Obstructive sleep apnea (OSA) is a highly prevalent [1] and heterogeneous sleep disorder [2], characterized by frequent collapses of the upper airway that induce intermittent hypoxia and sleep fragmentation. These episodes activate various biological mechanisms that can lead to the onset or worsening of cardio-metabolic diseases [3]. OSA is significantly increasing the risk of early mortality compared to the general population [4,5]. Research on mortality in these patients has highlighted the complexity and heterogeneity of associated factors involved, showing that it is not sufficient to consider only some polysomnographic indices to summarize the complete picture [6].
