Solid organ transplantation (SOT) has become an increasingly common procedure in the management of end-stage organ disease. While sex is a biologically determined characteristic that affects the function and structure of organs, its impact on SOT outcomes is not well understood. Tejada et al. [1] reviewed the existing literature and female patients account for 1/3 of the SOT recipient's cohort [1]. The authors did a careful meta-analysis on the question whether biological sex influences outcome (especially survival) after SOT.