and clinical outcomes of patients with new-onset or pre-existing atrial fibrillation and acute coronary syndromes undergoing coronary stenting: Follow-up data of the MATADOR-PCI study

7 April 2021
Author(s): Leonardo De Luca, Andrea Di Lenarda, Andrea Rubboli, Leonardo Bolognese, Lucio Gonzini, Federico Fortuni, Alessandro Navazio, Fabrizio Poletti, Antonietta Ledda, Stefano Urbinati, Domenico Gabrielli, Michele Massimo Gulizia, MATADOR-PCI Investigators

. Patients with concomitant atrial fibrillation (AF) and acute coronary syndromes (ACS) do not seem to receive proper antithrombotic therapies and present high rates of adverse clinical events.

Sex-specific differences in the presentation, clinical course, and quality of life of patients with acute venous thromboembolism according to baseline risk factors. Insights from the PREFER in VTE

30 March 2021
Author(s): Michela Giustozzi, Luca Valerio, Giancarlo Agnelli, Cecilia Becattini, Eva-Maria Fronk, Frederikus A. Klok, Stavros V. Konstantinides, Maria Cristina Vedovati, Alexander T. Cohen, Stefano Barco

The presentation and prognosis of venous thromboembolism (VTE) are known to be characterized by considerable sex differences. While men and women have a similar overall risk of developing a first... more

Lessons from pathophysiology: Use of individualized combination treatments with immune interventional agents to tackle severe respiratory failure in patients with COVID-19

26 March 2021
Author(s): George N. Dalekos, Aggelos Stefos, Sarah Georgiadou, Vasiliki Lygoura, Anastasia Michail, George Ntaios, Anna Samakidou, George Giannoulis, Stella Gabeta, Marianna Vlychou, Efthymia Petinaki, Konstantinos Leventogiannis, Evangelos J. Giamarellos-Bourboulis, Nikolaos K. Gatselis

Aims Infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may lead to the development of severe respiratory failure. In hospitalized-patients, prompt interruption of the virus-... more

Growth differentiation factor-15 predicts major adverse cardiac events and all-cause mortality in patients with atrial fibrillation

8 March 2021
Author(s): Stephan Nopp, Oliver Königsbrügge, Daniel Kraemmer, Ingrid Pabinger, Cihan Ay

Atrial fibrillation (AF), the most common cardiac arrhythmia, is associated with high morbidity and mortality, largely attributable to an increased risk of stroke and systemic embolism.... more

Myocardial infarction during giant cell arteritis: A cohort study

17 February 2021
Author(s): Hélène Greigert, Marianne Zeller, Alain Putot, Eric Steinmetz, Béatrice Terriat, Maud Maza, Nicolas Falvo, Géraldine Muller, Louis Arnould, Catherine Creuzot-Garcher, André Ramon, Laurent Martin, Georges Tarris, Tibor Ponnelle, Sylvain Audia, Bernard Bonnotte, Yves Cottin, Maxime Samson

Giant cell arteritis (GCA) is the most frequent vasculitis in adults over 50 years. It is a granulomatous large-vessel vasculitis mainly involving the aorta and cranial arteries [1–3]. Clinical signs... more

Patient motivation to lose weight: Importance of healthcare professional support, goals and self-efficacy

5 February 2021
Author(s): Dror Dicker, Assim A. Alfadda, Walmir Coutinho, Ada Cuevas, Jason C.G. Halford, Carly A. Hughes, Masato Iwabu, Jae-Heon Kang, Rita Nawar, Ricardo Reynoso, Nicolai Rhee, Georgia Rigas, Javier Salvador, Paolo Sbraccia, Verónica Vázquez-Velázquez, Ian D. Caterson

Obesity is a global health concern [1]. Multiple complications are associated with overweight and obesity including diabetes, heart disease, musculoskeletal disorders and some cancers, and people... more

Research paper

SARS-CoV-2 antibody kinetics eight months from COVID-19 onset: Persistence of spike antibodies but loss of neutralizing antibodies in 24% of convalescent plasma donors

17 May 2021
Author(s): Evangelos Terpos, Dimitris Stellas, Margherita Rosati, Theodoros N. Sergentanis, Xintao Hu, Marianna Politou, Vassiliki Pappa, Ioannis Ntanasis-Stathopoulos, Sevasti Karaliota, Jenifer Bear, Duncan Donohue, Maria Pagoni, Elisavet Grouzi, Eleni Korompoki, George N. Pavlakis, Barbara K. Felber, Meletios A. Dimopoulos

The duration of antibody responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an area of extensive research in light of the new approvals of vaccines against SARS-CoV-2... more

Review Article

Risk of stroke in CYP2C19 LoF polymorphism carrier coronary artery disease patients undergoing clopidogrel therapy: An ethnicity-based updated meta-analysis

3 June 2021
Author(s): Sarah Jafrin, Nura Ershad Naznin, Md. Sharif Reza, Md. Abdul Aziz, Mohammad Safiqul Islam

Stroke is one of the major causes of morbidity and disability in the elderly peoples, with a global prevalence of 104.2 million people in 2017. According to global statistics, Central and East Asia,... more

Combining New Classes of Drugs for HFrEF: from Trials to Clinical Practice

2 June 2021
Author(s): Gianfranco Sinagra, Linda Pagura, Davide Stolfo, Enrico Fabris, Gianluigi Savarese, Claudio Rapezzi, Roberto Ferrari, Marco Merlo

Standard of care for heart failure (HF) with reduced ejection fraction (HFrEF) combines inhibition of the renin-angiotensin-aldosterone system (RAAS) and blockade of the sympathetic system. Evidences... more

“Is medical cannabis safe for my patients?” A practical review of cannabis safety considerations

31 May 2021
Author(s): Caroline A. MacCallum, Lindsay A. Lo, Michael Boivin

The use of cannabis for medical purposes is increasing worldwide [5,32]. With the changing public and political opinion, more countries are implementing medical cannabis legalization. Although... more

Physical activity in management of persons with obesity

21 May 2021
Author(s): Jean-Michel Oppert, Alice Bellicha, Cécile Ciangura

Physical inactivity is an important determinant of weight gain and development of obesity. Among multiple determinants of body fat gain over time, special consideration has indeed been given to... more

Obesity and sleep disturbances: The “chicken or the egg” question

14 May 2021
Author(s): Gabriel Dias Rodrigues, Elisa M. Fiorelli, Ludovico Furlan, Nicola Montano, Eleonora Tobaldini

Since 1980 obesity has seen a rapid increase in global prevalence, that has almost doubled in many countries and nowadays affects more than 12% of the general population [1]. Interestingly, the rapid... more

The use of β-blockers in patients with heart failure and comorbidities: Doubts, certainties and unsolved issues

30 April 2021
Author(s): Stefania Paolillo, Simona Dell'Aversana, Immacolata Esposito, Alessandra Poccia, Pasquale Perrone Filardi

β-blockers represent a mainstay in the pharmacological approach to patients affected by heart failure with reduced ejection fraction (HFrEF). However, underuse of this class of drugs is still... more

Rabies in Europe: An epidemiological and clinical update

29 April 2021
Author(s): Niccolò Riccardi, Andrea Giacomelli, Roberta Maria Antonello, Federico Gobbi, Andrea Angheben

Rabies is a vaccine preventable zoonosis with a significant mortality burden worldwide, causing about 60,000 deaths each year [1]. Nevertheless, rabies is still a neglected disease [2]. Rabies is... more

SARS-CoV-2 vaccines: Lights and shadows

29 April 2021
Author(s): Fabio Angeli, Antonio Spanevello, Gianpaolo Reboldi, Dina Visca, Paolo Verdecchia

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread across the world and killed more than 2.9 million individuals globally, with 137 million cases being confirmed by... more

Obesity as an adipose tissue dysfunction disease and a risk factor for infections – Covid-19 as a case study

2 April 2021
Author(s): MF Landecho, M Marin-Oto, B Recalde-Zamacona, I Bilbao, Gema Frühbeck

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV2) disease (COVID-19) is a novel threat that hampers life expectancy especially in obese individuals. Though this association is clinically... more

Sweet taste and obesity

13 February 2021
Author(s): Gabriela Ribeiro, Albino J. Oliveira-Maia

Obesity is associated with significant morbidity and mortality, and currently represents a global health challenge[1]. While it is associated with complex pathophysiology, increased availability of... more

Mechanisms of weight regain.

16 January 2021
Author(s): Luca Busetto, Silvia Bettini, Janine Makaronidis, Carl A. Roberts, Jason C.G. Halford, Rachel L. Batterham

Obesity is a chronic progressive disease with a high tendency to recidivism. Weight regain is frequent after any attempts of voluntary weight loss [1]. Weight regain is frequently attributed to the... more

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