Use of personal protective equipment (PPE) aims to prevent SARS CoV-2 transmission in the healthcare setting. However, PPE limits human connection and non-verbal communication by masking individuals’ facial gestures and body language. Contact isolation potentially presents considerable psychological consequences for patients and healthcare providers (HCPs) [1]. During the 2015 Ebola outbreak, HCPs utilized PPE portraits to humanize care and bridge communication gaps [2]. With increasing PPE portrait use during the coronavirus disease 2019 (COVID-19) pandemic, we sought to summarize and critically evaluate the available evidence of PPE portraits on clinical care.