Atherosclerosis is a chronic and progressive process promoted by several environmental and genetic factors [1,2]; among these, low-density lipoprotein cholesterol (LDL-C) has been recognized to have a causal role in the pathogenesis of atherosclerotic cardiovascular disease (ASCVD) [3]. Familial hypercholesterolemia (FH) is a genetic condition characterized by lifelong exposure to high levels of LDL-C, which favors atherosclerosis progression and increases ASCVD risk especially in early life [4].
