February 2025
36 ArticlesCommentary
Risk factors for community-acquired acute kidney injury: Challenges and perspectives
Acute kidney injury (AKI), even in its milder forms, significantly contributes to increased morbidity and mortality among both hospitalized and non-hospitalized individuals. However, AKI is now... more
Hypertension and heart failure: A dangerous relationship with clinical implications
Heart failure (HF) is currently classified into three categories, according to left ventricular (LV) ejection fraction (LVEF): HF with reduced ejection fraction (HFrEF; LVEF <40%), HF with mid-... more
Exploring predictors of pulmonary embolism in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease
In this issue of the European Journal of Internal Medicine, Mismetti et al. published an original article titled "Predictors of pulmonary embolism in chronic obstructive pulmonary diseases patients... more
Hypertension management: The lesson from the SARS-CoV-2 pandemic
Hypertension is a major risk factor for cardiovascular diseases and a major cause of premature death worldwide [1]. Its regular monitoring is crucial for reducing cardiovascular risk, since it is the... more
The new ESC 2024 guidelines on the management of peripheral arterial and aortic diseases: Lights and shadows
The new guidelines on the management of peripheral arterial and aortic diseases have been released at the European Society of Cardiology (ESC) Annual Congress 2024 and published simultaneously [1].... more
Hyperhomocysteinaemia and MASLD: Causal relationship or spurious correlation?
Metabolic dysfunction-associated liver disease (MASLD) is the most common chronic liver disease worldwide and a leading cause of liver-related morbidity and mortality, affecting one-third-of the... more
Editorial
A new era in optimization of anti-infective therapy: Current challenges and priorities
Managing infectious diseases is an ever increasing challenge keeping pace with rising antimicrobial resistance, emerging pathogens and changing treatment paradigms. In a changing world, COVID-19,... more
Internal Medicine Flashcard
Coronary artery pulsatile ectasia and multiple occlusion in an adolescent male
An adolescent male was referred to our hospital due to dyspnea persisting for over a month. He has no previous medical illness and is not taking any medications. There was no history of smoking or... more
Hemiatrophy of the face and limb
A 64-year-old man presented to the Department of Neurology with recurrent head discomfort for over eight years and right-side facial and limb atrophy for five years. The head discomfort usually... more
A woman with unconsciousness and tachycardia after drug overdose.
A 44-year-old female was brought to our emergency department due to impaired consciousness. On arrival, her Glasgow Coma Scale score was 6. Her blood pressure was 102/60 mmHg, her heart rate was 132... more
Letter to the Editor
Vaccination trends and recent therapeutics to encounter resurgence of monkeypox
The World Health Organization (WHO) declared a public health emergency of international concern (PHEIC) on the resurgence of monkeypox after the 2022–2023 epidemic, a zoonotic ailment with primary... more
External factors affecting weight loss during intermittent fasting. Author's reply
Dear Editor,
Comparative safety and efficacy analysis of GLP-1 receptor agonists and SGLT-2 inhibitors among frail individuals with type 2 diabetes in the era of continuous population ageing
Dear Editor,
Clinical significance of the anti-Nucleolar Organizer Region 90 antibodies (NOR90) in systemic sclerosis
We read with great interest the article by Dima et al. on the clinical significance of the anti-Nucleolar Organizer Region antibodies (NOR90) in systemic sclerosis (SSc) [1]. The authors conducted a... more
The prediction of alterations in plasma sodium levels in acutely ill patients should be more comprehensive. Author's reply
We thank Jaguszewski et al. [1] for their interest in our article [2] and their thoughtful comments.
External factors affecting weight loss during intermittent fasting
we read with great interest a recently published study by Mohamad Khalil, Hala Abdallah, et al. regarding distinct biophysiological effects of Ramadan fasting and traditional intermittent fasting on... more
A bibliometric analysis of awake prone positioning for non-intubated patients
The global coronavirus disease 2019 (COVID-19) pandemic led to severe medical, economic, and social challenges, including a critical shortage of mechanical ventilators and intensive care unit beds [1... more
Enhancing immunization strategies in heart failure: A call to action
Heart failure (HF) is a severe cardiovascular pathology with escalating prevalence and notable morbidity and mortality on a global scale. Addressing this condition presents an imperative, in order to... more
DNA methylation levels of the ACE2 promoter are not associated with symptoms-severity and related-disability in previously hospitalized COVID-19 survivors
The presence of long-lasting symptoms after suffering an acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has recently extensive attention in the last years. One of the first meta-... more
The prediction of alterations in plasma sodium levels in acutely ill patients should be more comprehensive
We read with great interest the article by Simon et al. entitled "Prediction of plasma sodium changes in the acutely ill patients: the potential role of tissue sodium content"[1]. The study focuses... more
Immune heterogeneity associated with disease severity and activity in eosinophilic granulomatosis with polyangiitis patients
Dear Editor,
Precision medicine in COPD: A possible contribution of vitamin D?
we read the interesting review by Gilda Varricchi and Remo Poto on the most innovative and recent therapeutic approaches for COPD [1].
Original Article
Adherence to the 2019 ESC/EAS guidelines for dyslipidaemia management in a large rheumatoid arthritis cohort: Data from the CORDIS Study Group of the Italian Society of Rheumatology
The evidence that several variables, including inflammation, autoimmunity and traditional cardiovascular (CV) risk factors, closely interact to enhance atherosclerotic risk burden in rheumatoid... more
Association of non-cardiac comorbidities and sex with long-term Re-hospitalization for heart failure
Heart failure (HF) is a complex clinical syndrome, the course of which is usually complicated by concomitant comorbidities [1–6]. However, in spite of this long-held notion, the impact of non-cardiac... more
Hyperhomocysteinemia is linked to MASLD
Arterial Hypertension
Systolic blood pressure, a predictor of mortality and life expectancy following heart failure hospitalization, 2010–2023
Each year, over 1 million Americans are admitted to hospitals with heart failure (HF) as the primary discharge diagnosis [1]. Hospitalization for acute decompensated HF (ADHF) represents a critical... more
Association between trajectory of systolic blood pressure and outcomes in heart failure patients with preserved ejection fraction (HFpEF)
Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous disease which accounts for 50 % of all heart failure [1–3]. Currently, treatment for HFpEF not only focuses on improving... more
TLR4 and TNF-α single nucleotide polymorphisms in patients with brucellosis: Association with infection complications
Brucellosis is a zoonotic infectious disease caused by Brucella spp, an intracellular facultative anaerobe Gram negative bacteria transmitted to humans by domestic (cattle, goats, sheep, swine, dogs... more
Prediction of left ventricular thrombus after myocardial infarction: a cardiac magnetic resonance-based prospective registry
Left ventricular thrombus (LVTh) is a rare but serious complication following ST-segment elevation myocardial infarction (STEMI) [1–4]. During the prethrombolytic era, LVTh was detected in up to 60%... more
Prospective study of risk factors for community-acquired acute kidney injury
Acute kidney injury (AKI) is a common condition, both in hospital and outpatient settings, and is associated with increased mortality, prolonged hospital stay, progressive chronic kidney disease (CKD... more
A large language model-based clinical decision support system for syncope recognition in the emergency department: A framework for clinical workflow integration
Syncope is a common presenting symptom in the emergency department (ED), [1,2] the management of which poses inherent challenges, starting from recognition. Crucial information is collected during... more
The impact of the COVID-19 Pandemic on hypertension phenotypes (ESH ABPM COVID-19 study)
The COVID-19 pandemic had a significant impact on various aspects of public health. The imposed restrictions forced people to spend more time at home, which may have resulted in a decline in physical... more
Predictors of pulmonary embolism in chronic obstructive pulmonary diseases patients admitted for worsening respiratory symptoms: An individual participant data meta-analyses
Chronic obstructive pulmonary disease (COPD) is a widespread condition with significant morbidity and mortality [1,2]. It is one of the leading causes of death and is already expected to experience a... more
Review Article
Translating evidence into practice: Managing electrolyte imbalances and iron deficiency in heart failure
Heart failure (HF) is defined as a clinical syndrome with symptoms and/or signs caused by a structural and/or functional cardiac abnormality, corroborated by elevated natriuretic peptides and/or... more
Triglyceride glucose (TyG) index: A promising biomarker for diagnosis and treatment of different diseases
Insulin resistance (IR) is a metabolic condition in which insulin levels are elevated due to insensitivity to insulin and associated with elevated triglyceride levels. Hypertriglyceridemia leads to... more
Chronic obstructive pulmonary disease's eosinophilic phenotype: Clinical characteristics, biomarkers and biotherapy
COPD is a complex, heterogeneous, and chronic inflammatory disorder of the airways characterized by persistent and poorly reversible airflow limitation, along with significant respiratory symptoms... more