The introduction of non-vitamin K antagonist oral anticoagulants (NOAC) in antithrombotic therapy is one of the major recent milestones in the general pharmacopeia [1]. Despite several papers about real-life use and impact of NOACs have been published, showing overall consistency with data reported in the RCTs, data coming from Italian daily clinical practice are still scarce [2,3]. To improve the knowledge about the real impact of NOACs-related bleeding events admission to emergency department (ED), we performed a retrospective chart search collecting all available clinical and laboratory variables from medical records of patients taking NOACs admitted into the largest tertiary hospital in Southern Italy for any kind of bleeding event.
