Heart failure (HF) is currently an important driver of hospitalizations and re-hospitalizations. It is associated with a high risk of adverse cardiovascular outcomes including death, inducing also an important use of human and financial resources [1]. In recent years, systems to monitor cardiac function and patient parameters have been developed with the aim to detect subclinical pathophysiological changes preceding worsening HF. Early detection of subclinical changes is meant to trigger specific decisions and actions, thus possibly preventing subsequent HF hospitalizations [2–6].